Abstract: A method for generating high power pulsed RF waveforms comprises the steps of charging a transmission line in a pulse forming network with a high-voltage and discharging the voltage on the transmission line to ground utilizing a gallium nitride photoconductive switch.

Abstract: A method for generating high power pulsed RF waveforms comprises the steps of charging a transmission line in a pulse forming network with a high-voltage and discharging the voltage on the transmission line to ground utilizing a gallium nitride photoconductive switch.

Abstract: The present invention relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhancing agent (PSEA) to form a solution in a single liquid phase. The solution is subjected to a liquid-solid phase separation to cause the active agent to form small spherical that are substantially amorphous or non-crystalline and are injectable through fine gauge needles at high concentrations. The invention has special application for higher molecular weight proteins.

Abstract: Compositions of spherical insulin particles having improved pulmonary application potentials and methods of forming and using these compositions are disclosed in the present application. In one clinical trial with 30 healthy male human subjects, no coughing was observed upon a single pulmonary administration of the spherical insulin particles at an insulin dose of 6.5 mg, nor during the 10-hour post dosing period.

Abstract: The present invention relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhancing agent (PSEA) to form a solution in a single liquid phase. The solution is subjected to a liquid-solid phase separation to cause the active agent to form small spherical that are substantially amorphous or non-crystalline and are injectable through fine gauge needles at high concentrations. The invention has special application for higher molecular weight proteins.

Abstract: The present invention is related to a method for preparing small spherical particles of an active agent by providing a solution in a single liquid phase. The single liquid phase comprises an active agent, a phase separation enhancing agent, and a first solvent. A phase change is induced at a controlled rate in the solution to cause a liquid-solid phase separation of the active agent and to form a solid phase and a liquid phase. The solid phase comprises solid small spherical particles of the active agent. The liquid phase comprises the phase separation enhancing agent and the solvent. The small spherical particles are substantially spherical and having a size from about 0.01 ?m to about 200 ?m.

Abstract: The present invention is related to a method for preparing small spherical particles of an active agent by providing a solution in a single liquid phase. The single liquid phase comprises an active agent, a phase separation enhancing agent, and a first solvent. A phase change is induced at a controlled rate in the solution to cause a liquid-solid phase separation of the active agent and to form a solid phase and a liquid phase. The solid phase comprises solid small spherical particles of the active agent. The liquid phase comprises the phase separation enhancing agent and the solvent. The small spherical particles are substantially spherical and having a size from about 0.01 ?m to about 200 ?m.

Abstract: The invention provides homogeneous small spherical particles of low molecular weight organic molecules, said small spherical particles having a uniform shape, a narrow size distribution and average diameter of 0.01-200 ?m. The invention further provides methods of preparation and methods of use of the small spherical particles. These small spherical particles are suitable for applications that require delivery of micron-size or nanosized particles with uniform size and good aerodynamic or flow characteristics. Pulmonary, intravenous, and other means of administration are among the delivery routes that may benefit from these small spherical particles.

Abstract: A method and apparatus of forming a preform (12) of structural fibers (14) includes a hermetically sealed housing (18) for controlling air pressures and flow therein. A perforated screen (28) is located within the housing (18) separating same into a high pressure chamber (34) and a low pressure chamber (36). Pressurized air is supplied to the high pressure chamber (34) to agitate and randomize fibers (14), and a vacuum (26) is provided in the low pressure chamber (36) to draw and compact the fibers against the screen (28). The pressure differential between the chambers (34, 36) provides significant compaction of the fibers against the screen. A binder (16) is applied to the fibers (14) to maintain the shape of the preform.