Abstract: The present application relates to compounds of formula (I), (Ia), or (Ib) and their pharmaceutical compositions/preparations. This application further relates to methods of treating or preventing A?-related pathologies such as Down's syndrome, ?-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI (“mild cognitive impairment”), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia, including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease.

Abstract: In one embodiment, a method includes receiving one or more audio/visual recordings from a user, the audio/visual recordings continuously capturing audio/visual information around the user, the audio/visual recordings being made by a client computing device of the user automatically and without manual user input and with one or more sensors of the client computing device; processing the audio/visual recordings to extract one or more audio/visual segments, each audio/visual segment covering a specific time period or relating to a specific event in the user's life; and posting the audio/visual segments to one or more points, respectively, along a timeline corresponding to the user's life.

Abstract: In one embodiment, a method includes receiving first information about a proximity of a first user, the first information comprising one or more images or one or more sounds of at least a portion of the proximity, the first information having been obtained from the proximity by a client computing device of the first user automatically and with one or more sensors of the client computing device; identifying a second user within the proximity of the first user based at least in part on the first information; retrieving second information about the second user from a graph of a social-networking system, the graph comprising a plurality of nodes and edges connecting the nodes, at least one node in the graph corresponding to the first user, at least one node in the graph corresponding to the second user; and sending the second information about the second user to the first user.

Abstract: In particular embodiments, one or more computer systems of a social-networking system determine identities of one or more users in proximity to a display device and query a social graph of the social-networking system for social content associated with the determined identities. The social graph includes nodes and edges connecting the nodes. The nodes include user nodes that are each associated with a particular user of the social-networking system. The one or more computer systems of the social-networking system identify, using the social content, recommended media content for the one or more users in proximity to the display device and provide a playlist for display on the display device. The playlist includes the recommended media content for the one or more users in proximity to the display device.

Abstract: A method including, by a computing device, receiving an indication of an electronic communication from a first user to a second user, receiving a location of the first user, determining an urgency of the electronic communication based at least in part on the location of the user, and providing an indication of the urgency as determined for presentation to the second user.

Abstract: In particular embodiments, one or more computer systems of a social-networking system provide social content for display in a mobile application running on a mobile device of a user of the social-networking system. The mobile application is configured to display the social content and an interface for selecting media content to view on a display device. The social content is from a social graph of the social-networking system. The social graph includes nodes and edges connecting the nodes. The nodes include user nodes that are each associated with a particular user of the social-networking system. The one or more computer systems of the social-networking system receive an indication from the mobile application that an option to view particular media content has been selected and provide one or more instructions to display the selected particular media content on the display device.

Abstract: A method that adds material selectively to a lens substrate and is used to produce a customized eyewear lens with optical power that is discernibly different from the optical power of the lens substrate. The method involves obtaining the lens substrate, calculating and generating an added material design to convert the lens substrate's optical power to a desired optical power for the customized eyewear lens, contacting the lens substrate with a bulk source of flowable radiation-polymerizable material, and irradiating the material with radiation that is controlled for wavelength range, energy and spatial distribution to polymerize the radiation-polymerizable material only in a selected area according to the added material design. The method does not require the use of external shaping structures to form the customized lens on the lens substrate, and the added material is integrally bonded to the substrate.

Abstract: In one embodiment, a method includes receiving sensor data, while a mobile electronic device associated with a member of a social-networking system is in a first operation state, from one or more sensors of the mobile electronic device and obtaining characteristic information maintained by the social-networking system, the social-networking system being remote from the mobile electronic device. The method also includes verifying that a current user of the mobile electronic device is the member by comparing the sensor data to the characteristic information. The method also includes, in response to the verifying, transitioning from the first operation state to a second operation state.

Abstract: In particular embodiments, one or more computer systems of a social-networking system determine information associated with a product displayed on a display device and access a database of known products. The one or more computer systems of the social-networking system determine, by comparing the database of known products with the determined information associated with the product, an identity of the product displayed on the display device. The one or more computer systems of the social-networking system provide one or more instructions to display media content related to the identified product.

Abstract: In one embodiment, while a mobile electronic device is in a first operation state, it receives sensor data from one or more sensors of the mobile electronic device. The mobile electronic device analyzes the sensor data to estimate a current intention of a user with respect to the mobile electronic device; and transition from the first operation state to a second operation state based on the current intention of the user with respect to the mobile electronic device.

Abstract: In one embodiment, device status information is received from a mobile device of a first user. The device status information may include: information related to power for the device, information related to network connectivity of the device, or a notification mode of the device. Outgoing messages may be identified to be sent to the first user. A value may be computed for each of the outgoing messages. The computed value may be based on an affinity score determined with respect to an originator of the message and the first user. Based on the computed value, at least one of the outgoing messages may be selected for placement into an outgoing message queue. Upon the detection of a triggering condition, the selected messages may be sent to the mobile device. The triggering condition may be based on the device status information and the respective values of the outgoing messages.

Abstract: In particular embodiments, one or more computer systems of a social-networking system determine available media content from one or more content sources and query a social graph of a social-networking system for social content associated with a user of the social-networking system. The social graph includes nodes and edges connecting the nodes. The nodes include user nodes that are each associated with a particular user of the social-networking system. The one or more computer systems of the social-networking system determine, using the social content and the available media content, a plurality of social coefficients for the user, determine, based on the determined social coefficients, recommended media content for the user, and provide the recommended media content for display in a programming guide on a display device.

Abstract: In one embodiment, a method comprising by one or more computing devices, transmitting, from a first mobile device, a first message that includes a first user identifier corresponding to a first user of the first mobile device, wherein the first user identifier corresponds to a user account of the first user in a social-networking system, receiving, at the first mobile device, one or more second messages that includes a second user identifier corresponding to a second mobile device within a direct radio connectivity of the first mobile device, wherein the second user identifier corresponds to a respective user account of a second user in the social-networking system, and storing, at the first mobile device, information received in the second message for access by one or more applications hosted on the first mobile device.

Abstract: In one embodiment, a computing system receives a first set of location updates sent by a first user. Each location update corresponds to a user visit to a particular place, and each location update is determined by a mobile client device of the corresponding user via a first or a second location method. The computing system receives a second set of location updates sent by a second user, sent via only the first location method. A place-visit factor for the second user is calculated based on the total number of unique places visited by the second user within a particular period of time, a first number of places visited by the first user determined from location updates sent via the first location method, and a second number of places visited by the first user determined from location updates sent via the second location method.

Abstract: In one embodiment, a computer system receives an indication of a power state of a client device, identifies messages to be sent to the client device, determines a transmit cost and a value of each of the messages, and stores at least one of the messages in a queue based on the transmit cost and value of the message.

Abstract: The present application relates to compounds of formula (I), (Ia), or (Ib) and their pharmaceutical compositions/preparations. This application further relates to methods of treating or preventing A?-related pathologies such as Down's syndrome, ?-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI (“mild cognitive impairment”), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia, including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease.

Abstract: In particular embodiments, one or more computer systems of a social-networking system identify a user viewing video content on a first display device, identify the video content being viewed on the first display device by the user, and determine a second display device associated with the identified user. The one or more computer systems of the social-networking system determine an action related to the video content being viewed by the user on the first display device and provide one or more instructions to the determined second display device to display a call-to-action associated with the determined action.

Abstract: In one embodiment, device status information is received from a mobile device of a first user. The device status information may include: information related to power for the device, information related to network connectivity of the device, or a notification mode of the device. Outgoing messages may be identified to be sent to the first user. A value may be computed for each of the outgoing messages. The computed value may be based on an affinity score determined with respect to an originator of the message and the first user. Based on the computed value, at least one of the outgoing messages may be selected for placement into an outgoing message queue. Upon the detection of a triggering condition, the selected messages may be sent to the mobile device. The triggering condition may be based on the device status information and the respective values of the outgoing messages.

Abstract: In one embodiment, a method includes accessing at least two determinations of the location of a mobile computing device, with each determined location having been determined without reference to explicit location information manually input by a user of the mobile computing device. At least one first determined location is compared with at least one second determined location, with comparisons being made between location determinations made based on different location determination input. A functionality associated with the mobile computing device is allowed if the first determined location corresponds to at least one of the second determined locations.

Abstract: A collapsible cart (10) having a frame (12), a tongue assembly (22), at least one axle (14) and a base (34). The tongue assembly (22) may be configured to releasably couple the frame (12) to a receiver hitch. The axle (14) may be operatively connected to at least one wheel assembly (16). The axle (14) may also be operatively connected and rotatable relative to the frame (12). The base (34) may be operatively connected to the frame (12). The collapsible cart (10) may have at least one retaining wall (24, 26, 28, 30, 32), and/or wheel bracket (17).