Patents by Inventor John Mekalanos

John Mekalanos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CGAS/DNCV-LIKE NUCLEOTIDYLTRANSFERASES AND USES THEREOF
    Publication number: 20220127586
    Abstract: The present invention is based, in part, on the discovery and characterization of the CD-NTase family of proteins, as well as compositions comprising CD-NTases, methods of producing nucleotide-based second messengers using such polypeptides, and methods of screening for modulators of the structure, expression, and/or activity of such polypeptides.
    Type: Application
    Filed: September 4, 2019
    Publication date: April 28, 2022
    Inventors: Aaron Whiteley, Philip J. Kranzusch, John Mekalanos, James Eaglesham
  • METHODS AND COMPOSITIONS FOR AQUACULTURE
    Publication number: 20210084905
    Abstract: In certain aspects, disclosed herein are novel compositions and methods related to aquaculture.
    Type: Application
    Filed: February 19, 2019
    Publication date: March 25, 2021
    Inventors: John Mekalanos, William Robbins
  • METHODS FOR DISPLAYING POLYPEPTIDES AND USES THEREOF
    Publication number: 20180147273
    Abstract: Provided herein are methods and compositions for displaying a polypeptide on a tubular structure and uses of such displayed polypeptides in the production of antibodies or vaccines.
    Type: Application
    Filed: December 4, 2017
    Publication date: May 31, 2018
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: John Mekalanos, Marek Basler
  • Methods for displaying polypeptides and uses thereof
    Patent number: 9833503
    Abstract: Provided herein are methods and compositions for displaying a polypeptide on a tubular structure and uses of such displayed polypeptides in the production of antibodies or vaccines.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: December 5, 2017
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: John Mekalanos, Marek Basler
  • METHODS FOR DISPLAYING POLYPEPTIDES AND USES THEREOF
    Publication number: 20150132334
    Abstract: Provided herein are methods and compositions for displaying a polypeptide on a tubular structure and uses of such displayed polypeptides in the production of antibodies or vaccines.
    Type: Application
    Filed: February 22, 2013
    Publication date: May 14, 2015
    Inventors: John Mekalanos, Marek Basler
  • Methods and Compositions for Treating and Preventing Bacterial Infections
    Publication number: 20090214531
    Abstract: The invention features methods and compositions for treating or preventing Gram-negative bacterial infections.
    Type: Application
    Filed: January 29, 2007
    Publication date: August 27, 2009
    Inventors: John Mekalanos, Stefan Pukatzki, Joseph Mougous
  • Protein matrix vaccines and methods of making and administering such vaccines
    Publication number: 20080095803
    Abstract: The invention relates to vaccine compositions having a carrier protein and an antigen of interest entrapped in a complex, methods of making such vaccines, and methods of vaccine administration.
    Type: Application
    Filed: August 7, 2007
    Publication date: April 24, 2008
    Applicant: President and Fellows of Harvard College
    Inventor: John Mekalanos
  • Diphtheria toxin vaccines
    Patent number: 5601827
    Abstract: A DNA encoding an immunologically cross-reactive form of diphtheria toxin Fragment A, wherein the codons corresponding to Val-147 and Glu-148 of naturally-occurring diphtheria toxin are deleted from the DNA.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: February 11, 1997
    Assignee: President and Fellows of Harvard College
    Inventors: R. John Collier, Kevin Killeen, John Mekalanos