Abstract: The present invention relates to compounds of formula (I): wherein Q is O or S; R1 is a cyclic group substituted with at least one group X, wherein R1 may optionally be further substituted; X is any group comprising a carbonyl group; and R2 is a cyclic group substituted at the ?-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the dual action of NLRP3 inhibition and the stimulation of insulin secretion.

Abstract: A spray arm assembly for a dishwasher having a spray arm having a spray arm inlet, a bearing assembly having a bearing body defining a through passage with a bearing inlet and a bearing outlet fluidly coupled to the spray arm inlet; and a liquid supply conduit having a supply outlet fluidly coupled to the bearing inlet.

Abstract: The disclosed computer-implemented method may include applying, via a sound reproduction system, sound cancellation that reduces an amplitude of various sound signals. The method further includes identifying, among the sound signals, an external sound whose amplitude is to be reduced by the sound cancellation. The method then includes analyzing the identified external sound to determine whether the identified external sound is to be made audible to a user and, upon determining that the external sound is to be made audible to the user, the method includes modifying the sound cancellation so that the identified external sound is made audible to the user. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A merchandiser for storing a product for purchase by a customer is disclosed. The merchandiser includes a housing defining a cavity; a door coupled to the housing; a platform located in the cavity for holding the product; a load cell structured to measure a mass of the product; and a controller communicably coupled to the load cell. The controller is structured to unlock the door based on a validation of payment information of the customer, determine a weight of product removed during a transaction for the product, determine a type of the product removed from the ice merchandiser based on the determined weight, and determine an amount of currency required for the transaction for the product based on the determined type of product removed.

Abstract: The disclosed computer-implemented method may include establishing and implementing a virtual microphone. The method may include receiving an input specifying a location for a virtual microphone that is configured to capture audio as if located in the specified location. The method may next include initializing physical microphones to begin capturing audio as if located at the specified location. The physical microphones may be electronically or physically oriented to listen from the specified location. The method may then include combining audio streams from the physical microphones to generate a combined audio signal that sounds as if recorded at the specified location. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Calibration of a headset that uses bone conduction to provide audio content to a wearer is presented. A first tone of a plurality of tones that are at different frequencies is presented to the wearer via an air conduction transducer. A corresponding tone having a same frequency as the first tone is also presented to the wearer via a bone conduction (BC) transducer. The corresponding tone is adjusted such that a level of loudness is within a threshold range of a level of loudness of the first tone. An ear-canal sound pressure (ECSP) resulting from the first tone is recorded and a voltage applied to the BC transducer for generating the adjusted corresponding tone. An equalization filter is generated based in part on the ECSP and the voltage, the equalization filter for filtering an audio signal for presentation via the BC transducer.

Abstract: A method for manufacturing a cartilage conduction audio device is disclosed. A manufacturing system receives data describing a three-dimensional shape of an ear (e.g., the outer ear, behind the ear, the concha bowel, etc.) of a user. The system identifies one or more locations for one or more transducers along a back of an auricle of the ear for the user that vibrate the auricle over a frequency range causing the auricle to create an acoustic pressure wave at an entrance of the ear canal. The system then generates a design for a cartilage conduction audio device for the user based on the one or more identified locations of the transducers at which acoustic pressure waves generated by the one or more transducers satisfy a threshold performance metric for the user. The design may then be used to fabricate the cartilage conduction audio device.

Abstract: The invention relates to sweetening compositions obtained from the Luo Han Guo fruit, a member of the Cucurbiticeae family. The compositions are free of bitter-tasting impurities, have a light colour and contain about 16-75% mogroside V and about 30-95% total terpene glycosides on a dry weight basis. A filtered (0.2 ?m) solution of the composition in water with a solids content of 1% w/v has an absorbance at 420 nm of about 0.55 or below. Also disclosed is a method of preparing such compositions which includes a heating step to encourage the formation of melanoidins, highly coloured impurities, thereby permitting their removal by filtration providing a lighter coloured product.

Abstract: The disclosed computer-implemented method for performing natural language translation in AR may include accessing an audio input stream that includes words spoken by a speaking user in a first language. The method may next include performing active noise cancellation on the words in the audio input stream so that the spoken words are suppressed before reaching a listening user. Still further, the method may include processing the audio input stream to identify the words spoken by the speaking user, and translating the identified words spoken by the speaking user into a second, different language. The method may also include generating spoken words in the second, different language using the translated words, and replaying the generated spoken words in the second language to the listening user. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The disclosed computer-implemented method may include applying, via a sound reproduction system, sound cancellation that reduces an amplitude of various sound signals. The method further includes identifying, among the sound signals, an external sound whose amplitude is to be reduced by the sound cancellation. The method then includes analyzing the identified external sound to determine whether the identified external sound is to be made audible to a user and, upon determining that the external sound is to be made audible to the user, the method includes modifying the sound cancellation so that the identified external sound is made audible to the user. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The disclosed computer-implemented method may include establishing and implementing a virtual microphone. The method may include receiving an input specifying a location for a virtual microphone that is configured to capture audio as if located in the specified location. The method may next include initializing physical microphones to begin capturing audio as if located at the specified location. The physical microphones may be electronically or physically oriented to listen from the specified location. The method may then include combining audio streams from the physical microphones to generate a combined audio signal that sounds as if recorded at the specified location. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A system performs an optimization algorithm to optimize two or more acoustic sensors of a microphone array. The system obtains an array transfer function (ATF) for a plurality of combinations of the acoustic sensors of the microphone array. In a first embodiment, the algorithm optimizes an active set of acoustic sensors on the eyewear device. The plurality of combinations may be all possible combinations of subsets of the acoustic sensors that may be active. In a second embodiment, the algorithm optimizes a placement of two or more acoustic sensors on an eyewear device during manufacturing of the eyewear device. Each combination of acoustic sensors may represent a different arrangement of the acoustic sensors in the microphone array. In each embodiment, the system evaluates the obtained ATFs and, based on the evaluation, selects a combination of acoustic sensors for the microphone array.

Abstract: Techniques are described for performing dependency locking to enable parallel execution of database server processes modifying the same object. In an embodiment, a DBMS receives a request to execute an operation on its managed database. The request may include an object identifier and a version identifier for a version of a database object, which is required for the successful execution of the operation on the database. The required version of the database object may not exist and may be generated only after the execution of another, second, operation on the database. The first database server process initiates execution of the earlier received operation on the database. The first database server process queries the first database for the version of the particular database object and determines that the version of the database object does not exist yet, in one embodiment.

Abstract: A mud pump with components manufactured from high strength and toughness steel is disclosed. The mud pump includes a power end and a fluid end. The power end includes a motor, crankshaft rotationally engaged with the motor and a connecting rod rotationally engaged with the crank shaft. The fluid end is operatively connected to the power end and includes a piston, a cylinder configured to operatively engage the plunger, and a drilling fluid module. The crankshaft, the connecting rod, the piston, and the cylinder may each be fabricated from a high strength and toughness steel composition having the following composition in weight percent: 0.25-0.55% carbon, 0.70-1.50% manganese, a maximum of 0.80% silicon, 1.40-2.00% chromium, 0.10-0.55% molybdenum, a maximum of 0.040% aluminum, a maximum of 0.025% phosphorous, a maximum of 0.20% sulfur, a balance of iron, and incidental impurities.

Abstract: A backpack having a modifiable display. The backpack may include an active element arranged on an outer surface of the backpack, a power supply arranged on the backpack, and a controller arranged on the backpack and in electrical communication with the power supply and the active element. In some embodiments, the active element may include one or more drivers. The one or more drivers may be coated in a sealant, such as a rubber sealant. The active element may be a flexible display configured to display, such as an LED, LCD, OLED, AM-OLED, or EPD display. In some embodiments, the backpack may be part of a self-expression kit, and the modifiable display may be removable and configured for coupling to other surfaces. In some embodiments, the backpack may be part of an advertising network having a plurality of wearable articles and a digital marketplace for advertising opportunities.

Abstract: A method for manufacturing a cartilage conduction audio device is disclosed. A manufacturing system receives data describing a three-dimensional shape of an ear (e.g., the outer ear, behind the ear, the concha bowel, etc.) of a user. The system identifies one or more locations for one or more transducers along a back of an auricle of the ear for the user that vibrate the auricle over a frequency range causing the auricle to create an acoustic pressure wave at an entrance of the ear canal. The system then generates a design for a cartilage conduction audio device for the user based on the one or more identified locations of the transducers at which acoustic pressure waves generated by the one or more transducers satisfy a threshold performance metric for the user. The design may then be used to fabricate the cartilage conduction audio device.

Abstract: The disclosed computer-implemented method for performing directional beamforming according to an anticipated position may include accessing environment data indicating a sound source within an environment. The device may include various audio hardware components configured to generate steerable audio beams. The method may also include identifying the location of the sound source within the environment based on the accessed environment data, and then steering the audio beams of the device to the identified location of the sound source within the environment. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The disclosed computer-implemented method may include (1) establishing a communication channel to indirectly convey a conversation, (2) receiving, via the communication channel, a portion of the conversation, (3) presenting the portion of the conversation to a user, (4) receiving, via the communication channel, an additional portion of the conversation, (5) detecting an additional communication channel capable of conveying the conversation, (6) determining a human-perceivable difference between how the conversation has been conveyed via the communication channel and how the conversation will be conveyed via the additional communication channel, and (7) compensating for the human-perceivable difference when presenting the additional portion of the conversation to the user in order to smoothly transition the conversation from the communication channel to the additional communication channel. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Presented herein are systems and methods for question answering (QA). In embodiments, extractive question answering (QA) is cast as an iterative search problem through the document's structure: select the answer's sentence, start word, and end word. This representation reduces the space of each search step and allows computation to be conditionally allocated to promising search paths. In embodiments, globally normalizing the decision process and back-propagating through beam search makes this representation viable and learning efficient. Various model embodiments, referred to as Globally Normalized Readers (GNR), achieve excellent performance. Also introduced are embodiments of data-augmentation to produce semantically valid examples by aligning named entities to a knowledge base and performing swaps new entities of the same type. This methodology also improved the performance of GNR models and is of independent interest for a variety of natural language processing (NLP) tasks.

Abstract: The present disclosure features compounds such as those having the Formulae (I) and (II), which can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells. The present disclosure also features methods of treating a condition associated with decreased CFTR activity or a condition associated with a dysfunction of proteostasis comprising administering to a subject an effective amount of a disclosed compound, such as a compound of Formula (I) or (II).