Abstract: A device and method for detecting the presence of a target analyte in a fluid sample are provided. The device can include an inclined capillary tube for transporting a sample fluid containing a sample and functionalized magnetic beads. The functionalized magnetic beads capture the target analyte from the sample fluid. A well is coupled with the inclined capillary tube for containing a developer solution and for receiving the sample fluid. In at least one embodiment a magnet is movably attached to the inclined capillary tube for attracting the magnetic beads of the sample fluid and moving the magnetic beads into the well. A calorimeter is disposed adjacent to the well for receiving heat output from a reaction caused by an enzyme reaction associated with the captured target analyte in the developer solution thereby allowing detection and quantification of the target analyte.

Abstract: One aspect of the present disclosure relates to a calorimeter for detecting the presence of a target analyte in a fluid sample. The calorimeter can include a support structure, a hermetically-sealed, thermally decoupled central reaction zone associated with the support structure, at least one droplet transport region, and detection electronics. The at least one droplet transport region can be associated with the support structure and configured to merge a reagent droplet with a sample droplet including the fluid sample to form a reaction droplet in the central reaction zone. The detection electronics can be in electrical and/or thermal communication with the central reaction zone and associated with the support structure. The calorimeter can be configured to detect a heat of reaction produced by a reaction event between the target analyte and a capture reagent upon formation of the reaction droplet.

Abstract: Methods of treating a subterranean formation penetrated by a well bore, by providing a first acidic treatment fluid comprising fibers to fracture the formation and providing a non-acidic treatment fluid comprising multiple particle size acid precursors having a first average particle size between about 3 mm and 2 cm and a second amount of acid precursors having a second average size between about 1.6 and 20 times smaller than the first average particle size or a second amount of flakes having a second average size up to 10 times smaller than the first average particle size.

Abstract: A device and method for detecting the presence of a target analyte in a fluid sample are provided. The device can include an inclined capillary tube for transporting a sample fluid containing a sample and functionalized magnetic beads. The functionalized magnetic beads capture the target analyte from the sample fluid. A well is coupled with the inclined capillary tube for containing a developer solution and for receiving the sample fluid. In at least one embodiment a magnet is movably attached to the inclined capillary tube for attracting the magnetic beads of the sample fluid and moving the magnetic beads into the well. A calorimeter is disposed adjacent to the well for receiving heat output from a reaction caused by an enzyme reaction associated with the captured target analyte in the developer solution thereby allowing detection and quantification of the target analyte.

Abstract: The present invention relates to vesicular formulations for the treatment of rosacea. It also relates to a method of treating rosacea comprising administering a vesicular formulation according to the invention.

Abstract: Methods of treating a subterranean formation penetrated by a well bore, by providing a first acidic treatment fluid comprising fibers to fracture the formation and providing a non-acidic treatment fluid comprising multiple particle size acid precursors having a first average particle size between about 3 mm and 2 cm and a second amount of acid precursors having a second average size between about 1.6 and 20 times smaller than the first average particle size or a second amount of flakes having a second average size up to 10 times smaller than the first average particle size.

Abstract: Disclosed is a runway alerting method and system for an aircraft performing a landing maneuver. During the landing maneuver, a minimum stopping position and a maximum stopping position for the aircraft along the runway is determined using aircraft energy state, deceleration and braking information. The minimum stopping position is based upon the aircraft performing a maximum flare maneuver prior to touchdown on the runway and the maximum stopping position is based upon the aircraft performing a minimum flare maneuver prior to touchdown on the runway. The minimum and maximum stopping positions are presented to the aircraft pilot on a display to assist the pilot in safely landing the aircraft.

Abstract: Disclosed is a runway alerting method and system for an aircraft during a take-off maneuver. The method includes determining stopping positions for the aircraft along the runway using aircraft energy state, deceleration and braking information and displaying the stopping positions on a display.

Abstract: One aspect of the present disclosure relates to a calorimeter for detecting the presence of a target analyte in a fluid sample. The calorimeter can include a support structure, a hermetically-sealed, thermally decoupled central reaction zone associated with the support structure, at least one droplet transport region, and detection electronics. The at least one droplet transport region can be associated with the support structure and configured to merge a reagent droplet with a sample droplet including the fluid sample to form a reaction droplet in the central reaction zone. The detection electronics can be in electrical and/or thermal communication with the central reaction zone and associated with the support structure. The calorimeter can be configured to detect a heat of reaction produced by a reaction event between the target analyte and a capture reagent upon formation of the reaction droplet.

Abstract: The present invention relates to compositions containing vesicular formulations, kits, methods of preparation thereof or uses thereof. The present invention provides improved combinations of formulations, for topical use.

Abstract: The present invention relates to vesicular formulations for use in the topical administration of a biologically active agent, methods of administering a biologically active agent, a combined preparation comprising a vesicular formulation and a kit comprising a vesicular formulation.

Abstract: One aspect of the present disclosure relates to a calorimeter for detecting the presence of a target analyte in a fluid sample. The calorimeter can include a substrate, a hermetically-sealed, thermally decoupled central reaction zone associated with the substrate, at least one droplet transport region, and detection electronics. The at least one droplet transport region can be associated with the substrate and configured to merge a reagent droplet with a sample droplet including the fluid sample to form a reaction droplet in the central reaction zone. The detection electronics can be in electrical and/or thermal communication with the central reaction zone and associated with the substrate. The calorimeter can be configured to detect a heat of reaction produced by a reaction event between the target analyte and a capture reagent upon formation of the reaction droplet.

Abstract: The present invention relates to vesicular formulations for the treatment of rosacea. It also relates to a method of treating rosacea comprising administering a vesicular formulation according to the invention.

Abstract: Disclosed is a runway alerting method and system for an aircraft during a take-off maneuver. The method includes determining stopping positions for the aircraft along the runway using aircraft energy state, deceleration and braking information and displaying the stopping positions on a display.

Abstract: Disclosed is a runway alerting method and system for a landing an aircraft. The method includes determining stopping positions for the aircraft along the runway using aircraft energy state, deceleration and braking information and displaying the stopping positions on a display. A system is provided that includes a first apparatus that is configured to determine an aircraft speed relative to the ground, a second apparatus that is configured to determine the aircraft's position, and a third apparatus that can provide information about the runway of intended landing. A flight system coupled to the first and second apparatus is configured to determine a minimum and corporate stopping position for the aircraft using the aircraft speed and the position relative to the runway. The minimum and corporation stopping positions are presented to the aircraft pilot on a display to as assist the pilot in safely landing the aircraft.

Abstract: The present invention relates to a graphical display for cueing helicopter main rotor aerodynamic braking. The graphical display comprises first indicia representing wind direction, second indicia representing main rotor roll control, third indicia representing main rotor pitch control, and fourth indicia representing a margin from main rotor flapping limit. The display cues a pilot with the proper direction in which to orient a rotor disk without exceeding main rotor flapping structural limitations.