Abstract: The invention relates to substituted heterocycles of the general formula I, and the use of the compounds of the present invention for the treatment and/or prevention of hyperproliferative diseases and disorders in mammals, especially humans, and pharmaceutical compositions containing such compound.

Abstract: An ultrasound imaging system, a method, and computer-implemented media. The system includes: context determination circuitry (CDC) to generate context signals based on one or more ultrasound imaging session contexts of an ultrasound imaging session; a memory storing a context information engine (CIE); circuitry coupled to the memory and adapted to execute the CIE to determine one or more context parameters of the ultrasound imaging session based on the context signals from the CDC; and processing circuitry to: access the one or more context parameters before or during the ultrasound imaging session; and determine one or more ultrasound imaging settings of the ultrasound imaging session based on the one or more context parameters; and cause the one or more settings to be implemented for the ultrasound imaging session.

Abstract: A device for providing respiratory gases comprises a blower configured to receive a first gas from a first gas flow path and generate a flow of a first gas provided through a first gases outlet of the blower; a second gas flow path configured to receive a flow of a second gas and provide the flow of the second gas through a second gases outlet; and a mixing chamber configured to receive a flow of the first gas from the first gases outlet and a flow of the second gas from the second gases outlet. The received gases are configured to mix in the mixing chamber to form a mixed gas. The received gases are configured to travel in a mixing flow direction in the mixing chamber towards a mixed gases inlet, wherein mixed gas exits the mixing chamber via the mixed gases inlet providing flow to a mixed gas flow path.

Abstract: Provided herein are compounds of Formula (I), a compound selected from any of the compounds in Table 1, Table 2, Table 3, or a pharmaceutically acceptable salt or deuterated form thereof, wherein R1, R2, R3 and R4 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of formula (I), or a compound selected from any of the compounds in Table 1, Table 2, Table 3, or pharmaceutically acceptable salt or deuterated form thereof, and methods of using a compound of formula (I) or pharmaceutically acceptable salt or deuterated form thereof, e.g., in treating 5-HT2A receptor associated diseases or disorders.

Abstract: Provided herein are compounds of Formula (I), Formula (II), Formula (III), a compound selected from any of the compounds in Table 1, Table 2, Table 3, Table 4 or a pharmaceutically acceptable salt or deuterated form thereof, wherein R1, R2, R3, R4, RD, RG, p and q are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of formula (I), or a compound selected from any of the compounds in Table 1, Table 2, Table 3, Table 4 or pharmaceutically acceptable salt or deuterated form thereof, and methods of using a compound of formula (I), Formula (II), Formula (III), or pharmaceutically acceptable salt or deuterated form thereof, e.g., in treating 5-HT2A receptor associated diseases or disorders.

Abstract: Embodiments herein are generally directed to spinal implants, systems, apparatuses, and components thereof that can be used in spinal fusion and/or stabilization procedures, as well as methods of installation. The spinal implants may include an intervertebral spacer and a plate member.

Abstract: The present disclosure provides, inter alia, a pharmaceutically acceptable oral dosage form comprising an ionically chargeable hydrogel and a protective coating for delivery of an ionically chargeable active agent to an intestinal site. Also provided are methods for treatment using the pharmaceutically acceptable oral dosage form disclosed herein.

Abstract: The present invention relates to processes for producing fermentation products from starch-containing material, wherein a thermostable alpha-amylase and optionally a thermostable protease are present and/or added during liquefaction. The invention also relates to a composition suitable for use in a process of the invention.

Abstract: Disclosed herein are an exemplary apparatus, system, and methods (e.g., Tactical Passive RFID transponder gloves with Morphological Actuation) comprising a glove made predominately of a resistive fabric that varies resistance per degree of deformation; comprising near field communication RFID tag readers, and a controller coupled to the glove to evaluate the varied resistance. A method of classifying RFID tags is also disclosed.

Abstract: In implementations of systems for generating review likelihoods for sets of code, a computing device implements a review system to compile input data based on code data describing information associated with a set of new code to be incorporated into a set of existing code and reviewer data describing information associated with a potential reviewer of sets of code. The review system processes the input data using a machine learning model trained on training data to generate review likelihoods for potential reviewers of sets of code to be selected to review sets of new code. A review likelihood for the potential reviewer of sets of code to be selected to review the set of new code is generated using the machine learning model based on processing the input data. The review system generates an indication of the review likelihood for display in a user interface.

Abstract: A load control system may be configured using a graphical user interface (GUI) software. The GUI software may be implemented to collect control devices and add the control devices to the load control system for configuration. Programming data may be automatically determined for the added control devices based on the type of control device, the location of the control device, and/or the load type controlled by the control device. The programming data may include control settings for a scene, a schedule, or an automated control feature. The programming data may be displayed for being viewed and/or adjusted by a user. The programming data may be transmitted to the control devices and/or a system controller for being implemented in performing load control.

Abstract: A secondary battery for cycling between a charged and a discharged state, wherein a 2D map of the median vertical position of the first opposing vertical end surface of the electrode active material in the X-Z plane, along the length LE of the electrode active material layer, traces a first vertical end surface plot, EVP1, a 2D map of the median vertical position of the first opposing vertical end surface of the counter-electrode active material layer in the X-Z plane, along the length LC of the counter-electrode active material layer, traces a first vertical end surface plot, CEVP1, wherein for at least 60% of the length Lc of the first counter-electrode active material layer (i) the absolute value of a separation distance, SZ1, between the plots EVP1 and CEVP1 measured in the vertical direction is 1000 ?m?|SZ1|?5 ?m.

Abstract: In one aspect, a method of confirming identity of an entity is disclosed. The method comprises receiving a plurality of items for delivery to an address, obtaining, from the items, information regarding an entity associated with the items and the address, and delivering the items to the address. The method may also comprise identifying an expected identity of the entity, receiving a request to confirm an identity of the entity using third-party identity verification via a user interface, and determining, based on the information regarding the entity, a confidence score for the expected identity. The method may further comprise determining whether the confidence score is greater than or equal to the threshold value and generating a response to the request. The method may additionally comprises displaying the response via the user interface.

Abstract: Secondary batteries and methods of manufacture thereof are provided. A secondary battery can comprise an offset between electrode and counter-electrode layers in a unit cell. Secondary batteries can be prepared by removing a population of negative electrode subunits from a negative electrode sheet, the negative electrode sheet comprising a negative electrode sheet edge margin and at least one negative electrode sheet weakened region that is internal to the negative electrode sheet edge margin, removing a population of separator layer subunits from a separator sheet, and removing a population of positive electrode subunits from a positive electrode sheet, the positive electrode sheet comprising a positive electrode edge margin and at least one positive electrode sheet weakened region that is internal to the positive electrode sheet edge margin, and stacking members of the negative electrode subunit population, the separator layer subunit population and the positive electrode subunit population.

Abstract: Systems and methods for data warehouse management for medical information is provided. The system receives a set of medical record documents. These documents include evidence for one or more findings which are identified using natural language processing of evidence. The data set is probabilistically transformed into a structured data set (often as a table). This structured data set includes embedded links that reference the source document where the evidence is located. If the finding is supported by multiple articles of evidence, the link will direct the user to the source document with the highest confidence ranking. Evidence in the source document is highlighted and may include associated annotations. Evidence, findings and annotations may be updated by the user.

Abstract: A method of using microbial methods to form mineral based material elements via the precipitation of calcium-carbonate into an element composed primarily of aggregate is provided. Pressure is applied across at least part of the element being produced in order to drive a bulk flow of a liquid containing nutrients at least partly through the element to the bacteria. Structures in the element may be used to enhance transfer of reagents and nutrients to the microbes within the material.