Abstract: The present disclosure generally relates to methods and systems for engineering antibodies, and antigen-binding fragments thereof, to have altered characteristics. The present disclosure also provides a high-throughput method useful for identifying the engineered antibodies, or antigen-binding fragments thereof, that acquired the altered characteristics having performed the methods. These methods and systems have implications, for example, in the rapid development of biotherapeutics having desired and/or improved, e.g., affinity, specificity and/or activity-related, characteristics.

Abstract: The cooling systems and methods of the present disclosure relate to cooling electronic equipment in data centers or any other applications that have high heat rejection temperature and high sensible heat ratio.

Abstract: Ophthalmic suture materials made from biocompatible and biodegradable polymers with high tensile strength for use in drug delivery, methods of making them, and method of using them for ocular surgery and repair have been developed. The suture materials are made from a combination of a biodegradable, biocompatible polymer and a hydrophilic biocompatible polymer. In a preferred embodiment the suture materials are made from a poly(hydroxyl acid) such as poly(1-lactic acid) and a polyalkylene oxide such as poly(ethylene glycol) or a polyalkylene oxide block copolymer. The sutures entrap (e.g., encapsulate) one or more therapeutic, prophylactic or diagnostic agents and provide prolonged release over a period of at least a week, preferably a month.

Abstract: A predicted size of a specific subject and a predicted size of a specific item are determined using one or more machine learning models. The machine learning models are trained using at least a specified size of the specific subject, feedback of the specific subject regarding sizing of a plurality of items, and feedback of other subjects regarding sizing of the plurality of items. The determined predicted size of the specific subject and the predicted size of the specific item are used to determine a predicted size fit between the specific item and the specific subject.

Abstract: A laminate structure includes a base layer, a thermally stable adhesive disposed on at least a portion of the base layer, and a thermally stable film overlying the base layer and the adhesive. The thermally stable film and the thermally stable adhesive are configured such that the laminate structure substantially resists deformation at a temperature of about 400° F. (204° C.) and above.

Abstract: Ophthalmic suture materials made from biocompatible and biodegradable polymers with high tensile strength for use in drug delivery, methods of making them, and method of using them for ocular surgery and repair have been developed. The suture materials are made from a combination of a biodegradable, biocompatible polymer and a hydrophilic biocompatible polymer. In a preferred embodiment the suture materials are made from a poly(hydroxyl acid) such as poly(1-lactic acid) and a polyalkylene oxide such as poly(ethylene glycol) or a polyalkylene oxide block copolymer. The sutures entrap (e.g., encapsulate) one or more therapeutic, prophylactic or diagnostic agents and provide prolonged release over a period of at least a week, preferably a month.

Abstract: Ophthalmic suture materials made from biocompatible and biodegradable polymers with high tensile strength for use in drug delivery, methods of making them, and method of using them for ocular surgery and repair have been developed. The suture materials are made from a combination of a biodegradable, biocompatible polymer and a hydrophilic biocompatible polymer. In a preferred embodiment the suture materials are made from a poly(hydroxyl acid) such as poly(l-lactic acid) and a polyalkylene oxide such as poly(ethylene glycol) or a polyalkylene oxide block copolymer. The sutures entrap (e.g., encapsulate) one or more therapeutic, prophylactic or diagnostic agents and provide prolonged release over a period of at least a week, preferably a month.

Abstract: In one aspect, a fuel injector includes an injector body that defines a fuel inlet, a drain outlet and a nozzle outlet. A direct operated check valve is positioned in the injector body and includes a needle valve member with an opening hydraulic surface exposed to fluid pressure in a nozzle supply passage, and a closing hydraulic surface exposed to fluid pressure in a needle control chamber. The needle valve member is movable between a first position at which the nozzle supply passage is blocked to the nozzle outlet, and a second position at which the nozzle supply passage is open to the nozzle outlet. A needle control valve is positioned in the injector body and includes a control valve member movable between a first position at which the needle control chamber is fluidly connected to the drain outlet, and a second position at which the needle control chamber is fluidly blocked to the drain outlet.

Abstract: An embodiment in accordance with the present invention provides a device and method for providing HA to the ocular environment. A contact lens according to the present invention is treated at its surface with a HA binding peptide. The HA binding peptide can be covalently bonded to a functional group on the surface of the contact lens, such as OH, COOH, or NH2. The lens can then be pretreated with HA for immediate increased wearer comfort upon insertion of the lens. As HA is washed away or degraded from the surface of the lens, the HA binding peptide remains and therefore HA can be replenished from endogenous or exogenous sources.

Abstract: In one aspect, a fuel injector includes an injector body that defines a fuel inlet, a drain outlet and a nozzle outlet. A direct operated check valve is positioned in the injector body and includes a needle valve member with an opening hydraulic surface exposed to fluid pressure in a nozzle supply passage, and a closing hydraulic surface exposed to fluid pressure in a needle control chamber. The needle valve member is movable between a first position at which the nozzle supply passage is blocked to the nozzle outlet, and a second position at which the nozzle supply passage is open to the nozzle outlet. A needle control valve is positioned in the injector body and includes a control valve member movable between a first position at which the needle control chamber is fluidly connected to the drain outlet, and a second position at which the needle control chamber is fluidly blocked to the drain outlet.

Abstract: In one aspect, a fuel injector includes an injector body that defines a fuel inlet, a drain outlet and a nozzle outlet. A direct operated check valve is positioned in the injector body and includes a needle valve member with an opening hydraulic surface exposed to fluid pressure in a nozzle supply passage, and a closing hydraulic surface exposed to fluid pressure in a needle control chamber. The needle valve member is movable between a first position at which the nozzle supply passage is blocked to the nozzle outlet, and a second position at which the nozzle supply passage is open to the nozzle outlet. A needle control valve is positioned in the injector body and includes a control valve member movable between a first position at which the needle control chamber is fluidly connected to the drain outlet, and a second position at which the needle control chamber is fluidly blocked to the drain outlet.

Abstract: Ophthalmic suture materials made from biocompatible and biodegradable polymers with high tensile strength for use in drug delivery, methods of making them, and method of using them for ocular surgery and repair have been developed. The suture materials are made from a combination of a biodegradable, biocompatible polymer and a hydrophilic biocompatible polymer. In a preferred embodiment the suture materials are made from a poly(hydroxyl acid) such as poly(l-lactic acid) and a polyalkylene oxide such as poly(ethylene glycol) or a polyalkylene oxide block copolymer. The sutures entrap (e.g., encapsulate) one or more therapeutic, prophylactic or diagnostic agents and provide prolonged release over a period of at least a week, preferably a month.

Abstract: A method of manufacturing an edible product, and a baked product itself, is provided that includes mixing and kneading ingredients having wheat flour, water, sugar, salt, mono and diglycerides, yeast, calcium propionate, sorbic acid, cornmeal, guar gum, wheat, gluten, and citric acid into a dough. The dough is then formed into a uniform rod having end portions. The end portions are then connected to form a circular-shaped element. The circular-shaped element is then fermented to a desired size and is then boiled in a sodium hydroxide bath for a period of time to produce a color that is between a yellow and an orange hue. The circular-shaped element is then baked, followed by spraying the circular-shaped element with a preservative formulation, and then cooling the circular-shaped element.

Abstract: A dough sheeting system for sheeting highly viscous bagel dough is presented. A continuous sheet of bagel dough is sheeted on a sheeting table including a satellite roller device, a cross roller device, and a gauging roller device arranged in series. The sheeting table reduces the dough sheet to a final thickness and width before a slitting device incorporating a plurality of rotary disc cutters, cuts the dough sheet into a plurality of dough sheets. Then a docker device cuts and virtually simultaneously presses the plurality of dough sheets to create a depressed center portion. A second cycle of the docker device cuts and presses again the depressed center portions of each newly created bagel dough piece. A spreading belt conveyor, a reciprocating conveyor, and a board indexing conveyor transport the bagel dough pieces to a proofing board for proofing and processing.

Abstract: Keratocyte loss after trauma or injury to the corneal epithelium is prevented or reduced by applying to the corneal epithelium a keratocyte maintenance solution over a period of time sufficient to permit corneal wound healing. The keratocyte maintenance solution is applied to the cornea after trauma (for example, removal of the epithelium prior to surgery, such as photorefractive keratectomy). Preferably, the solution is maintained over the cornea by means of a fluid bath or by means of an absorbent material effective for controlled release of the solution to the cornea (e.g., a collagen shield substantially in the form of a conventional contact lens). A preferred keratocyte maintenance solution is a corneal storage medium.

Abstract: A display box has first and second opaque sides meeting at a corner and defining a window opening extending around the corner. A semi-rigid transparent sheet in the window opening overlaps portions of the first and second opaque sides adjacent the window opening and is secured thereto. The transparent sheet has a main fold line extending across the window opening in line with the corners and a corner portion at at least one end of the main fold line. The or each corner portion is formed by a first corner fold line in the transparent sheet adjacent the first opaque side and extending from the window opening to an adjacent end of the transparent sheet, a second corner fold line in the transparent sheet adjacent the second opaque side and extending from the window opening to the adjacent end of the transparent sheet, and a third corner fold line in the transparent sheet between the first and second fold lines and extending from the window opening to the adjacent end of the transparent sheet.