Patents by Inventor John Matiskella

John Matiskella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES
    Publication number: 20080119480
    Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
    Type: Application
    Filed: January 17, 2008
    Publication date: May 22, 2008
    Inventors: Tao Wang, Zhongxing Zhang, Nicholas Meanwell, John Kadow, Zhiwei Yin, Qiufen Xue, Alicia Regueiro-Ren, John Matiskella, Yasutsugu Ueda
  • HIV integrase inhibitors
    Publication number: 20070111984
    Abstract: The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: October 31, 2006
    Publication date: May 17, 2007
    Inventors: B. Naidu, Yasutsugu Ueda, John Matiskella, Michael Walker, Jacques Banville, Francis Beaulieu, Carl Ouellet, Serge Plamondon
  • HIV integrase inhibitors
    Publication number: 20070111985
    Abstract: The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: November 10, 2006
    Publication date: May 17, 2007
    Inventors: B. Naidu, Margaret Sorenson, Yasutsugu Ueda, John Matiskella, Michael Walker
  • Bicyclic heterocycles as HIV integrase inhibitors
    Publication number: 20060276466
    Abstract: The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: August 16, 2006
    Publication date: December 7, 2006
    Inventors: B. Naidu, Jacques Banville, Francis Beaulieu, Timothy Connolly, Mark Krystal, John Matiskella, Carl Ouellet, Serge Plamondon, Roger Remillard, Margaret Sorenson, Yasutsugu Ueda, Michael Walker
  • HIV integrase inhibitors
    Patent number: 7135467
    Abstract: Compounds useful for treating HIV are disclosed having the general formula wherein R1, R2, and B are as defined in the specification. Compositions containing the compounds and methods for using the compounds to inhibit HIV are also disclosed.
    Type: Grant
    Filed: January 12, 2004
    Date of Patent: November 14, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael A. Walker, Hatice Belgin Gulgeze, Narasimhulu B. Naidu, Margaret E. Sorenson, Yasutsugu Ueda, John Matiskella
  • Bicyclic heterocycles as HIV integrase inhibitors
    Publication number: 20060199956
    Abstract: The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: November 29, 2005
    Publication date: September 7, 2006
    Inventors: B. Naidu, Jacques Banville, Francis Beaulieu, Timothy Connolly, Mark Krystal, John Matiskella, Carl Ouellet, Serge Plamondon, Roger Remillard, Margaret Sorenson, Yasutsugu Ueda, Michael Walker
  • Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
    Publication number: 20060100432
    Abstract: The instant invention provides crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such crystalline materials; pharmaceutical compositions comprising such crystalline materials; and methods of treating HIV or AIDS with such crystalline materials or such pharmaceutical compositions.
    Type: Application
    Filed: November 4, 2005
    Publication date: May 11, 2006
    Inventors: John Matiskella, Chenkou Wei, Qi Gao, Chong-Hui Gu, Shan-Ming Kuang
  • Bicyclic heterocycles as HIV integrase inhibitors
    Publication number: 20050267131
    Abstract: The invention encompasses a series cyclic bicyclic heterocyclic compounds of Formula I which are inhibitors of HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: May 26, 2005
    Publication date: December 1, 2005
    Inventors: B. Naidu, Jacques Banville, John Matiskella, Serge Plamondon, Yasutsugu Ueda
  • Bicyclic heterocycles as HIV integrase inhibitors
    Publication number: 20050267105
    Abstract: The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: May 11, 2005
    Publication date: December 1, 2005
    Inventors: B. Naidu, Jacques Banville, Francis Beaulieu, Timothy Connolly, Mark Krystal, John Matiskella, Carl Ouellet, Serge Plamondon, Roger Remillard, Margaret Sorenson, Yasutsugu Ueda, Michael Walker
  • Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
    Publication number: 20050090522
    Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
    Type: Application
    Filed: October 20, 2004
    Publication date: April 28, 2005
    Inventors: Tao Wang, Zhongxing Zhang, Nicholas Meanwell, John Kadow, Zhiwei Yin, Qiufen Xue, Alicia Regueiro-Ren, John Matiskella, Yasutsugu Ueda
  • HIV integrase inhibitors
    Publication number: 20040204498
    Abstract: Compounds useful for treating HIV are disclosed having the general formula 1
    Type: Application
    Filed: January 12, 2004
    Publication date: October 14, 2004
    Inventors: Michael A. Walker, Hatice Belgin Gulgeze, Narasimhulu B. Naidu, Margaret E. Sorenson, Yasutsugu Ueda, John Matiskella