Abstract: This invention provides for certain bridged and fused compounds of the formula G-L-A I or a pharmaceutically acceptable salt, ester of solvate thereof wherein: A is: (I) and the other variables are defined herein; the inventive compounds are agonists of the G-protein coupled receptor 40 (GPR40, also known as free fatty acid receptor FFAR). This invention further relates to pharmaceutical compositions containing these compounds, and the use of these compounds to regulate insulin levels in a mammal. The compounds may be used, for example in the prevention and treatment of Type 2 diabetes mellitus and in the prevention and treatment of conditions related to Type 2 diabetes mellitus, such as insulin resistance, obesity and lipid disorders.

Abstract: A method and apparatus for separating a first fluid from a fluid mixture. In one embodiment water containing methane is passed through an agitation chamber with a plate at the chamber's proximal and distal ends. Both plates have orifices permitting the mixed fluid to pass into and out of the agitation chamber. In one embodiment, the mixed fluid rotates about its axis of flow through the agitation chamber. In one embodiment, the mixed fluid passes through a separation chamber having a plurality of baffles that promote separation of the methane from the methane/water mixture. In one embodiment, the separated methane is removed from the water in a collection chamber that facilitates gravity separation of the mixed fluids. In one embodiment, liquid hydrocarbon is removed from water.

Abstract: A transgenic non-human animal genetically modified to have a dysfunctional 26S-proteasome in some or all cells, which may exhibit phenotypic and/or neuropathological symptoms similar to those exhibited by individuals with a neurogenerative disorder.

Abstract: A relief valve including a generally cylindrical housing with first and second openings. The first opening is defined by a flange having an internal shoulder located adjacent the first opening. A pin is provided in the housing and has a first end and a second end opposite of the first end. A spring is positioned about the pin. A seal is located at the second end of the pin and adjacent the second opening of the housing. A clip is located at the first end of the pin and engages the internal shoulder of the flange to compress the spring between the clip and the seal.

Abstract: One embodiment relates to a valve including a tubular housing with first and second openings and an internal shoulder adjacent to the first opening. The valve further includes a pin having a first end and a second end opposite of the first end, a spring positioned about the pin, a seal located at the second end of the pin and adjacent the second end of the tubular housing, and a clip located at the first end of the pin. The clip engages with the internal shoulder of the tubular housing to compress the spring between the clip and the seal.

Abstract: Described herein are elastomeric materials, and in particular porous biodegradable elastomeric materials which optionally may have microintegrated cells. Also described herein are bioprosthetic devices that can be manufactured using the biodegradable elastomeric materials, non-limiting examples of such devices including pulmonary valves, vocal chords, and blood vessels.

Abstract: Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.

Abstract: The present invention encompasses peptides that selectively activate the VPAC2 receptor and are useful in the treatment of diabetes.

Abstract: An apparatus for deactivating medical instruments and devices having a circulation system for circulating fluids through the apparatus and a chemical delivery assembly for generating a deactivation fluid to circulate through the circulation system. The chemical delivery assembly is comprised of a chemistry housing that has a first receptacle and a second receptacle formed therein. A first fluid inlet communicates with the first receptacle. A second fluid inlet communicates with the second receptacle. A first fluid outlet is disposed near an upper portion of the first receptacle to establish a predetermined fluid level in the first receptacle when fluid is introduced into the first receptacle. A second fluid outlet is disposed near an upper portion of the second receptacle to establish a predetermined fluid level in the second receptacle when fluid is introduced into the second receptacle. A lid is attached to the chemistry housing. The lid is movable between a first position and a second position.

Abstract: A method of generating a microbial deactivation fluid to circulate through an apparatus that has a decontamination chamber for holding medical instruments and devices, comprising the steps of: (a) providing a first compartment and a second compartment in the circulation system; (b) providing a chemical reagent in the first compartment and a builder composition in the second compartment; (c) causing a fluid to flow through the second compartment to mix with the builder composition to create an alkaline fluid; (d) when the alkaline fluid has reached a predetermined pH level, causing the alkaline fluid to flow through the first compartment to mix with the chemical reagent to dissolve the chemical reagent to generate a microbial deactivation fluid; and (e) continuing steps (c) and (d) to continue the generation of the microbial deactivation fluid.

Abstract: An apparatus for deactivating medical instruments and devices. The apparatus has a housing structure and a drawer disposed in the housing structure. The drawer has a recess formed therein and a planar surface formed about the periphery of the recess. The recess is dimensioned to receive medical instruments and devices to be microbially deactivated. A circulation system is provided within the housing structure to circulate a microbial deactivation fluid through the recess. A drawer-sealing assembly is located in the housing structure. The drawer-sealing assembly is operable to engage the drawer assembly and fluidly seal the recess to create a decontamination chamber.

Abstract: An apparatus for deactivating medical instruments and devices comprised of a deactivation chamber movable between a loading position and a deactivation position. A circulation system is provided to circulate a deactivating fluid through the deactivation chamber. The circulation system is connectable to the deactivation chamber when the deactivation chamber is in the deactivation position.

Abstract: The present invention relates to peptide agonists of the MC4 receptor, and as such are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and male and/or female sexual dysfunction.

Abstract: The present invention provides methods of treating metabolic disorders, including, for example, obesity, diabetes mellitus, cachexia, sarcopenia, and cardiovascular disorders, methods of inducing weight loss and increasing muscle mass in a patient, by administration of MC3R agonist peptides. Furthermore, the present invention provides the use of an MC3R agonist peptide for the manufacture of a medicament for the treatment of metabolic disorders, including, for example, obesity, diabetes mellitus, cachexia, sarcopenia, and cardiovascular disorders, inducing weight loss and increasing muscle mass in a patient.

Abstract: A method and arrangement to control fuel material debris originating from a fuel assembly for a dry storage system wherein the method includes providing a damaged boiling water reactor nuclear fuel assembly, providing a bottom end cap configured to fit on a bottom of a boiling water reactor nuclear fuel assembly, inserting the bottom end cap into the damaged boiling water reactor nuclear fuel assembly such that the bottom end cap prevents debris from inside the damaged nuclear fuel assembly from leaving the bottom of the fuel assembly, providing a top end cap configured to fit on a top of the boiling water reactor nuclear fuel assembly, and inserting the top end cap into the top of the damaged boiling water reactor nuclear fuel assembly such that the top end cap prevents debris from inside the damaged nuclear fuel assembly from leaving the top of the fuel assembly.

Abstract: The compound 1-(indole-6-carbonyl-D-phenylglycinyl)-4-(1-methylpiperidin-4-yl)piperazine and physiologically-tolerable salts thereof are factor Xa inhibitors useful for the treatment of thrombotic disorders.

Abstract: Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.

Abstract: A system for monitoring conditions relating to the status of items such as perishable food products stored in enclosed spaces has a number of sensors mounted in the spaces. Tables maintained by the system hold a description of the spaces to be monitored and the location and identity of the sensors within each space. The values detected by each sensor are periodically recorded and tested against benchmark values established for the stored items adjacent to the sensor. Values outside of the benchmark values create an alarm condition, and a set of alarm messages are displayed on a display unit. The alarm messages include suggested corrective actions. The user has the opportunity to signal to the system the corrective actions taken, and the system stores a record of these corrective actions in association with the corrective actions and the alarm condition.

Abstract: Compounds of formula (I) 1