Abstract: A sensor module assembly for a respiratory therapy apparatus may be configured for a seal-based securement within a respiratory therapy device that includes a separable pneumatic block to make assembly or replacement more efficient. The sensor module assembly may include a flow manifold. The flow manifold may have an inlet and an outlet and a main pneumatic path between the inlet and the outlet. The assembly may have a sensor module with sensor(s) on a printed circuit board. The sensor module may be pneumatically and fixedly coupled to the flow manifold. The inlet of the flow manifold may be configured for removable coupling with an outlet of the pneumatic block assembly. Moreover, the outlet of the flow manifold may be configured for removable coupling with a pneumatic path of a housing panel of the respiratory therapy apparatus. The pneumatic path is adapted for supplying breathable gas to a patient interface.

Abstract: An engine system for a vehicle is described in which a turbocharger adapted to compress intake air is thermally coupled to a charge air cooler device operatively interposing the turbocharger and the engine. The system further includes a reconfigurable cooling system operable in three modes based on the flow of coolant and temperatures detected therein. In particular, the approach may be used to enhance engine warm-up in cold ambient conditions without costly additional devices.

Abstract: A turbocharger for an internal combustion engine comprising a housing wherein the housing comprises one or more coolant passages for receiving a coolant to cool the turbocharger and one or more lubricant passages for receiving a lubricant to lubricate the bearings. The lubricant may be the lubricant for both the turbocharger bearings and the internal combustion engine. The coolant passages and lubricant passages in the turbocharger may be arranged in the housing to transfer heat from the lubricant to the coolant such that the transfer of heat between the coolant passages and lubricant passages is sufficient to cool the lubricant to a temperature that is suitable for subsequent use in the internal combustion engine.

Abstract: The invention provides combinations comprising a MEK inhibitor (such as GDC-0973 or GDC-0623), or a pharmaceutically acceptable salt thereof and an ERK inhibitor (such as GDC-0994). The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.

Abstract: A turbocharger for an internal combustion engine comprising a housing wherein the housing comprises one or more coolant passages for receiving a coolant to cool the turbocharger and one or more lubricant passages for receiving a lubricant to lubricate the bearings. The lubricant may be the lubricant for both the turbocharger bearings and the internal combustion engine. The coolant passages and lubricant passages in the turbocharger may be arranged in the housing to transfer heat from the lubricant to the coolant such that the transfer of heat between the coolant passages and lubricant passages is sufficient to cool the lubricant to a temperature that is suitable for subsequent use in the internal combustion engine.

Abstract: The invention provides combinations comprising a MEK inhibitor (such as GDC-0973 or GDC-0623), or a pharmaceutically acceptable salt thereof and an ERK inhibitor (such as GDC-0994). The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.

Abstract: A process for producing nanoparticles comprises the steps of preparing silver seeds in the presence of a water soluble polyanionic polymer and growing the silver seeds to form nanoparticles. The polyanionic polymer may be poly(sodium styrenesulphonate).

Abstract: Biomarkers for screening subjects for Parkinson's disease and providing companion diagnostic tools for therapies using LRRK2 modulators, and assays for screening compounds and compositions for modulation of LRRK2 activity.

Abstract: An engine system for a vehicle is described in which a turbocharger adapted to compress intake air is thermally coupled to a charge air cooler device operatively interposing the turbocharger and the engine. The system further includes a reconfigurable cooling system operable in three modes based on the flow of coolant and temperatures detected therein. In particular, the approach may be used to enhance engine warm-up in cold ambient conditions without costly additional devices.

Abstract: A method for controlling a cooling system for a vehicle having an internal combustion engine permits rapid warm-up of the engine by the use of two electrically-operated valves in addition to a conventional thermostat. The method includes controlling a bypass valve and a heater valve to both remain closed at low coolant temperatures and engine speed to inhibit coolant flow through the engine. A control unit opens the bypass valve to prevent cavitation in the water pump if engine speed and/or load exceeds a certain value. The heater valve is opened when a threshold engine coolant temperature is reached permitting warming of the heater matrix.

Abstract: A cooling system for a vehicle having an internal combustion engine permits rapid warm-up of the engine by the use of two electrically-operated valves in addition to a conventional thermostat. A bypass valve and a heater valve both remain closed at low coolant temperatures and engine speeds, thereby inhibiting coolant flow through the engine. A control unit opens the bypass valve to prevent cavitation in the water pump if engine speed and/or load exceeds a certain value. The heater valve is opened when a threshold engine coolant temperature is reached permitting warming of the heater matrix.

Abstract: A sensor for detecting of an analyte in a solution phase comprises a plurality of functionalised silver nanoplates wherein a functionalising agent is directly bonded to the surfaces of the nanoplates. The nanoplates provide a detectable wavelength shift change in their local surface plasmon resonance spectrum in response to the binding of an analyte. Two or more of the nanoplates may be electromagnetically coupled.

Abstract: A heat exchanger is disclosed. The heat exchanger may have a conduit configured to conduct a fluid and at least one body of metal foam surrounding the conduit. The at least one body of metal foam may have a radially inner portion, a radially outer portion, and a radially intermediate portion between the radially inner portion and the radially outer portion. The at least one body of metal foam may have a lower percentage of void space at the radially outer portion as compared to the radially intermediate portion.

Abstract: A cooling system for a vehicle having an internal combustion engine permits rapid warm-up of the engine by the use of two electrically-operated valves in addition to a conventional thermostat. A bypass valve and a heater valve both remain closed at low coolant temperatures and engine speeds, thereby inhibiting coolant flow through the engine. A control unit opens the bypass valve to prevent cavitation in the water pump if engine speed and/or load exceeds a certain value. The heater valve is opened when a threshold engine coolant temperature is reached permitting warming of the heater matrix.

Abstract: A process for producing nanoparticles comprises the steps of preparing silver seeds in the presence of a water soluble polyanionic polymer and growing the silver seeds to form nanoparticles. The polyanionic polymer may be poly (sodium styrenesulphonate).

Abstract: An improved process for synthesising discrete high definition silver nanoparticles in large batch volumes. The method enables the reproducible production of silver nanoparticles having a predetermined size, shape and surface chemistry. The process comprises the steps of forming silver seeds from a reagent comprising, a silver source and a reducing agent; and growing the thus formed silver seeds into silver nanoparticles wherein the step forming silver seeds and/or growing the silver seeds into silver nanoparticles is performed using micro fluidic flow chemistry.

Abstract: The present invention is a quadrature VLIF receiver, including calibration circuitry, and methods to closely match signal processing of an in-phase signal path and a quadrature-phase signal path to optimize VLIF image rejection. The calibration circuitry includes a variable gain variable-phase calibration signal generator, a variable gain amplifier for each signal path, phase adjustment circuitry for each signal path, and switching circuitry to support calibration steps. The calibration signal generator supplies a calibration signal at the same frequency as mixer local oscillator signals; therefore, during calibration, all signals downstream of the VLIF mixer are at DC, which simplifies calibration measurements, thereby minimizing calibration times.

Abstract: Pumps for Steam Condensates and other Liquids, include receivers that may be connected firstly to the liquid source, and after filling are then pressurised to discharge the liquid to a transfer line, or to a vessel at a higher pressure than that of the source. The use of a small pilot valve to detect the liquid level, mounted externally to each receiver, and controlling the opening and closing of the pressurising and venting valves, enables an unusually low profile to be achieved.

Abstract: The present invention is a quadrature multi-mode RF receiver that uses a single quadrature mixer for tuning to desired frequency bands. In a direct conversion mode of operation, the RF receiver down converts a received RF signal directly into a baseband signal. In a VLIF mode of operation, the RF receiver down converts a received RF signal into a VLIF signal. When receiving a wanted RF signal, the frequency of the resulting VLIF signal is called the wanted VLIF frequency, and is based on the signal strength of the received RF signal. In one embodiment of the present invention, the wanted VLIF frequency is selected to be one of two VLIF frequencies. The wanted VLIF frequency is inversely related to the signal strength of the received RF signal.

Abstract: A heat exchanger is disclosed. The heat exchanger may have a conduit configured to conduct a fluid and at least one body of metal foam surrounding the conduit. The at least one body of metal foam may have a radially inner portion, a radially outer portion, and a radially intermediate portion between the radially inner portion and the radially outer portion. The at least one body of metal foam may have a lower percentage of void space at the radially outer portion as compared to the radially intermediate portion.