Abstract: Disclosed systems and methods obtain a graph of a polymer comprising nodes and edges, the nodes representing polymer atoms, the edges encoding distances and relative orientations between corresponding pairs of nodes and whether pairs of nodes are covalently bound. Each subgraph in a plurality of first partial-context subgraphs of the graph is sequentially inputted into a first model to calculate first side chain dihedral angles for polymer residues. This updates the graph through first side chain dihedral angles. Each second subgraph in a plurality of second partial-context subgraphs of the updated graph is inputted into a second model, thereby obtaining calculated second side chain dihedral angles for polymer residues that serve to update the graph through second side chain dihedral angles. The graph is again updated with updated side chain dihedral angle values obtained by sequentially inputting full-context subgraphs, each such subgraph representing a different residue, into a full-context model.

Abstract: A system and method for managing telephone communications. An originating telephone carrier originates telephone calls by users and conveys the telephone calls to an internet protocol network provider for termination. The internet protocol network provider conveys the received telephone calls to a service platform comprising a softswitch for termination. The service platform applies one or more services to received telephone calls and routes the terminated telephone calls to a final carrier. A final carrier receives the telephone calls from the service platform and terminates telephone calls.

Abstract: A high-sensitivity chemiluminescent ELISA-based prion detection method is provided, the method comprising an ELISA plate coated with monoclonal antibody for the capture of PrPsc protein and treated with an optimized blocking reagent, and a set of labeling and detection reagents. The digestion cocktail is preferably a unique combination of proteolytic, lipolytic and nuclease enzymes for the liberation of the prion PrPsc antigen. The ELISA plate is preferably a multi-well, high-protein binding, microtiter plate coated with an anti-prion monoclonal antibody, used to capture the PrPsc antigen. The blocking agent is an optimized protein and buffer solution. The detection antibody is preferably a biotinylated monoclonal antibody. The chemiluminescent conjugate is preferably a conjugate of streptavidin and alkaline phosphatase enzyme. The final component is preferably an optimized chemiluminescent substrate for maximum sensitivity.