Abstract: The systems and method disclosed herein select a customized or default UE SIM profile for a registration with a particular network element in a specific jurisdiction based on the identification of the serving network element (e.g. MME, SGSN, S-CSCF). The default profile may be chosen over a particular subscriber identifier in various jurisdictions and types of networks. To implement the default profile, the subscription server may store a New Radio (NR) as a Secondary Radio Access Technologies (RAT) identifier, or “NR as a Secondary RAT” identifier, and set the value of the identifier as “ALLOW” or “DENY” of the default profile described herein.

Abstract: Ditosylate salts of N2-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine, and crystalline forms thereof; processes for the preparation of the new salt forms; and their use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer.

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: A component for a gas turbine engine, including: at least one internal cavity extending through the component, the internal cavity having at least one inlet opening and at least one outlet opening each being in fluid communication with the at least one internal cavity; a plurality of cooling features extending from a surface of the at least one internal cavity, the plurality of cooling features are formed in accordance with at least one of the following groups: i) a plurality of airfoil shaped features that extend upwardly from the surface of the at least one internal cavity and a plurality of wedge shaped features each having a triangular base that has an upstream portion and a downstream portion, the upstream portion extending further from the surface than the downstream portion; ii) a plurality features having a curved or “J” shaped base that extends upwardly from the surface, a plurality features having a double curved or symmetrically “J” shaped base that extends upwardly from the surface, and a pluralit

Abstract: The present invention is directed to novel heterodimeric antibodies.

Abstract: Diphosphate salts of N2-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine, and crystalline forms thereof, processes for the preparation of the new salt forms; and their use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer.

Abstract: An aircraft can include a stacked propeller to generate lift during assent and descent. The stacked propeller includes a first propeller and a second propeller that co-rotate about an axis of rotation. In one embodiment, the blades are coupled to a rotor mast that contains an internal cavity. In one mode of operation, the first propeller and/or the second propeller can be stored in the internal cavity in order to reduce drag during flight. The aircraft can include one or more stacked propellers, such as a port propeller and a starboard propeller, which rotate in opposite directions during one or more modes of flight.

Abstract: In one aspect, the present invention provides heterodimeric antibodies comprising a first monomer comprising a first heavy chain constant domain comprising a first variant Fc domain and a first antigen binding domain and a second monomer comprising a second heavy chain constant domain comprising a second variant Fc domain and a second antigen binding domain. In an additional aspect the heterodimeric antibody comprises a first monomer comprising a heavy chain comprising a first Fc domain and a single chain Fv region (scFv) that binds a first antigen, wherein the scFv comprises a charged scFv linker. The heterodimeric antibody further comprises a second monomer comprising a first heavy chain comprising a second Fc domain and a first variable heavy chain and a first light chain.

Abstract: A packet-filtering network appliance such as a threat intelligence gateway (TIG) protects TCP/IP networks from Internet threats by enforcing certain policies on in-transit packets that are crossing network boundaries. The policies are composed of packet filtering rules derived from cyber threat intelligence (CTI). Logs of rule-matching packets and their associated flows are sent to cyberanalysis applications located at security operations centers (SOCs) and operated by cyberanalysts. Some cyber threats/attacks, or incidents, are composed of many different flows occurring at a very high rate, which generates a flood of logs that may overwhelm computer, storage, network, and cyberanalysis resources, thereby compromising cyber defenses.

Abstract: A charge coupler with integrated electrical and mechanical disconnect switching can include a first member. A charging coupler can include a first member and a second member. The second member can be coupled at a first end with the first member. A charging coupler can include a first switch disposed at the first member and operable to cause, in response to a movement of the second member to a first angle with the first member that engages the first switch, a charging device to electrically decouple the charging device from a vehicle. A charging coupler can include a second switch disposed at the first member and operable to cause, in response to a movement of the second member to a second angle with the first member that engages the second switch, the charging device to mechanically decouple the charging device from the vehicle.

Abstract: A control housing assembly is disclosed. The housing assembly includes a housing and an escutcheon that manually connects to the housing by the engagement of escutcheon latches with housing catch channels. When the escutcheon is connected to the housing, the housing covers the escutcheon latches so as to obstruct the latches from being manually accessed to disengage the latches from the catch channels. The housing includes tool access slots through which a tool can be inserted to disengage a latch from a catch channel.

Abstract: A plurality of subimages of an image are generated based on output from a random number generator. Each subimage is input to a machine learning program trained to output an object classified in the subimage. When a number of subimages with a same classified object exceeds a threshold, an object in the image is identified as the classified object.

Abstract: Provided herein are novel anti-CD28×anti-B7H3 (also referred to as “?CD28×?B7H3”) heterodimeric bispecific antibodies and methods of using such antibodies for the treatment of cancers. Subject ?CD28×?B7H3 antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and targeting to B7H3 on tumor cells. Thus, such antibodies selectively enhance anti-tumor activity at tumor sites while minimizing peripheral toxicity. The subject antibodies provided herein are particularly useful for enhancing anti-tumor activity when used in combination with other anti-cancer therapies.

Abstract: A system is provided for measuring a thickness of a preform material. The system includes a material detection device and a controller, wherein the controller is configured to: receive, from the material detection device, a signal indicating a presence of the preform material; responsive to receiving the signal, receive a first set of measurements along at least a portion of a length of the preform material; convert the first set of measurements into a second set of measurements; and record the second set of measurements.

Abstract: Systems, methods, and storage media useful in a healthcare computing platform to build and publish an integrated medical consultation report to a patient's primary electronic medical record are provided. The integrated medical consultation report presents up-to-date objective medical factors from the patient's medical record concurrently with a subjective medical summary from an authoring clinician. The integrated medical consultation report is stored as a unique medical document in the patient's primary electronic record.

Abstract: Techniques for enrolling a user in a system's user recognition functionality without requiring the user speak particular speech are described. The system may determine characteristics unique to a user input. The system may generate an implicit voice profile from user inputs having similar characteristics. After an implicit voice profile is generated, the system may receive a user input having speech characteristics similar to that of the implicit voice profile. The system may ask the user if the user wants the system to associate the implicit voice profile with a particular user identifier. If the user responds affirmatively, the system may request an identifier of a user profile (e.g., a user name). In response to receiving the user's name, the system may identify a user profile associated with the name and associate the implicit voice profile with the user profile, thereby converting the implicit voice profile into an explicit voice profile.

Abstract: The invention relates to a mousse composition comprising: a) a base composition comprising: (i) from 0.0001 to 5 wt. % of a lactam; (ii) from 0.1 to 10 wt. % of an alcohol; and, b) a propellant; and to the use of a combination of a lactam with an alcohol, in a mousse composition to collapse the resulting mousse foam quicker; and to the use of a combination of a lactam with an alcohol, in a mousse composition to make the resulting mousse foam easier to rinse.

Abstract: An optical device includes a stack that includes a first curved optical element stacked with a second curved optical element. The second curved optical element propagates light by total internal reflection. The stack also includes an incoupling diffractive grating that incouples the light into the second optical element and an outcoupling diffractive grating optically coupled to the incoupling diffractive grating through the second curved optical element. The outcoupling diffractive grating directs the light. The first curved optical element has a first refractive index, the second curved optical element has a second refractive index, and the first refractive index is different from the second refractive index by approximately 0.15 to 1.2.

Abstract: A message limit value to be used in enqueuing one or more messages on a queue of a device of the computing environment is obtained. The message limit value indicates whether an extended maximum message length is supported by the device. The extended maximum message length is different from a default maximum message length supported by the device. Based on determining that the extended maximum message length is supported and that the obtained message limit value has a defined relationship with a select value, at least one message of an extended length is enqueued on the queue of the device.