Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.

Abstract: A method for improving z-axis strength of a 3D printed object is disclosed. For example, the method includes printing a three-dimensional (3D) object with a polymer and magnetic particles, heating the 3D object to a temperature at approximately a melting temperature of the polymer, and applying a magnetic field to the 3D object to locally move the magnetic particles in the polymer to generate heat and fuse the polymer around the magnetic particles to improve a z-axis strength of the 3D object.

Abstract: Systems disclosed herein are directed to a powered retail signage assembly having, inside a housing, a multi-layer translucent indicia panel and a light source panel emitting light to the rear of the multi-layer translucent indicia panel. The multi-layer translucent indicia panel includes a front tinted layer forming an indicium exposed on a front surface of the housing and a rear diffusion layer laminated with the front tinted layer at the back of the front tinted layer. The light emitted from the light source panel is diffused by the diffusion layer and transmitted through the tinted layer. The indicium appears brighter or darker than the front surface of the housing based on an external light condition.

Abstract: Disclosed herein are systems and method for forming a final hollow body from a metal strip. A forming system may include a forming station, a joining station, an inline heater, and a hydroforming station. Forming the final hollow body from the metal strip may include receiving the metal strip at the forming station and bending the metal strip to a desired cross-section with the forming station and such that longitudinal edges of the metal strip are abutting. In some aspects, the forming station includes at least one roller. The method may include welding the abutting longitudinal edges together as a seam region via the joining station and to form an intermediate hollow body. The method may include heating the seam region of the intermediate hollow body with the inline heater and hydroforming the intermediate hollow body to the final hollow body with the hydroforming station.

Abstract: Systems and methods are described for roll-forming metal substrates. The metal substrates are subjected to induction heating during the roll-forming process by exposure to time-varying magnetic fields, such as by exposure to a rotating permanent magnet, or exposure to laser radiation from a laser source. Heating of the metal substrates allows improved formability or plasticity of the substrate in order to reduce or eliminate damage to the substrate during roll-forming to low bending radius to thickness ratios. Heating of the high-strength metal substrates can also function to temper the substrates and/or improve surface corrosion resistance and form high-strength end products with desirable properties.

Abstract: Described are methods of treating surfaces of metal alloy substrates and associated metal alloy products. The methods may include providing an aluminum alloy product having a bulk and a surface and scanning abeam of high energy across the surface. The method may further include applying a liquid layer onto the surface prior to scanning a beam of high energy. The beam of high energy may interact with the surface and/or the liquid layer to form a treated surface. The beam of high energy may interact with the surface and/or the liquid layer to physically modify the at least a portion of the aluminum alloy product to form a treated sub-surface layer.

Abstract: Described are aluminum alloy products and methods of making aluminum alloy products in which the aluminum alloy products have carefully controlled intermetallic particle density and particle size. Such aluminum alloy products may exhibit favorable formability. Control over intermetallic particle size and density may allow for use of high amounts of recycled source content in aluminum alloy products.

Abstract: This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAs, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.

Abstract: This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAS, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.

Abstract: This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAS, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.

Abstract: A semiconductor die and an associated low resistance interconnect located primarily on the bottom surface of such die is disclosed. This arrangement provides a flexible packaging structure permitting easy interconnected with other integrated circuits; in this manner, a number of such circuits can be stacked to create high circuit density multi-chip modules. A process for making the device is further disclosed. To preserve structural integrity of a wafer containing such die during manufacturing, a through-hole via formed as part of the interconnect is filled with an inert material during operations associated with subsequent active device formation on such die.

Abstract: This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAs, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.

Abstract: The present invention relates to compositions and methods for delivering nucleic acid catalysts e.g., vascular endothelial growth factor receptor (VEGF-R-1) ribozyme, into a biological system.

Abstract: This invention features permeability enhancer molecules, and methods, to increase membrane permeability of negatively charged polymers thereby facilitating cellular uptake of such polymers.