Abstract: In one aspect, the subject invention is directed to a method of preparing a combinatorial drug delivery device based on a predetermined selection of drug components. The method includes: preparing a plurality of containers, each accommodating one of the selected drug components; coupling the containers to a common outlet so that the drug components may be extracted from the containers and dispensed through the common outlet; and, applying negative pressure to extract the drug components from the containers and urge the drug components towards the common outlet.

Abstract: In one aspect, a system is provided of verifying the accuracy of a plurality of serially-connected drug modules of a combinatorial drug delivery device, each of the drug modules including a drug reservoir, the system including: a machine-readable code located on each of the drug modules; application software configured to generate an activation code based on the machine-readable codes and the sequence of the machine-readable codes; a flow controller on the drug delivery device which is selectively actuatable to a use state to permit flow of drug from the drug delivery device; and, a control unit on the drug delivery device having a computing processing unit configured to compare the activation code with an authentication code, and, wherein, if the authentication code matches the activation code, the computing processing unit causes actuation of the flow controller to permit flow of the drug from the drug delivery device.

Abstract: In one aspect, a combinatorial drug delivery device is provided for delivering a predetermined selection of drug components. The device includes a plurality of modules, each including: a body having an interior volume; a spike plate movably disposed in the interior volume, the spike plate having a protruding cannula and first and second ports. The device also includes a base tray which includes: a framework defining a plurality of wells, each of the wells formed to insertingly receive one of the modules; for each of the wells, first and second inlet ports formed to interface with the first and second ports of the module being received in the respective well; passageways to connect certain wells with adjacent wells to permit fluid flow therebetween. For each of the wells, the spike plate of the respective module being maintained in a stationary position with the module being inserted into the well.

Abstract: In one aspect, a system is provided of verifying the accuracy of a plurality of serially-connected drug modules of a combinatorial drug delivery device, each of the drug modules including a drug reservoir, the system including: a machine-readable code located on each of the drug modules; application software configured to generate an activation code based on the machine-readable codes and the sequence of the machine-readable codes; a flow controller on the drug delivery device which is selectively actuatable to a use state to permit flow of drug from the drug delivery device; and, a control unit on the drug delivery device having a computing processing unit configured to compare the activation code with an authentication code, and, wherein, if the authentication code matches the activation code, the computing processing unit causes actuation of the flow controller to permit flow of the drug from the drug delivery device.

Abstract: In one aspect, a combinatorial drug delivery device is provided for delivering a predetermined selection of drug components. The device includes a plurality of modules, each including: a body having an interior volume; a spike plate movably disposed in the interior volume, the spike plate having a protruding cannula and first and second ports. The device also includes a base tray which includes: a framework defining a plurality of wells, each of the wells formed to insertingly receive one of the modules; for each of the wells, first and second inlet ports formed to interface with the first and second ports of the module being received in the respective well; passageways to connect certain wells with adjacent wells to permit fluid flow therebetween. For each of the wells, the spike plate of the respective module being maintained in a stationary position with the module being inserted into the well.

Abstract: A locking washer for use with a screw-threaded fastener (71), said locking device comprising a first disc-like body (12) comprising an annular portion (13) with at least one aperture (15) therein and a central through-hole (14) e.g. a washer having notches (15) open to the outer or inner periphery and at least one further body (25) held in said one aperture (15). The further body may be a shim (22) also having a central hole (24) and at least one tab (25) extending through the notch (15) and has an end portion which juts above adjacent surface of the washer to engage a surface on the fastener when, on tightening of the fastener, deflects within the void of its aperture under tightening of the engaging surface such that under any tendency to loosen, the tab jams against the opposing surfaces and resist loosening of the fastener.

Abstract: The present invention relates to a locking device 1 having a deadbolt 104 within a casing 102, which deadbolt 104 is movable between an advanced position wherein it protrudes from a front face of the casing 102 and a retreated position, wherein it is retracted into the casing 102. The locking device 1 comprises: a link plate 130 which moves the deadbolt 104 to the advanced position; a deadbolt blocking member 110 which is moveable between a blocking position blocking the deadbolt 104 in the advanced position and an unblocking position to allow the deadbolt 104 to move to the retreated position; an electrically driven actuator unit 120 which moves the deadbolt blocking member 110 between the blocking position and the unblocking position; and a control circuit configured to control the electrically driven actuator unit 120 so that once the deadbolt 104 is moved to the advanced position, the deadbolt blocking member 110 is moved to the blocking position by actuation of the electrically driven actuator unit 120.

Abstract: A locking device (11), e.g. a lock washer, for use with a screw threaded fastener (71), said locking device comprising at least a first disc-like body (12) comprising an annular portion (13) with at least one aperture (15) therein and a central through-hole (14) e.g. a washer having notches (15) open to the outer periphery and at least one further body (25) held in said one aperture (15). The further body may be shim (22) also having a central hole (24) and at least one tab (25) which extends through the notch (15) and has an end portion which juts above adjacent surface of the washer to engage an adjacent surface on the fastener when compressed, on tightening of the fastener deflects within the void of the aperture in which it is located under the influence of the tightening of the engaging surface such that under any tendency to loosen, the tab jams against the opposing surfaces and resist loosening of the fastener.

Abstract: In one aspect, a combinatorial drug delivery device is provided for delivering a predetermined selection of drug components. The device includes a plurality of modules, each including: a body having an interior volume; a spike plate movably disposed in the interior volume, the spike plate having a protruding cannula and first and second ports. The device also includes a base tray which includes: a framework defining a plurality of wells, each of the wells formed to insertingly receive one of the modules; for each of the wells, first and second inlet ports formed to interface with the first and second ports of the module being received in the respective well; passageways to connect certain wells with adjacent wells to permit fluid flow therebetween. For each of the wells, the spike plate of the respective module being maintained in a stationary position with the module being inserted into the well.

Abstract: In one aspect, a drug delivery device is provided for delivering drug from a plurality of drug cartridges. The drug delivery device includes: a cylindrical cassette configured to accommodate the plurality of drug cartridges; a reversibly advanceable plunger; and, an indexer for incrementally rotating the cassette to align the plurality of drug cartridges individually with the plunger. The indexer includes first and second shafts with cooperating elements which cause incremental rotation of the first shaft, relative to the second shaft, upon the second shaft engaging the first shaft.

Abstract: An assembly for an autoinjector device, the assembly including a syringe support for supporting a syringe by limiting forward axial movement of the syringe relative to the syringe support, and a guard element attachable to the syringe support by an attachment so that the guard element is axially restrained both axially forwardly and axially rearwardly relative to the syringe support by the attachment. Forwardly directed axial loads received by the guard element are transmitted to the syringe support via the attachment.

Abstract: In one aspect, a combinatorial drug delivery device is provided herein including: a plurality of serially connectable modules, each including at least one drug component; and, a master controller having a computing processing unit. Each of the modules includes: a non-transitory memory having stored therein an address and an alphanumeric code representative of the at least one drug component contained in the corresponding drug module; a secondary controller operatively linked to the memory of the corresponding module; and, at least one communication bus connectable in series with the communication buses of the modules serially connected with the corresponding module. The master controller is configured to serially interrogate the secondary controllers over the serially-connected communication buses, using the addresses, to request the codes of the corresponding modules.

Abstract: A combinatorial drug delivery device is provided herein including: a plurality of serially connectable modules, each including at least one drug component; and, a master controller. Each of the modules includes: a power line; a ground line; a multiplexer having a plurality of identified input channels, at least a subset of the input channels being selectively connected to one of the power and ground lines; a first digital logic line configured to select the input channels; a voltage reference line having a first resistor in line with an output of the multiplexer; a branch line connected to the voltage reference line having a normally closed switch thereon to connect the branch line to the ground line, the switch being opened with connection to a further module. The master controller selects, in sequence, the same identified input channels across all of the modules with measuring a reference voltage thereacross.

Abstract: Various embodiments are provided herein for checking proper inclusion and sequencing of drug modules in a combinatorial drug delivery device.

Abstract: Various embodiments are disclosed herein related to fluidic connections for modules useable in combinatorial drug delivery devices. The fluidic connections allow for variable flow paths to be defined for serially-connected, and base-tray mounted, modules.

Abstract: In one aspect, a system is provided of verifying the accuracy of a plurality of serially-connected drug modules of a combinatorial drug delivery device, each of the drug modules including a drug reservoir, the system including: a machine-readable code located on each of the drug modules; application software configured to generate an activation code based on the machine-readable codes and the sequence of the machine-readable codes; a flow controller on the drug delivery device which is selectively actuatable to a use state to permit flow of drug from the drug delivery device; and, a control unit on the drug delivery device having a computing processing unit configured to compare the activation code with an authentication code, and, wherein, if the authentication code matches the activation code, the computing processing unit causes actuation of the flow controller to permit flow of the drug from the drug delivery device.

Abstract: A valving arrangement is provided herein for regulating fluidics of modules usable in a combinatorial drug delivery device. The valving includes a slidable piston valve, adjustable to selectively seal an outlet path from a drug vial and a sealing port, in parallel to a vent, for selectively sealing an inlet path to the drug vial. Advantageously, the subject invention allows for applied negative pressure to adjust the valving to allow flow between serially-connected modules forming a drug delivery device.

Abstract: In one aspect, a combinatorial drug delivery device is provided for delivering a predetermined selection of drug components. The device includes a plurality of modules, each including: a body having an interior volume; a spike plate movably disposed in the interior volume, the spike plate having a protruding cannula and first and second ports. The device also includes a base tray which includes: a framework defining a plurality of wells, each of the wells formed to insertingly receive one of the modules; for each of the wells, first and second inlet ports formed to interface with the first and second ports of the module being received in the respective well; passageways to connect certain wells with adjacent wells to permit fluid flow therebetween. For each of the wells, the spike plate of the respective module being maintained in a stationary position with the module being inserted into the well.

Abstract: A locking device (11), e.g. a lock washer, for use with a screw threaded fastener (71), said locking device comprising at least a first disc-like body (12) comprising an annular portion (13) with at least one aperture (15) therein and a central through-hole (14) e.g. a washer having notches (15) open to the outer periphery and at least one further body (25) held in said one aperture (15). The further body may be shim (22) also having a central hole (24) and at least one tab (25) which extends through the notch (15) and has an end portion which juts above adjacent surface of the washer to engage an adjacent surface on the fastener when compressed, on tightening of the fastener deflects within the void of the aperture in which it is located under the influence of the tightening of the engaging surface such that under any tendency to loosen, the tab jams against the opposing surfaces and resist loosening of the fastener.

Abstract: In one aspect, the subject invention is directed to a method of preparing a combinatorial drug delivery device based on a predetermined selection of drug components. The method includes: preparing a plurality of containers, each accommodating one of the selected drug components; coupling the containers to a common outlet so that the drug components may be extracted from the containers and dispensed through the common outlet; and, applying negative pressure to extract the drug components from the containers and urge the drug components towards the common outlet.