Abstract: The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicable for use in health, skin, hair, oral, beauty, and personal care applications. In particular, the present invention relates to compounds having the structure: and the tautomers, acceptable salts, and biohydrolyzable amides, esters, and imides thereof, wherein A, Q, n, P, L1, L2, L3, L4, Z, X, B1, and B2 are defined herein.

Abstract: Aqueous liquid detergent compositions are described which comprise a proteolytic enzyme wherein the proteolytic activity is reversibly inhibited by a peptide protease inhibitor.

Abstract: Aqueous liquid detergent compositions are described which comprising a proteolytic enzyme wherein the proteolytic activity is reversibly inhibited by a protease inhibitor selected from the group consisting of aldehydes and trifluoromethyl ketones.

Abstract: Aqueous liquid detergent compositions are described which comprise a proteolytic enzyme wherein the proteolytic activity is reversibly inhibited by a peptide protease inhibitor selected from the group consisting of aldehydes and trifluoromethyl ketones.

Abstract: The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to Formula (I) ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable alkoxyamide, ester, acyloxyamide, or imide thereof. Also disclosed are compounds, pharmaceutical compositions and methods of treating diseases characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

Abstract: The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicable for use in health, skin, hair, oral, beauty, and personal care applications.In particular, the present invention relates to compounds having the structure: ##STR1## and the tautomers, acceptable salts, and biohydrolyzable amides, esters, and imides thereof, wherein A, Q, n, P, L.sub.1, L.sub.2, L.sub.3, L.sub.4, Z, X, B.sub.1, and B.sub.2 are defined herein.

Abstract: Aqueous liquid detergent compositions are described which comprise a proteolytic enzyme wherein the proteolytic activity is reversibly inhibited by a peptide trifluoromethyl ketone.

Abstract: The invention relates to a detergent composition which is a liquid detergent composition which comprises a surfactant, a proteolytic enzyme, and an enzyme inhibitor which is a peptide aldehyde. Said peptide aldehyde inhibitor contain 4 or 5 amino acids. Said peptide aldehydes are used to enhance the stability of proteolytic enzymes in liquid detergent environments.

Abstract: The subject invention involves anti-inflammatory compounds having the following structure: ##STR1## wherein: a) --X is cyclic alkyl, having from 4 to 15 carbon atoms; branched alkyl, having from 6 to 15 carbon atoms; or aryl having from 6 to 15 carbon atoms;(b) n is an integer from 0 to 2;(c) --V-- is --OC(O)--, --N(Q)C(O)--, --N(Q)C(S)--, --C(O)--, --SO2-- or --P(O)(OH)--;(d) --Q is hydrogen; or straight or branched chain alkyl, saturated or unsaturated with 1 or 2 double bonds, having from 1 to 6 carbon atoms; or --Q and --X are covalently linked forming a cyclic moiety which includes the nitrogen to which --Q is bonded and from 5 to 20 carbon atoms;(e) Z is --O-- or --NH--; when V is --OC(O)--, --Z-- is --NH--;(f) --R1 is a hydrophobic moiety;(g) --R2 is a hydrophobic moiety;(h) --R3 is --(CH2)m--A--NH2 or --(CH2)m--A--B--C(NH2).dbd.