Patents by Inventor John Misasi

John Misasi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODIES TARGETING THE SPIKE PROTEIN OF CORONAVIRUSES
    Publication number: 20240117011
    Abstract: Disclosed are monoclonal antibodies, antigen binding fragments, and bi-specific antibodies that specifically bind a coronavirus spike protein, such as SARS-CoV-2. Also disclosed is the use of these antibodies for inhibiting a coronavirus infection, such as a SARS-CoV-2 infection. In addition, disclosed are methods for detecting a coronavirus, such as SARS-CoV-2, in a biological sample, using the disclosed antibodies.
    Type: Application
    Filed: February 4, 2022
    Publication date: April 11, 2024
    Applicant: The U.S.A., as Represented by the Secretary, Department of Health and Human Services
    Inventors: John Misasi, Lingshu Wang, Chaim Aryeh Schramm, John R. Mascola, Daniel Cesar Douek, Nancy J. Sullivan, Amy Ransier Henry, Tongqing Zhou, Peter D. Kwong, Wei Shi, Yi Zhang, Eun Sung Yang, Mario Roederer, Rosemarie Diana Mason, Amarendra Pegu, Julie E. Ledgerwood
  • ANTI-SARS-COV-2 ANTIGEN BINDING POLYPEPTIDES, POLYPEPTIDE COMPLEXES AND METHODS OF USE THEREOF
    Publication number: 20240109955
    Abstract: Disclosed are antigen binding polypeptides and antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural and/or functional features. Also disclosed are polynucleotides and vectors encoding such polypeptides and polypeptide complexes; host cells, pharmaceutical compositions and kits containing such polypeptides and polypeptide complexes; and methods of using such polypeptides and polypeptide complexes.
    Type: Application
    Filed: June 30, 2023
    Publication date: April 4, 2024
    Inventors: Juan LI, Chi-Jen WEI, Ronnie R. WEI, Zhi-Yong YANG, John R. MASCOLA, Gary J. NABEL, John MISASI, Amarendra PEGU, Lingshu WANG, Tongqing ZHOU, Misook CHOE, Olamide K. OLONINIYI, Bingchun ZHAO, Yi ZHANG, Eun Sung YANG, Man CHEN, Kwanyee LEUNG, Wei SHI, Nancy J. SULLIVAN, Peter D. KWONG, Richard A. KOUP, Barney S. GRAHAM, Peng HE
  • EBOLA VIRUS GLYCOPROTEIN-SPECIFIC MONOCLONAL ANTIBODIES AND USES THEREOF
    Publication number: 20220089694
    Abstract: Human monoclonal antibodies that specifically bind Ebola virus glycoprotein with nanomolar affinity are described. The monoclonal antibodies were isolated by bulk sorting of plasmablasts from a human Ebola virus vaccinee and pairing of the immunoglobulin heavy and light chain genes using emulsion PCR. The paired immunoglobulin genes were expressed using Fab yeast display to screen and characterize the antibodies. The Ebola virus-specific monoclonal antibodies can be used, for example, to diagnose and treat Ebola virus infection or Ebola virus disease in a subject.
    Type: Application
    Filed: December 19, 2019
    Publication date: March 24, 2022
    Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventors: Nancy J. Sullivan, John Misasi, Brandon Dekosky, Kendra Elizabeth Leigh
  • NEUTRALIZING ANTIBODIES TO EBOLA VIRUS GLYCOPROTEIN AND THEIR USE
    Publication number: 20210079067
    Abstract: Antibodies and antigen binding fragments that specifically bind to ebolavirus glycoprotein and neutralize ebolavirus infection are disclosed. Nucleic acids encoding these antibodies, vectors, and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit an ebolavirus infection in a subject.
    Type: Application
    Filed: December 31, 2018
    Publication date: March 18, 2021
    Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventors: Nancy Sullivan, Kendra Leigh, John Misasi, Alberto Cagigi
  • KITS FOR MAKING RECYCLABLE COVALENTLY CROSSLINKED POLYMER NETWORKS, RECYCLABLE COMPOSITES, AND RELATED METHODS OF MAKING RECYCLABLE COMPOSITES AND RECYCLING COMPOSITES
    Publication number: 20190127515
    Abstract: Kits, recyclable covalently crosslinked polymer networks and composites, and related methods of making and recycling are described.
    Type: Application
    Filed: October 26, 2018
    Publication date: May 2, 2019
    Applicant: Western Washington University
    Inventors: John Misasi, Scott Lew
  • Nucleic acid arrays and methods of synthesis
    Publication number: 20020076716
    Abstract: The present invention generally relates to high density nucleic acid arrays and methods of synthesizing nucleic acid sequences on a solid surface. Specifically, the present invention contemplates the use of stabilized nucleic acid primer sequences immobilized on solid surfaces, and circular nucleic acid sequence templates combined with the use of isothermal rolling circle amplification to thereby increase nucleic acid sequence concentrations in a sample or on an array of nucleic acid sequences.
    Type: Application
    Filed: June 21, 2001
    Publication date: June 20, 2002
    Applicant: Trustees of Boston University
    Inventors: Chandran R. Sabanayagam, Takeshi Sano, John Misasi, Anson Hatch, Charles Cantor
  • Nucleic acid arrays and methods of synthesis
    Patent number: 6284497
    Abstract: The present invention generally relates to high density nucleic acid arrays and methods of synthesizing nucleic acid sequences on a solid surface. Specifically, the present invention contemplates the use of stabilized nucleic acid primer sequences immobilized on solid surfaces, and circular nucleic acid sequence templates combined with the use of isothermal rolling circle amplification to thereby increase nucleic acid sequence concentrations in a sample or on an array of nucleic acid sequences.
    Type: Grant
    Filed: April 8, 1999
    Date of Patent: September 4, 2001
    Assignee: Trustees of Boston University
    Inventors: Chandran R. Sabanayagam, Takeshi Sano, John Misasi, Anson Hatch, Charles Cantor