Abstract: Procedures are described which use solvents to increase the topical insecticidal activity of toxic insect peptides. These procedures comprise drying the peptides, if needed, followed by the addition of either: 1) a polar organic solvent, with or without water, to a dried peptide, or 2) the addition of polar aprotic solvent or other adjuvant to the dried peptide, followed by the addition of either: 1) a polar organic solvent, with or without water, (where a polar aprotic solvent is added first) or 2) a polar aprotic solvent or other adjuvant to the peptide polar organic solvent (where the polar organic solvent is added first), to the peptide formulation.

Abstract: The present invention is directed to a biomarker and kit for diagnosing, monitoring and/or staging Alzheimer's disease comprising redox-reactive autoantibodies. The present invention is also directed to a method for diagnosing, monitoring and/or staging Alzheimer's disease which comprises conducting a blood test using the same.

Abstract: The binding specificity of a monoclonal antibody is altered by exposing the monoclonal antibody to an oxidizing agent or an electric potential.

Abstract: The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium is altered by exposing the protein to an oxidizing agent or an electric current sufficient to alter its binding specificity. A masked protein such as an autoantibody can be recovered from blood or blood products or extracts by oxidizing the protein to change its binding specificity.

Abstract: Methods for the treatment of ischemic limbs. An energy source, which will typically be a laser energy source deployed through an optic fiber, is deployed subcutaneously to a site of ischemic skeletal muscle. At the site, a plurality of channels are preferably systematically formed with an appropriate amount of activated energy, which in turn can facilitate the restoration of blood flow through new blood vessel formation. Optionally, a needle or cannula can be deployed in conjunction with the energy source to help facilitate the formation of channel formation and/or deliver a therapeutic agent at the sight of channel formation. A sheath may also be utilized to house the optic fiber and deliver a therapeutic agent.

Abstract: The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium is altered by exposing the protein to an oxidizing agent or an electric current sufficient to alter its binding specificity. A masked protein such as an autoantibody can be recovered from blood or blood products or extracts by oxidizing the protein to change its binding specificity.

Abstract: A novel brake assembly is provided for a bicycle. The assembly is composed of an arrangement of a pair of brake pads each connected to a rod member in turn guided for axial movement by a base fixed on the bicycle frame. A bifurcated control cable actuates wedge members causing movement of the pads against a wheel rim. Return springs on the rod members cause the assembly to return to the original non-braking position in response to release of the control cable. As an option, a second wedge action can be incorporated that is activated by the frictional forces generated from the contact of the brake pads with the wheel rim. The second wedge action is limited by a mechanical stop within the brake assembly to prevent jamming of the brakes.

Abstract: The present invention 10 discloses a bridge cap comprising a compressible resilient material having a substantially oval shape with a planar surface on the distal ends 24 thereof. The bridge cap 10 has a cavity 28 with a pliable material 30 therein whereby the bridge cap can be releasably positioned on protruding pins 16 such that the pins extending from the fixator devices can be covered to prevent inadvertent potentially damaging contact with the protruding pins especially while sleeping.

Abstract: The present invention contemplates an elongated surgical guide shaft for placement within a body and surgical devices containing such a guide shaft. The shaft includes both a flexible portion and a gripping portion. The gripping portion is adapted to be handled or gripped by surgical tools and is resistant to crushing. The present invention also contemplates a method for performing a minimally invasive surgery. The method includes inserting a surgical device including such a guide shaft into a patient, grasping the gripping section of the guide shaft with a surgical tool in order to aid proper placement of the guide shaft, and using the surgical device to treat the patient.

Abstract: The present invention contemplates a surgical device for both ablating a channel in a patient's tissue and also delivering a therapeutic agent. The device includes an elongated multi-lumen tube, an elongated tissue ablating assembly, and a therapeutic agent delivery assembly. The therapeutic agent is capable of being delivered into the channel and/or to the surrounding tissue. The device may further include a second multi-lumen tube also capable of delivering therapeutic agents. Although suitable for many operations, the device is particularly well suited for transmyocardial revascularization operations. The present invention also contemplates a procedure for using such a surgical device to ablate a channel in a patient's tissue and also deliver a therapeutic agent.

Abstract: A device for performing a surgical procedure within a body and a method for utilizing such a device to treat a patient's heart with minimal invasiveness. The device comprises a handle, a guide shaft, and a sleeve in slideable connection with the guide shaft. The guide shaft is connected to the handle at a proximal portion and has a first curved position at the distal portion. Slideable manipulation of the sleeve changes the first curved position. The method comprises providing such a device, introducing the device into a minimally invasive port in the patient, and providing treatment to the patient's heart.

Abstract: A neurodegenerative disease or condition is diagnosed in a subject by obtaining a sample of cerebral spinal fluid from the subject and assaying the sample by an assay method that detects the presence of at least one antiphospholipid autoantibody in the sample, wherein an elevated level of at least one antiphospholipid autoantibody in the sample of cerebral spinal fluid correlates with a neurodegenerative disease or condition in the subject. The neurodegenerative disease or condition may also be diagnosed by assaying a sample of cerebral spinal fluid to detect nitrosylated antibodies, wherein an elevated level of nitrosylated antibodies correlates with a neurodegenerative disease or condition in said subject.

Abstract: An assay device is made by combining a polynucleic acid with a molten material capable of solidifying into a solid thermoplastic or thermosetting material and then allowing the molten material to solidify. The thus-formed thermoplastic solid material has at least some molecules of the polynucleic acid exposed on the surface of the thermoplastic solid material in an orientation wherein the polynucleic acid is bindable to a binding partner by specific binding. The invention further relates to a solid phase substrate having a polynucleic acid embedded therein. The invention further relates to the use of a solid phase substrate having a polynucleic acid embedded therein for hybridization assays and immunoassays to detect anti-nucleic acid antibodies.

Abstract: A lighted fishing net is provided which uses a clear hollow frame around the perimeter of the net. A light source, such as an incandescent lamp, mounted internally to the frame, then illuminates the frame from within. A second light source, similar to a flashlight bulb in a reflector, is positioned at the top of the handle at the frame end to shine into the net area. The handle of the invention is made of hollow plastic to allow the invention to float as well as to contain the batteries. A three-way switches has three separate control positions: one to activate the frame light; one to activate the handle light; and one to turn them both off. It is also envisioned that the handle would fold in half to save storage space.

Abstract: The binding specificity of at least one protein suspended or dissolved in a liquid medium is reversibly altered by exposing the protein to an oxidizing agent or an electric current. A masked protein such as an autoantibody can be detected, isolated and recovered from a biological fluid by subjecting the biological fluid to an oxidizing agent or an electric current to change the binding specificity of masked proteins contained therein.

Abstract: A device and method for aligning a media sheet moving along a media path. An amount of skew that will occur as the media sheet moves along the media path is determined based on one or more physical characteristics. Previous testing of the device indicates that media sheets having particular physical characteristics will have a known amount of skew by the time they reach a predetermined location along the media path. The media sheet is moved the known amount so the media sheet is aligned. Test data is used to determine the amount of expected misalignment of the media sheet and the amount necessary to move the media sheet back into alignment.

Abstract: A novel brake assembly is provided for a bicycle. The assembly is composed of an arrangement of a pair of brake pads each connected to a rod member in turn guided for axial movement by a base fixed on the bicycle frame. A bifurcated control cable actuates wedge members causing movement of the pads against a wheel rim. Return springs on the rod members cause the assembly to return to the original non-braking position in response to release of the control cable.

Abstract: The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium is altered by exposing the protein to an oxidizing agent or an electric current sufficient to alter its binding specificity. A masked protein such as an autoantibody can be recovered from blood or blood products or extracts by oxidizing the protein to change its binding specificity.

Abstract: A tape-reinforced tubular vascular graft formed of sintered fluoropolymer(s), such as expanded, sintered PTFE. The graft includes a base graft and a reinforcing tape applied thereto. The tape may be spirally wrapped about the graft or spirally wrapped into a tube about a cylindrical mandrel and then applied to the exterior of the graft. Radial shrinkage of the combined base graft and tape, or of the reinforcing tape tube, renders the vascular graft subsequently radially enlargeable by more than 5%, without tearing or breaking of the reinforcement tape layer of the graft. Radially enlargeable grafts of the present invention may be combined with various types of stents or anchoring systems, to form endovascular graft devices which are transluminally insertable and implantable within the lumen of a host blood vessel.

Abstract: The invention relates to an immunoassays, binding assays, solid phase substrates (12) and other devices with an antigen or antibody or ligand or receptor (11) embedded into a solid phase substrate (12). The antigen or antibody is mixed with a molten thermoplastic and formed into the solid phase substrate (12).