Abstract: Assistive apparatuses or devices, kits, and methods for assisting with removal of a biological sample from an intraosseous device are described. Some of the present assistive apparatuses comprise: a body including a first end and a second end, and defining a channel with a first portion having a first transverse dimension, a second portion disposed between the first portion and the second end and having a second transverse dimension that is smaller than the first transvers dimension, and a longitudinal axis extending through the first portion and the second portion, the body further including a protrusion extending laterally outward relative to the longitudinal axis; where the channel is configured to receive a portion of an intraosseous device having a hub and a cannula extending from the hub, with the first portion of the channel receiving a part of the hub, and the second portion of the channel receiving a part of the cannula while preventing passage of the hub through the second portion.

Abstract: Provided herein are compounds of formula (II): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein wherein m, n, p, R1, R2, R3, L1, L2, L3, R4, X1, X2, X3, and X4 are as defined herein. Also provided are methods of preparing compounds of formula (II), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.

Abstract: The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate.

Abstract: Compositions for prevention of Foot and Mouth Disease (FMD) are provided, comprising an antigen component in the amount equivalent to 0.5-20 ?g FMD virus and an adjuvant component comprising oil, an immunostimulatory oligonucleotide, and a polycationic carrier. Methods of using the composition, as well as the methods of reducing FMD persistence are also provided.

Abstract: The invention provides stable coronavirus spike proteins. Immunogenic compositions comprising same and the methods of using these immunogenic compositions are also provided.

Abstract: The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.

Abstract: Embodiments disclosed herein relate to devices and systems for use in ophthalmic procedures. In some embodiments, a handpiece device for use with a surgical system is provided. The handpiece device includes a housing, a cable assembly, and a tapered optical fiber. The cable assembly is disposed through a distal end of the housing and optically coupled to the tapered optical fiber. The tapered optical fiber has a diameter that decreases between a proximal end of the tapered optical fiber and a distal end thereof. In some embodiments, the tapered optical fiber comprises a single-crystal fiber. In further embodiments, the tapered optical fiber comprises a tapered sapphire core fiber.

Abstract: Embodiments disclosed herein provide an optical fiber system. The optical fiber system includes an aspiration tube, an optical fiber external to the aspiration tube, and a sleeve surrounding the optical fiber and the aspiration tube. The sleeve includes a distal portion that defines a channel. The channel extends between the aspiration tube and a distal opening of the sleeve. The channel and the aspiration tube define an aspiration pathway. The optical fiber is partially disposed within the channel.

Abstract: The present invention is directed to novel nucleotide and amino acid sequences of Porcine Epidemic Diarrhea Virus (“PEDV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine PEDV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include polynucleotide constructs that replicate in tissue culture and in host swine. The invention also provides for novel full length PEDV genomes that can replicate efficiently in host animals and tissue culture.

Abstract: Systems and methods are disclosed comprising an ultrasonic handpiece having a housing, a working tip extending from the distal end of the housing, and a crystal and horn assembly positioned within the housing. The proximal end of the ultrasonic horn is free to move relative to the housing. In embodiments, the ultrasonic horn is resiliently suspended within the housing, with no rigid fixation points. The ultrasonic horn may be resiliently suspended by one or more resilient rings at the proximal end of the ultrasonic horn and by one or more resilient rings at the single nodal region of the ultrasonic horn. The ultrasonic handpiece may include a pumping module located at the proximal end of the handpiece.

Abstract: Disclosed herein are tissue scaffold materials with microspheres of one density embedded in hydrogel of a different density. The disclosed materials have improved ability to facilitate cellular invasion and vascularization for wound healing and tissue regeneration. The inventors have found that materials having components with different densities promotes invasion of cells, including desirable cells such as fibroblasts and endothelial precursor cells, into the scaffold.

Abstract: Techniques for zero clearing scalar moves are described. For example, one or more instructions are supported which, when executed, are to cause a scalar move of a 16-bit or 32-bit floating-point value from a source to a destination. When the destination is a vector register, all other data elements are to be zeroed.

Abstract: Systems, apparatuses and methods provide for technology that establishes an internet connection with an on-ground component, and receives a first instruction from the on-ground component over the internet connection. The technology further identifies the first instruction and modifies one or more parameters of the aircraft based on the first instruction.

Abstract: The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.

Abstract: The invention relates to an in-situ process for preparing an alkylphenol-aldehyde resin. The process comprises the step of providing a raw alkylphenol composition. The raw alkylphenol composition comprises one or more alkylphenol compounds and at least about 1 wt % phenol. Each alkylphenol compound has one or more alkyl substituents. The raw alkylphenol composition is reacted directly, without pre-purification, with one or more aldehydes to form an in-situ alkylphenol-aldehyde resin. The invention also relates to an in-situ alkylphenol-aldehyde resin formed from the in-situ process, and its use in a tackifier composition and rubber composition. The tackifier composition and rubber composition containing the in-situ alkylphenol-aldehyde resin show, inter alia, improved tack performance.

Abstract: Systems and methods are provided to process a digital photo and other media. An apparatus to process digital photos can include a tangibly embodied computer processor (CP) and a tangibly embodied database. The CP can perform processing including: (a) inputting a photo from a user device, and the photo including geographic data that represents a photo location at which the photo was generated; (b) comparing at least one area with the photo location and associating an area identifier to the photo as part of photo data; and (c) performing processing based on the area identifier and the photo data.

Abstract: The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate.

Abstract: Disclosed herein are tissue scaffold materials with microspheres of one density embedded in hydrogel of a different density. The disclosed materials have improved ability to facilitate cellular invasion and vascularization for wound healing and tissue regeneration. The inventors have found that materials having components with different densities promotes invasion of cells, including desirable cells such as fibroblasts and endothelial precursor cells, into the scaffold.

Abstract: Provided herein are compounds of formula (II): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, R2, R3, R5, R6, R7, R8, R9, R10, R11a, R11b, and X are as defined elsewhere herein. Also provided herein are methods of preparing compounds of formula (II). Also provided herein are methods of inhibiting SLC6A19 and methods of treating a SLC6A19-mediated disease, disorder, or condition in an individual in need thereof.