Patents by Inventor John Middleton

John Middleton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Packaged presliced ready-to-eat meat products and methods thereof
    Patent number: 12642279
    Abstract: Sliced ready-to-eat meat are provided by slicing ready-to-eat meat, disposing the meat into a flexible pouch with a modified atmosphere, and sealing the flexible pouch containing the meat. The flexible pouch is formed from material having: i) a thickness of from about 0.2 mils to about 2 mils; ii) an MVTR of about 1.2 g/100 in2/24 Hrs @ 100° F., 90% RH, 1 atm or less; iii) an 02 Gas Transmission Rate of about 0.8 cc/100 sqin/day or less at 1 atmosphere, 0% relative humidity and 73° F. or less; and iv) a clarity of about 80% or greater.
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: June 2, 2026
    Assignee: Cargill, Incorporated
    Inventors: Garret Dietz, John Middleton, Jonathan Patrick Paul
  • POLYMERIC LEUPROLIDE ACETATE FORMULATIONS
    Publication number: 20260069531
    Abstract: Liquid-liquid polymer leuprolide acetate (LA) formulations comprising a biodegradable polymer and biocompatible solvent, and methods of using the formulations.
    Type: Application
    Filed: October 20, 2025
    Publication date: March 12, 2026
    Inventors: Dileep Janagam, David Dummer, Travis Kauffman, John Middleton, Amy Van Hove, Nicole Marquardt, Nicholas DeWeerd, Erik Cullen Johnson
  • LEUPROLIDE ACETATE COMPOSITIONS AND METHODS OF USING THE SAME TO TREAT BREAST CANCER
    Publication number: 20260027176
    Abstract: Compositions and methods for suppressing ovarian function in subjects with hormone receptor-positive breast cancer.
    Type: Application
    Filed: September 30, 2025
    Publication date: January 29, 2026
    Inventors: John Middleton, Avinash Nangia, John Arthur McLane, Terri L. Morton
  • Leuprolide acetate compositions and methods of using the same to treat breast cancer
    Patent number: 12453754
    Abstract: Compositions and methods for suppressing ovarian function in subjects with hormone receptor-positive breast cancer.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: October 28, 2025
    Assignee: Tolmar International Limited
    Inventors: John Middleton, Avinash Nangia, John Arthur Mclane, Terri L. Morton
  • Liquid polymer delivery system for extended administration of drugs
    Patent number: 12447158
    Abstract: Liquid polymer pharmaceutical compositions with a biodegradable liquid polyester that has a carboxylic acid end group, a biocompatible solvent, and an active pharmaceutical agent are useful for administration into the body to provide extended long term release of the drug.
    Type: Grant
    Filed: August 9, 2023
    Date of Patent: October 21, 2025
    Assignee: Tolmar International Limited
    Inventors: John Milton Downing, Vipin Saxena, John Middleton
  • LIQUID POLYMER DELIVERY SYSTEM FOR EXTENDED ADMINISTRATION OF DRUGS
    Publication number: 20240066039
    Abstract: Liquid polymer pharmaceutical compositions with a biodegradable liquid polyester that has a carboxylic acid end group, a biocompatible solvent, and an active pharmaceutical agent are useful for administration into the body to provide extended long term release of the drug.
    Type: Application
    Filed: August 9, 2023
    Publication date: February 29, 2024
    Inventors: John Milton Downing, Vipin Saxena, John Middleton
  • PACKAGED PRESLICED READY-TO-EAT MEAT PRODUCTS AND METHODS THEREOF
    Publication number: 20230337690
    Abstract: Sliced ready-to-eat meat are provided by slicing ready-to-eat meat, disposing the meat into a flexible pouch with a modified atmosphere, and sealing the flexible pouch containing the meat. The flexible pouch is formed from material having: i) a thickness of from about 0.2 mils to about 2 mils; ii) an MVTR of about 1.2 g/100 in2/24 Hrs @ 100° F., 90% RH, 1 atm or less; iii) an 02 Gas Transmission Rate of about 0.8 cc/100 sqin/day or less at 1 atmosphere, 0% relative humidity and 73° F. or less; and iv) a clarity of about 80% or greater.
    Type: Application
    Filed: January 27, 2021
    Publication date: October 26, 2023
    Applicant: Cargill, Incorporated
    Inventors: Garret DIETZ, John MIDDLETON, Jonathan Patrick PAUL
  • Liquid polymer delivery system for extended administration of drugs
    Patent number: 11779589
    Abstract: Liquid polymer pharmaceutical compositions with a biodegradable liquid polyester that has a carboxylic acid end group, a biocompatible solvent, and an active pharmaceutical agent are useful for administration into the body to provide extended long term release of the drug.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: October 10, 2023
    Assignee: Tolmar International Limited
    Inventors: John Milton Downing, Vipin Saxena, John Middleton
  • Low-burst polymers and methods to produce polymer
    Patent number: 11717572
    Abstract: A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: August 8, 2023
    Assignee: Tolmar, Inc.
    Inventors: Eric Dadey, John Middleton, Richard L. Norton
  • LEUPROLIDE ACETATE COMPOSITIONS AND METHODS OF USING THE SAME TO TREAT BREAST CANCER
    Publication number: 20220265760
    Abstract: Compositions and methods for suppressing ovarian function in subjects with hormone receptor-positive breast cancer.
    Type: Application
    Filed: May 26, 2020
    Publication date: August 25, 2022
    Inventors: John MIDDLETON, Avinash NANGIA, John Arthur MCLANE, Terri L. MORTON
  • LOW-BURST POLYMERS AND METHODS TO PRODUCE POLYMER
    Publication number: 20220202941
    Abstract: A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.
    Type: Application
    Filed: September 16, 2021
    Publication date: June 30, 2022
    Inventors: Eric Dadey, John Middleton, Richard L. Norton
  • Low-burst polymers and methods to produce polymer
    Patent number: 11147880
    Abstract: A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: October 19, 2021
    Assignee: Tolmar Therapeutics, Inc.
    Inventors: Eric Dadey, John Middleton, Richard L. Norton
  • LIQUID POLYMER DELIVERY SYSTEM FOR EXTENDED ADMINISTRATION OF DRUGS
    Publication number: 20210060036
    Abstract: Liquid polymer pharmaceutical compositions with a biodegradable liquid polyester that has a carboxylic acid end group, a biocompatible solvent, and an active pharmaceutical agent are useful for administration into the body to provide extended long term release of the drug.
    Type: Application
    Filed: August 17, 2020
    Publication date: March 4, 2021
    Inventors: John Milton Downing, Vipin Saxena, John Middleton
  • Liquid polymer delivery system for extended administration of drugs
    Patent number: 10786515
    Abstract: Liquid polymer pharmaceutical compositions with a biodegradable liquid polyester that has a carboxylic acid end group, a biocompatible solvent, and an active pharmaceutical agent are useful for administration into the body to provide extended long term release of the drug.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: September 29, 2020
    Assignee: Tolmar International Limited
    Inventors: John Milton Downing, Vipin Saxena, John Middleton
  • LOW-BURST POLYMERS AND METHODS TO PRODUCE POLYMER
    Publication number: 20190209643
    Abstract: A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.
    Type: Application
    Filed: January 8, 2019
    Publication date: July 11, 2019
    Inventors: Eric Dadey, John Middleton, Richard L. Norton
  • Low-burst polymers and methods to produce polymer
    Patent number: 10206970
    Abstract: A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: February 19, 2019
    Assignee: Tolmar Therapeutics, Inc.
    Inventors: Eric Dadey, John Middleton, Richard L. Norton
  • LOW-BURST POLYMERS AND METHODS TO PRODUCE POLYMER
    Publication number: 20180311305
    Abstract: A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.
    Type: Application
    Filed: April 10, 2018
    Publication date: November 1, 2018
    Inventors: Eric Dadey, John Middleton, Richard L. Norton
  • LIQUID POLYMER DELIVERY SYSTEM FOR EXTENDED ADMINISTRATION OF DRUGS
    Publication number: 20180214459
    Abstract: Liquid polymer pharmaceutical compositions with a biodegradable liquid polyester that has a carboxylic acid end group, a biocompatible solvent, and an active pharmaceutical agent are useful for administration into the body to provide extended long term release of the drug.
    Type: Application
    Filed: August 3, 2016
    Publication date: August 2, 2018
    Inventors: John Milton DOWNING, Vipin SAXENA, John MIDDLETON
  • Low-burst polymers and methods to produce polymer
    Patent number: 9974824
    Abstract: A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: May 22, 2018
    Assignee: Tolmar Therapeutics, Inc.
    Inventors: Eric Dadey, John Middleton, Richard L. Norton
  • LOW-BURST POLYMERS AND METHODS TO PRODUCE POLYMER
    Publication number: 20170216395
    Abstract: A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.
    Type: Application
    Filed: April 18, 2017
    Publication date: August 3, 2017
    Inventors: Eric Dadey, John Middleton, Richard L. Norton