Patents by Inventor John Michael Thomas
John Michael Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11952305Abstract: In some embodiments, a method for processing an optical fiber includes: drawing an optical fiber through a draw furnace, conveying the optical fiber through a flame reheating device downstream from the draw furnace, wherein the flame reheating device comprises one or more burners each comprising: a body having a top surface and an opposing bottom surface, an opening within the body extending from the top surface through the body to the bottom surface, wherein the optical fiber passes through the opening, and one or more gas outlets within the body; and igniting a flammable gas provided by the one or more gas outlets to form a flame encircling the optical fiber passing through the opening, wherein the flame heats the optical fiber by at least 100 degrees Celsius at a heating rate exceeding 10,000 degrees Celsius/second.Type: GrantFiled: September 30, 2021Date of Patent: April 9, 2024Assignee: CORNING INCORPORATEDInventors: Ravindra Kumar Akarapu, Joel Patrick Carberry, David Alan Deneka, Steven Akin Dunwoody, Kenneth Edward Hrdina, John Michael Jewell, Yuanjie Jiang, Nikolaos Pantelis Kladias, Ming-Jun Li, Barada Kanta Nayak, Dale Robert Powers, Chunfeng Zhou, Vincent Matteo Tagliamonti, Christopher Scott Thomas
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Publication number: 20220362611Abstract: A handheld exercise device is an apparatus that enables the user to exercise the upper body due to the load applied on the user's arms from the centripetal force created by moving the apparatus using one or two hands. To do so, the apparatus may include an O-ring housing, a crossbar, a bearing assembly, and a control system. The O-ring housing is designed to retain the bearing assembly in such a way that the user can move the bearing assembly in a circular motion within the O-ring housing. The crossbar facilitates the handling of the O-ring housing with one or two hands in order for the user to move the bearing assembly in a circular motion within the O-ring housing. The control system helps the user keep track of the movement of the bearing assembly so that the user can measure the exercise progress while handling the apparatus.Type: ApplicationFiled: May 13, 2022Publication date: November 17, 2022Inventor: John Michael Thomas
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Publication number: 20220251076Abstract: The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.Type: ApplicationFiled: April 14, 2022Publication date: August 11, 2022Inventors: Mark Jon Olsen, John-Michael Thomas
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Publication number: 20210032233Abstract: The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.Type: ApplicationFiled: September 23, 2020Publication date: February 4, 2021Inventors: Mark Jon Olsen, John-Michael Thomas
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Publication number: 20200361925Abstract: The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.Type: ApplicationFiled: June 2, 2020Publication date: November 19, 2020Inventors: Jack R. Wands, Suzanne De La Monte, Arihiro Aihara, Mark Jon Olsen, John-Michael Thomas
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Patent number: 10787445Abstract: The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.Type: GrantFiled: June 12, 2019Date of Patent: September 29, 2020Assignee: Midwestern UniversityInventors: Mark Jon Olsen, John-Michael Thomas
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Patent number: 10710995Abstract: The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.Type: GrantFiled: September 26, 2017Date of Patent: July 14, 2020Assignees: Rhode Island Hospital, Midwestern UniversityInventors: Jack R. Wands, Suzanne De La Monte, Arihiro Aihara, Mark Jon Olsen, John-Michael Thomas
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Publication number: 20190300519Abstract: The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.Type: ApplicationFiled: June 12, 2019Publication date: October 3, 2019Inventors: Mark Jon Olsen, John Michael Thomas
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Patent number: 10351555Abstract: The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.Type: GrantFiled: September 14, 2018Date of Patent: July 16, 2019Assignee: Midwestern UniversityInventors: Mark Jon Olsen, John Michael Thomas
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Publication number: 20190002453Abstract: The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.Type: ApplicationFiled: September 14, 2018Publication date: January 3, 2019Inventors: Mark Jon Olsen, John Michael Thomas
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Patent number: 10106532Abstract: The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.Type: GrantFiled: July 17, 2017Date of Patent: October 23, 2018Assignee: Midwestern UniversityInventors: Mark Jon Olsen, John Michael Thomas
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Publication number: 20180237427Abstract: The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.Type: ApplicationFiled: September 26, 2017Publication date: August 23, 2018Inventors: Jack R. Wands, Suzanne De La Monte, Arihiro Aihara, Mark Jon Olsen, John-Michael Thomas
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Publication number: 20180009798Abstract: The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.Type: ApplicationFiled: July 17, 2017Publication date: January 11, 2018Inventors: Mark Jon Olsen, John Michael Thomas
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Patent number: 9771356Abstract: The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydroxylase (e.g., Asparatyl (asparaginyl) ?-hydroxylase (ASPH)), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.Type: GrantFiled: September 20, 2013Date of Patent: September 26, 2017Assignees: Rhode Island Hospital, Midwestern UniversityInventors: Jack R. Wands, Suzanne De La Monte, Arihiro Aihara, Mark Jon Olsen, John-Michael Thomas
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Publication number: 20150210677Abstract: The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydroxylase (e.g., Asparatyl (asparaginyl) ?-hydroxylase (ASPH)), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.Type: ApplicationFiled: September 20, 2013Publication date: July 30, 2015Inventors: Jack R. Wands, Suzanne de la Monte, Arihiro Aihara, Mark Jon Olsen, John-Michael Thomas
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Patent number: 8540458Abstract: A center hole ram can have a barrel, and a piston that is moveable relative to the barrel. The piston can define an axial hole that extends through the piston. A gripping assembly can be attached to the ram. The gripping assembly can be configured to grip a cable and pull the cable through the axial hole in response to multiple actuating strokes of the ram. Also, a bursting head can be attached to a cable. The cable can be pulled through a tunnel (such as an existing pipe) and through a piston of a ram. Pulling the cable can result in the cable pulling the bursting head through the tunnel toward the ram. Also, pulling the cable can include gripping the cable with a gripping assembly attached to the ram, and actuating the ram.Type: GrantFiled: June 14, 2011Date of Patent: September 24, 2013Assignee: Roodle, Inc.Inventors: Rod Herrick, John Michael Thomas
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Publication number: 20120321391Abstract: A center hole ram can have a barrel, and a piston that is moveable relative to the barrel. The piston can define an axial hole that extends through the piston. A gripping assembly can be attached to the ram. The gripping assembly can be configured to grip a cable and pull the cable through the axial hole in response to multiple actuating strokes of the ram. Also, a bursting head can be attached to a cable. The cable can be pulled through a tunnel (such as an existing pipe) and through a piston of a ram. Pulling the cable can result in the cable pulling the bursting head through the tunnel toward the ram. Also, pulling the cable can include gripping the cable with a gripping assembly attached to the ram, and actuating the ram.Type: ApplicationFiled: June 14, 2011Publication date: December 20, 2012Applicant: RODDIE, INC.Inventors: Rod Herrick, John Michael Thomas