Patents by Inventor John Matthew Fevig

John Matthew Fevig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxygen or sulfur containing heteroaromatics as factor Xa inhibitors
    Patent number: 6962935
    Abstract: The present application describes oxygen and sulfur containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is O or S and D may be C(?NH)NH2, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: November 8, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: James Russell Pruitt, John Matthew Fevig, Mimi Lifen Quan, Donald Joseph Phillip Pinto
  • Oxygen or sulfur containing heteroaromatics as factor Xa inhibitors
    Publication number: 20040073029
    Abstract: The present application describes oxygen and sulfur containing heteroaromatics and derivatives thereof of formula I: 1
    Type: Application
    Filed: April 9, 2003
    Publication date: April 15, 2004
    Inventors: James Russell Pruitt, John Matthew Fevig, Mimi Lifen Quan, Donald Joseph Phillip Pinto
  • Thiazoles as factor Xa inhibitors
    Patent number: 6569874
    Abstract: The present application describes oxygen and sulfur containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is O or S and D may be C(═NH)NH2, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: May 27, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: James Russell Pruitt, John Matthew Fevig, Mimi Lifen Quan, Donald Joseph Phillip Pinto
  • Nitrogen containing heteroaromatics as factor Xa inhibitors
    Patent number: 6548512
    Abstract: The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(═NH)NH2, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: April 15, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Donald Joseph Phillip Pinto, James Russell Pruitt, Joseph Cacciola, John Matthew Fevig, Qi Han, Michael James Orwat, Mimi Lifen Quan, Karen Anita Rossi
  • Phenyl-isoxazoles as factor XA Inhibitors
    Patent number: 6187797
    Abstract: The present application describes oxygen and sulfur containing heteroaromatics and derivatives thereof of formula or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is O or S and D may be C(═NH)NH2, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: February 13, 2001
    Assignee: Dupont Pharmaceuticals Company
    Inventors: James Russell Pruitt, John Matthew Fevig, Mimi Lifen Quan, Donald Joseph Phillip Pinto
  • Electrophilic peptide analogs as inhibitors of trypsin-like enzymes
    Patent number: 6060462
    Abstract: This invention relates to electrophilic dipeptide analogs conjugated to an N,N-disubstituted .alpha.-amino acid as inhibitors of trypsin-like serine protease enzymes.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: May 9, 2000
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Robert Anthony Galemmo, Jr., Matthew Mark Abelman, Eugene Cruz Amparo, John Matthew Fevig, Robert Madara Knabb, William Henry Miller, Gregory James Pacofsky, Patricia Carol Weber, Joseph Cacciola
  • Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
    Patent number: 6057342
    Abstract: The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(.dbd.NH)NH.sub.2 and the other H, and J.sup.1 and J.sup.2 may be O or CH.sub.2, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: May 2, 2000
    Assignee: Dupont Pharmaceutical Co.
    Inventors: John Matthew Fevig, Donald Joseph Phillip Pinto, Mimi Lifen Quan, Petrus Fredericus Wilhelmus Stouten
  • Nitrogen containing heteroaromatics as factor Xa inhibitors
    Patent number: 6020357
    Abstract: The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(.dbd.NH)NH.sub.2, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: February 1, 2000
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Donald Joseph Phillip Pinto, James Russell Pruitt, Joseph Cacciola, John Matthew Fevig, Qi Han, Michael James Orwat, Mimi Lifen Quan, Karen Anita Rossi
  • .alpha.-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors
    Patent number: 5942544
    Abstract: The present application describes m-amidino phenyl analogs of formula I: ##STR1## wherein D can be amidino and E can be phenyl, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: February 19, 1997
    Date of Patent: August 24, 1999
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Thomas Peter Maduskuie, Jr., Joseph Cacciola, John Matthew Fevig, Mimi Lifen Quan, Petrus Fredericus Wilhelmus Stouten
  • Piperidine containing aminobornic acids
    Patent number: 5731439
    Abstract: The present invention relates generally to .alpha.-aminoboronic acids and corresponding peptide analogs in which the .alpha.-carbon is substituted with an optionally functionalized piperidine containing alkyl group. These compounds are useful as inhibitors of trypsin-like serine protease enzymes.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: March 24, 1998
    Assignee: The DuPont Merck Pharmaceutical Company
    Inventors: David John Carini, Joseph Cacciola, Celia Dominguez, John Matthew Fevig
  • Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes
    Patent number: 5658885
    Abstract: This invention relates to Novel .alpha.-aminoacid and .alpha.
    Type: Grant
    Filed: October 25, 1994
    Date of Patent: August 19, 1997
    Assignee: The DuPont Merck Pharmaceutical Company
    Inventors: Sheng-Lian O. Lee, David John Carini, John Matthew Fevig, Charles Adrian Kettner, Padmaja Mantri, Zixia Feng
  • Imidazole containing aminoboronic acids
    Patent number: 5639739
    Abstract: The present invention relates generally to .alpha.-aminoboronic acids and corresponding peptide analogs of the formula (I): ##STR1## in which the .alpha.-carbon is substituted with an optionally functionalized imidazole containing alkyl group. These compounds are useful as inhibitors of trypsin-like serine protease enzymes, especially thrombin, Factor X and Factor VII.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: June 17, 1997
    Assignee: The DuPont Merck Pharmaceutical Company
    Inventors: Celia Dominguez, Joseph Cacciola, John Matthew Fevig