Abstract: Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the structure of Formula I: Methods of inhibition MCT4 activity in a human or animal subject are also provided.

Abstract: A system and method for determining a reliability line rating for a transmission line is disclosed. In response to a line clearance measurement and a line temperature measurement received from a transmission line monitor coupled to a transmission line, the system generates a temperature-clearance model for the transmission line based on the received line clearance measurement and line temperature measurement. The system generates a plurality of past dynamic line ratings and determines a scaling factor based on the plurality of past dynamic line ratings. The system then generates a dynamic line rating for an interval of time in the future and scales the dynamic line rating in response to the scaling factor to obtain a reliability line rating for the interval.

Abstract: Systems and methods for sensing a train position of a train with no internal drive operating in an automated train system are provided. According to one embodiment, a train system comprises a track extending in a travel direction, a plurality of cars riding on the track and connected to form a train, a position sensing unit, and a programmable logic controller (PLC) in signal communication with the position sensing unit and configured to determine a train position based on inputs therefrom.

Abstract: The present invention generally relates to a rail transport system having no internal drive, and in particular to an improved rail transport system for conveying bulk materials. The rail transport system includes horizontal and vertical drive stations that include a drive tire that rotates on a plane parallel to the track. In this arrangement, force is applied on a different plane than earlier systems, and the reaction force is separated out of the tensioning device. The improvements of the drive stations provide for a reduction of steel used in the system, improved manufacturability and, therefore, reduction in system component costs as compared to previous drive stations. Moreover, the drive stations allow for improved maintainability and access to the drive tires.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the structure of Formula I: Methods of inhibition MCT4 activity in a human or animal subject are also provided.

Abstract: The present invention generally relates to a rail transport system having no internal drive, and in particular to an improved rail transport system for conveying bulk materials. The rail transport system includes improvements in functionality, manufacturability and/or modularity and, therefore, can result in a reduction in system component costs, manpower and/or implementation. The rail transport system includes a dump loop and components thereof for enabling unloading of the rail cars in a predetermined location. The components thereof may be designed to be modular to allow for ease of manufacture and installation of the dump loop. The components may be prefabricated for later use on site.

Abstract: In one embodiment, an improved programming system and language for application development is provided that combines elements of the C and Objective-C languages without the constraints imposed by a requirement to maintain compatibility with the C language. The language provides the functionality of the C language compatibility in certain areas to improve the inherent safety of software written in the language. The new language includes default safety considerations such as bounds and overflow checking.

Abstract: A dropped conductor sensor includes a housing installable on a first conductor; a sensor supported in the housing and configured to sense in real time at least one of an acceleration, a vibration, a tilt, a roll, or an angular displacement of the dropped conductor sensor; and an antenna in the housing, the antenna configured to transmit a signal including information sensed by the sensor away from the dropped conductor sensor in real time. A monitoring system including a dropped conductor sensor, and a method of monitoring a conductor using a dropped conductor sensor are also provided.

Abstract: The present invention generally relates to support frames and rail cars comprising first and second side drive plates, first and second cross members connecting the respective ends of the side drive plates, third and fourth cross members connecting the side drive plates at a select distance from the first and second cross members, a coupling assembly situated at the first cross member and adapted to connect another rail car thereto, and first and second diagonal support members connected to the first cross member at an angle sufficient to substantially direct forces from the coupling assembly to the third cross member and side drive plates. The support frames and rail cars may be used for conveying bulk materials on a rail transport system.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the structure of Formula I: Methods of inhibition MCT4 activity in a human or animal subject are also provided.

Abstract: In one embodiment, an improved programming system and language for application development is provided that combines elements of the C and Objective-C languages without the constraints imposed by a requirement to maintain compatibility with the C language. The language provides the functionality of the C language compatibility in certain areas to improve the inherent safety of software written in the language. The new language includes default safety considerations such as bounds and overflow checking.

Abstract: Mosquito bed net assembly 10a-h includes a mosquito bed net (12) impregnated with a first insecticide and a barrier member 16a-h located above an upper surface (14) of the bed net (12) and being impregnated with a second insecticide. In use, bed net assembly 16a-h increases the likelihood of delivering a lethal dosage of insecticide to mosquitoes flying in frequently-visited areas of a bed net, without increased attendant health risk to a user.

Abstract: Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

Abstract: In one embodiment, an improved programming system and language for application development is provided that combines elements of the C and Objective-C languages without the constraints imposed by a requirement to maintain compatibility with the C language. The language provides the functionality of the C language compatibility in certain areas to improve the inherent safety of software written in the language. The new language includes default safety considerations such as bounds and overflow checking.

Abstract: Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

Abstract: A method of controlling a pair of inverters connected in parallel and providing power to a motor. The speed of the motor is adjusted by varying the amplitude or frequency of the voltage supplied by each of the inverters to the motor. The method includes providing a system controller for controlling the frequency of the voltage supplied by each of the inverters. The frequency or amplitude setpoint of the voltage provided by each of the inverters is changed by sending a command signal from the system controller to each of the inverters in order to change the speed of the motor. The frequency or amplitude setpoint is controlled by a slew rate limiter.

Abstract: A system for supplying power to a motor driven pump. The system includes a variable speed electrical generator driven by an engine and a variable frequency drive connected to the output of the generator. The motor is powered by the output of the variable frequency drive. The system also includes a controller for changing the frequency of the output of the variable frequency drive and thereby changing the speed of the motor and the pump.

Abstract: A method of optimizing the dispatch of generators connected to an electrical grid. At least one of the gensets is a variable-speed genset. The optimum dispatch for each load condition is continuously updated by changing the load distribution slightly, testing for performance improvement and updating the distribution set points if improvement is found. Alternatively, the power system may be controlled so that the optimum dispatch for each load condition is determined with the use of an online model that is continuously updated with actual operational data to thereby determine the optimum dispatch.

Abstract: A generator system including an engine and an electrical generator. An electronic control unit configured to monitor and control the engine and generator is provided. The electronic control unit is configured to monitor the electrical load being supplied by the generator and to determine whether the load has remained within a predetermined range for a predetermined period of time. The electronic control unit is configured to adjust the speed of the engine by a predetermined amount when the load has been determined to have remained within the predetermined range for a predetermined length of time. The electronic control unit is configured to compare the present rate of fuel consumption for the adjusted speed to a stored value for the rate of fuel consumption corresponding to the present electrical load being applied to the generator and subsequently update the stored value for engine speed based on the results of the comparison.

Abstract: In one embodiment, an improved programming system and language for application development is provided that combines elements of the C and Objective-C languages without the constraints imposed by a requirement to maintain compatibility with the C language. The language provides the functionality of the C language compatibility in certain areas to improve the inherent safety of software written in the language. The new language includes default safety considerations such as bounds and overflow checking.