Abstract: The invention relates to the use of one or more compounds of the formula (I) or salts thereof, (I) wherein the groups R1 to R3, X2 to X6, Z and G are defined as set forth in claim 1, optionally in the presence of additional agrochemical active ingredients, for spot-treatment application against weeds of an agricultural field where a plurality of crop plants grow, have been sown, have transplanted, are to be sown and/or are to be transplanted.

Abstract: A method of managing a license for a software module of a vehicle having a plurality of operating states includes receiving, by a processor, license term data of the license. The license term data includes an expiration time limit of the license. The method also includes observing, by a sensor, a condition of the vehicle. Additionally, the method includes determining, by the processor, an operating state of the vehicle based on the condition observed by the sensor. Furthermore, the method includes determining, by the processor, whether to deny access to the software module according to the expiration time limit based on the determined operating state.

Abstract: A method of managing a license for a software module of a vehicle having a plurality of operating states includes receiving, by a processor, license term data of the license. The license term data includes an expiration time limit of the license. The method also includes observing, by a sensor, a condition of the vehicle. Additionally, the method includes determining, by the processor, an operating state of the vehicle based on the condition observed by the sensor. Furthermore, the method includes determining, by the processor, whether to deny access to the software module according to the expiration time limit based on the determined operating state.

Abstract: The present invention relates to the treatment and prevention of the toxic effects associated with increased nitric oxide synthase activity in endothelial cells. In particular, the present invention relates to compounds and methods of treatment that inhibit the nitric oxide synthases present in endothelial cells and methods for treating diseases using such compounds and methods.

Abstract: Compounds, genetic constructs, and cancer treatment methods are provided. Expression vectors were designed to express fusion genes including hIL-2 with a Fc?-? transmembrane anchor derived from a subunit of the FC epsilon receptor. mRNA and the IL-2tm fusion protein was expressed in transfected RD995 tumor cells. Expression of the IL-2tm protein on the tumor cell surface membrane was confirmed by microscopy. RD995 cells transfected with IL-2tm or pCMV2b (empty expression vector) were implanted subcutaneously into C3H/HEN mice. Tumors of mice implanted with 106 or 105 RD995 cells transfected with IL-2tm grew slower than controls. It is believed that selective expression of cytokines such as IL-2 on the surface of tumors is likely to stimulate tumor-infiltrating lymphocytes that are primed and already recognize tumor antigens, enhancing tumor recognition and killing, potentially avoiding toxicity associated with known cytokine therapies.

Abstract: Compounds, genetic constructs, and cancer treatment methods are provided. Expression vectors were designed to express fusion genes including hIL-2 with a Fc?-? transmembrane anchor derived from a subunit of the FC epsilon receptor. mRNA and the IL-2tm fusion protein was expressed in transfected RD995 tumor cells. Expression of the IL-2tm protein on the tumor cell surface membrane was confirmed by microscopy. RD995 cells transfected with IL-2tm or pCMV2b (empty expression vector) were implanted subcutaneously into C3H/HEN mice. Tumors of mice implanted with 106 or 105 RD995 cells transfected with IL-2tm grew slower than controls. It is believed that selective expression of cytokines such as IL-2 on the surface of tumors is likely to stimulate tumor-infiltrating lymphocytes that are primed and already recognize tumor antigens, enhancing tumor recognition and killing, potentially avoiding toxicity associated with known cytokine therapies.

Abstract: A method for funding infrastructure or building initiatives, such as a transport initiative, includes collecting payments from parties who stand to financially benefit from the initiative and using these payments to partly or wholly fund the initiative.

Abstract: The present invention relates to the fields of biology and pharmacology. This invention relates, generally, to methods and compositions for modulating oxLDL activity or transport. The present invention resides more specifically in methods for screening compounds that modulate oxLDL activity, more particularly oxLDL cellular uptake. The present invention more particularly describes novel methods of selecting or identifying compounds that can modulate oxLDL cellular binding, uptake and/or degradation by CD36 polypeptides and especially CD36 polypeptides comprising a functional cytoplasmic domain in various cells, such as macrophages. The invention also relates to the use of such compounds, in particular for research, development, improvement, diagnosis, therapeutic or prohylactic treatment of various pathological conditions.

Abstract: A bag filling machine comprising a supply hopper, a material flow control mechanism and a rotatable bag filling spout is herein disclosed. The rotating bag filling spout is constructed and arranged for rotation about a vertical axis and is connected to the supply hopper through the material flow control mechanism so as to convey bulk commodities stored in the supply hopper into a bag that is to be filled. After the bag has been filled, the rotatable bag filling spout rotates to close the bag. A sealing mechanism is also provided to seal the filled bags once they have been closed by the rotating bag filling spout.

Abstract: An electronic device for displaying question data and answer data includes an input device for entering commands, first and second displays, and a processor. The question data is displayed on the first display which is visible to an operator of the electronic device and on a second display which is visible from a position from which the first display is not visible, i.e., the position of an observer such as a student. The operator can selectively control the displaying of the answer data on each of the displays using commands entered on the input device. Entry of a first command causes the answer data to be display only on the first display so that the answer is visible only to the operator. Entry of a second command causes the answer data to be displayed on the second display so that the observer can also see the answer. In one mode of operation, the question and answer data for many questions is stored in a storage device, and the questions are categorized by level of difficulty or by subject.