Abstract: Systems and methods are disclosed which relate to improving synchronization of clocks between a sender and a receiver communicating via an asynchronous serial interface. In a ring topology, a master device is connected to a plurality of slaves communicating using a bi-frequency encoded bit stream. A host device communicates with the master device using a non-return-to-zero data encoding. Each slave receives data from the master and sends it to the next slave in the ring unaltered unless the master indicates a requirement for a particular data, and transmits placeholder bits with a value of 0 around the ring. A particular slave can “fill-in” the placeholder bits with the information to be sent back to the master by inverting the placeholder bit. Clock synchronization between a receiving device and a transmitting device is improved using a fractional rate multiplier to generate a data sampling clock from a system clock.