Abstract: Provided herein are methods for identification of antigen binding molecules such as antibodies from a sample by exposing the antigen binding molecules to an antigen conjugated to an oligonucleotide.

Abstract: An injector system for delivering a medical fluid may include at least one syringe defining a reservoir operatively connected to a piston; and at least one processor programmed or configured to, based on an air check protocol for detecting air in the reservoir, determine a baseline value comprising baseline compressibility data for the at least one syringe of the injector system, deliver the first amount of the medical fluid from the reservoir; refill the reservoir with a second amount of the medical fluid; based on the air check protocol, perform an air check pressurization sequence by gathering air check compressibility data for the at least one syringe of the injector system; and based on the air check protocol, compare the air check compressibility data with the baseline compressibility data to determine a volume of air present in the reservoir.

Abstract: A device for providing respiratory gases comprises a blower configured to receive a first gas from a first gas flow path and generate a flow of a first gas provided through a first gases outlet of the blower; a second gas flow path configured to receive a flow of a second gas and provide the flow of the second gas through a second gases outlet; and a mixing chamber configured to receive a flow of the first gas from the first gases outlet and a flow of the second gas from the second gases outlet. The received gases are configured to mix in the mixing chamber to form a mixed gas. The received gases are configured to travel in a mixing flow direction in the mixing chamber towards a mixed gases inlet, wherein mixed gas exits the mixing chamber via the mixed gases inlet providing flow to a mixed gas flow path.

Abstract: A self-shielded and computer controlled system for performing non-invasive stereotactic radiosurgery and precision radiotherapy using a linear accelerator mounted within a two degree-of-freedom radiation shield coupled to a three-degree of freedom patient table is provided. The radiation shield can include an axial shield rotatable about an axial axis and an oblique shield independently rotatable about an oblique axis, thereby providing improved range of trajectories of the therapeutic and diagnostic radiation beams. Such shields can be balanced about their respective axes of rotation and about a common support structure to facilitate ease of movement. Such systems can further include an imaging system to accurately deliver radiation to the treatment target and automatically make corrections needed to maintain the anatomical target at the system isocenter.

Abstract: A fluid injector system and method for preventing pressurized backflow of a second fluid into a first reservoir containing a fluid is described. The fluid injector system includes a control device programmed or configured to actuate a second drive component to pressurize and inject the second fluid through the fluid conduit, and while the second drive component is actuated, actuate a first drive component to introduce intermittent pulses of the first fluid to create a flow front interface between the first fluid and the second fluid in the fluid conduit to prevent backflow of the second fluid through the fluid conduit into the first fluid reservoir.

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.

Abstract: An apparatus including a sterilizable tray having a base and at least one fixture connected to the tray adapted for removably securing an implant insertion device to the tray. The tray can be free of a first wall portion for permitting the proximal end of an implantable device to axially align with the end of the implant insertion device for coupling to the implant insertion device and can be free of a second wall portion for permitting a tool to axially align with the end of the implant insertion device so as to threadedly couple the implant insertion device to the implantable device. Related methods and apparatus are provided.

Abstract: A portable davit includes a base having a mounting portion and a housing. The housing defines a cavity. An end of a mast is positioned within the cavity. A jib is coupled to another end of the mast. A connector is coupled to the jib. A hoist is coupled to a platform and includes a drive and a rope. An end of the rope is wound about the drive. Another end of the rope is coupled to the connector. The drive is configured to rotate relative to the platform in a first direction to decrease a distance between the platform and an end of the jib and to rotate relative to the platform in an opposite second direction to increase the distance between the platform and an end of the jib. Systems and methods of use are provided.

Abstract: A portable davit includes a base having a mounting portion and a housing. The housing defines a cavity. An end of a mast is positioned within the cavity. A jib is coupled to another end of the mast. A connector is coupled to the jib. A hoist is coupled to a platform and includes a drive and a rope. An end of the rope is wound about the drive. Another end of the rope is coupled to the connector. The drive is configured to rotate relative to the platform in a first direction to decrease a distance between the platform and an end of the jib and to rotate relative to the platform in an opposite second direction to increase the distance between the platform and an end of the jib. Systems and methods of use are provided.

Abstract: A portable davit includes a base having a mounting portion and a housing coupled to the mounting portion. The housing include an inner surface defining a cavity. A hoist is positioned within the cavity. The hoist includes a drive and a rope. The rope includes opposite first and second ends. The first end of the rope is wound about the drive. A mast includes opposite first and second ends. The first end of the mast is positioned within the cavity. The mast includes an inner surface defining a passageway. A jib includes opposite first and second ends. The first end of the jib is coupled to the second end of the mast. The second end of the rope extends through an opening in the second end of the jib.

Abstract: An apparatus including a sterilizable tray having a base and at least one fixture connected to the tray adapted for removably securing an implant insertion device to the tray. The tray can be free of a first wall portion for permitting the proximal end of an implantable device to axially align with the end of the implant insertion device for coupling to the implant insertion device and can be free of a second wall portion for permitting a tool to axially align with the end of the implant insertion device so as to threadedly couple the implant insertion device to the implantable device. Related methods and apparatus are provided.

Abstract: A stent graft system includes a stent graft, a radially expandable scaffold, and an inflatable fill structure. The stent graft includes a body portion with a plurality of pleated sections that are configured to be extended from a telescopically compressed state to a longitudinally extended state. The radially expandable scaffold is attached to a top of the body portion, and has one or more fixation elements for penetrating into an aortic wall. The inflatable fill structure is attached at a top of the body portion and is configured to expand in a longitudinal direction as the body portion is extended in the longitudinal direction. The inflatable fill structure is also configured to expand in a radial direction to contact an inner surface of a blood vessel.

Abstract: An apparatus including a sterilizable tray having a base and at least one fixture connected to the tray adapted for removably securing an implant insertion device to the tray. The tray can be free of a first wall portion for permitting the proximal end of an implantable device to axially align with the end of the implant insertion device for coupling to the implant insertion device and can be free of a second wall portion for permitting a tool to axially align with the end of the implant insertion device so as to threadedly couple the implant insertion device to the implantable device. Related methods and apparatus are provided.

Abstract: An apparatus including a sterilizable tray having a base and at least one fixture connected to the tray adapted for removably securing an implant insertion device to the tray. The tray can be free of a first wall portion for permitting the proximal end of an implantable device to axially align with the end of the implant insertion device for coupling to the implant insertion device and can be free of a second wall portion for permitting a tool to axially align with the end of the implant insertion device so as to threadedly couple the implant insertion device to the implantable device. Related methods and apparatus are provided.

Abstract: Methods and apparatus for optimizing operation of a combined cycle power plant which combines the use of both gas and steam turbines in a single power generating plant. In one embodiment there is provided a closed-loop hybrid neural network-first principles optimizer for optimally allocating fuel across power generation plant blocks and sub systems to minimize fuel costs while meeting capacity and ramp-rate commitments. Embodiments of the methods and apparatus include a steady state plant optimization model and a dynamic plant optimization model.

Abstract: A portable container lift or weighing system includes lifting units, each including a hydraulic linear actuator and a mounting arrangement for mounting the actuator to a shipping container. The system includes a number of portable components that can be handled by a single worker. The system may provide a means for weighing the container.

Abstract: Ice for use in a beverage, wherein the ice comprises a core, an active zone, an external surface, and caffeine. The ice particle has a depth from each point of the external surface extending perpendicularly inwards. It also has a total particle mass. The caffeine in the ice particle has a total caffeine mass, and the ice particle has an ice caffeine concentration equal to the total caffeine mass divided by the total particle mass. The active zone includes at least 40% of the total caffeine mass and local caffeine concentrations of at least 150% of the ice caffeine concentration. At least 67% of the total caffeine mass is contained within a caffeine depth in millimeters from the external surface no greater than 1.06 times the cube root of the total particle mass in grams. The core has local caffeine concentrations of less than 150% of the ice caffeine concentration.

Abstract: A container for dispensing into a fuel receptacle can include a neck through which a product is flowed, and threads which merge with a circumferentially continuous shoulder spaced apart from the neck. The neck disengages a lock which secures a closure of the fuel receptacle, in response to insertion of the container into the fuel receptacle. Another container can include a neck through which a product is flowed, and threads which merge with a circumferentially continuous shoulder spaced apart from the neck, the shoulder having a circumferentially continuous surface that faces an annular recess separating the shoulder from the neck. A method of discharging a fuel additive into a fuel receptacle is also disclosed.

Abstract: A double pipe configuration for an HVAC system comprising an outer pipe, where the outer pipe is a hot gas exhaust pipe; an inner pipe positioned within the outer pipe, where the inner pipe is a cold air intake pipe, and where the cold air of the inner pipe is warmed by the hot exhaust of the outer pipe; and a plurality of radial fins to support the inner pipe within the outer pipe, where the radial fins redirect the heat within the outer pipe to warm the cold air within the inner pipe. The double pipe configuration may also be configured with a 90 degree elbow structure or a 45 degree bend structure to allow for the pipe to be positioned around objects.

Abstract: A sootblowing control system that uses predictive models to bridge the gap between sootblower operation and boiler performance goals. The system uses predictive modeling and heuristics (rules) associated with different zones in a boiler to determine an optimal sequence of sootblower operations and achieve boiler performance targets. The system performs the sootblower optimization while observing any operational constraints placed on the sootblowers.