Patents by Inventor John Mathison

John Mathison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for inhibiting CD14 mediated cell activation
    Publication number: 20060073145
    Abstract: This invention provides hybridoma cell lines producing monoclonal antibodies which inhibit CD14 mediated cell activation. Monoclonal antibodies produced by these cell lines also are provided. The antibodies are useful for the detection of the presence of cell surface and soluble CD14 in a sample. Chimeric and CDR grafted antibodies generated from the above monoclonal antibodies are further provided. Pharmaceutical compositions containing the above biological compositions are provided. These are useful to treat and prevent disorders with CD14 mediated cell activation, such as sepsis.
    Type: Application
    Filed: September 3, 2002
    Publication date: April 6, 2006
    Inventors: Didier Leturcq, Ann Moriarty, Richard Ulevitch, Peter Tobias, John Mathison