Patents by Inventor John Milton

John Milton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Coupling method
    Patent number: 12473595
    Abstract: The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.
    Type: Grant
    Filed: March 28, 2025
    Date of Patent: November 18, 2025
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: James Anthony Clarke, James White, John Milton, Clive Gavin Brown
  • Polynucleotide synthesis method, system and kit
    Patent number: 12448635
    Abstract: The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: October 21, 2025
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: John Milton, Sobia Nayyar, Jan Riedl, Ryosuke Ogaki
  • COUPLING METHOD
    Publication number: 20250297305
    Abstract: The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.
    Type: Application
    Filed: December 3, 2024
    Publication date: September 25, 2025
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: James Anthony Clarke, James White, John Milton, Clive Gavin Brown
  • COUPLING METHOD
    Publication number: 20250290132
    Abstract: The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.
    Type: Application
    Filed: March 28, 2025
    Publication date: September 18, 2025
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: James Anthony Clarke, James White, John Milton, Clive Gavin Brown
  • POLYNUCLEOTIDE SYNTHESIS METHOD, KIT AND SYSTEM
    Publication number: 20250263767
    Abstract: The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide N sequence. The invention also relates to methods for the assembly of synthetic poly nucleotides following synthesis, as well as systems 0 and kits for performing the synthesis and/or assembly methods.
    Type: Application
    Filed: February 28, 2025
    Publication date: August 21, 2025
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: John Milton, Sobia Nayyar, Jan Riedl, Ryosuke Ogaki
  • Modified helicases
    Patent number: 12252717
    Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Grant
    Filed: October 18, 2022
    Date of Patent: March 18, 2025
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Andrew John Heron, James Anthony Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark John Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, David Antoni Alves, Rebecca Victoria Bowen, John Milton
  • POLYNUCLEOTIDE SYNTHESIS METHOD, KIT AND SYSTEM
    Publication number: 20250084468
    Abstract: The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods.
    Type: Application
    Filed: June 5, 2024
    Publication date: March 13, 2025
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: John Milton, Sobia Nayyar, Jan Riedl, Ryosuke Ogaki
  • MODIFIED HELICASES
    Publication number: 20240417704
    Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Application
    Filed: July 2, 2024
    Publication date: December 19, 2024
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Andrew John Heron, James Anthony Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark John Bruce, Lakmal Nishantha Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, David Antoni Alves, Rebecca Victoria Bowen, John Milton
  • Coupling method
    Patent number: 12152276
    Abstract: The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: November 26, 2024
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: James Anthony Clarke, James White, John Milton, Clive Gavin Brown
  • METHODS AND REAGENTS FOR SYNTHESISING POLYNUCLEOTIDE MOLECULES
    Publication number: 20240318219
    Abstract: The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods.
    Type: Application
    Filed: November 30, 2023
    Publication date: September 26, 2024
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: John Milton, Sobia Nayyar, Jan Riedl, Ryosuke Ogaki
  • Polynucleotide synthesis method, kit and system
    Patent number: 12037636
    Abstract: The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: July 16, 2024
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: John Milton, Sobia Nayyar, Jan Riedl, Ryosuke Ogaki
  • COUPLING METHOD
    Publication number: 20240158848
    Abstract: The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.
    Type: Application
    Filed: December 4, 2023
    Publication date: May 16, 2024
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: James Anthony Clarke, James White, John Milton, Clive Gavin Brown
  • Coupling method
    Patent number: 11959135
    Abstract: The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.
    Type: Grant
    Filed: October 7, 2020
    Date of Patent: April 16, 2024
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: James Anthony Clarke, James White, John Milton, Clive Gavin Brown
  • Coupling method
    Patent number: 11946102
    Abstract: The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.
    Type: Grant
    Filed: October 7, 2020
    Date of Patent: April 2, 2024
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: James Anthony Clarke, James White, John Milton, Clive Gavin Brown
  • Methods and reagents for synthesising polynucleotide molecules
    Patent number: 11884950
    Abstract: The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods.
    Type: Grant
    Filed: January 7, 2021
    Date of Patent: January 30, 2024
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: John Milton, Sobia Nayyar, Jan Riedl, Ryosuke Ogaki
  • MODIFIED HELICASES
    Publication number: 20230227799
    Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Application
    Filed: October 18, 2022
    Publication date: July 20, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Andrew John Heron, James Anthony Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark John Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, David Antoni Alves, Rebecca Victoria Bowen, John Milton
  • POLYNUCLEOTIDE SYNTHESIS METHOD, KIT AND SYSTEM
    Publication number: 20220396818
    Abstract: The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods.
    Type: Application
    Filed: September 10, 2020
    Publication date: December 15, 2022
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: John Milton, Sobia Nayyar, Jan Riedl, Ryosuke Ogaki, Marc George Wilkinson
  • Modified helicases
    Patent number: 11525126
    Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Grant
    Filed: October 6, 2020
    Date of Patent: December 13, 2022
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Andrew Heron, Anthony Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark John Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, David Antoni Alves, Rebecca Victoria Bowen, John Milton
  • POLYNUCLEOTIDE SYNTHESIS METHOD, KIT AND SYSTEM
    Publication number: 20220213537
    Abstract: The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods.
    Type: Application
    Filed: July 19, 2019
    Publication date: July 7, 2022
    Applicant: Oxford Nanopore Technologies Limited
    Inventors: John Milton, Sobia Nayyar, Jan Riedl, Ryosuke Ogaki
  • POLYNUCLEOTIDE SYNTHESIS METHOD, KIT AND SYSTEM
    Publication number: 20220177938
    Abstract: The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods.
    Type: Application
    Filed: July 19, 2019
    Publication date: June 9, 2022
    Applicant: Oxford Nanopore Technologies Limited
    Inventors: John Milton, Sobia Nayyar, Jan Riedl, Ryosuke Ogaki