Abstract: Systems and methods are provided for a supply knowledge portal. The supply knowledge portal provides a new metric dashboard that delivers real-time information on the status and health of the hospital supply chain. The new dashboard is driven by the transactional data generated from system point of use devices and allows end users to view data at various levels starting at the facility level and moving down to filter for specific areas, devices and, at the lowest level, items.

Abstract: The present invention is directed to combinations of a ?-lactamase inhibitor with sulbactam and, optionally, imipenem/cilastatin. The combinations are useful for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant pathogens. More particularly, the invention relates to a combination of ?-lactamase inhibitor compound 1: or a pharmaceutically acceptable salt thereof, with sulbactam, or a pharmaceutically acceptable salt thereof, and, optionally, imipenem/cilastatin, or a pharmaceutically acceptable salt thereof.

Abstract: A VTOL aircraft has a substantially delta-shaped lifting body fuselage with airfoils disposed along all three sides. In vertical flight mode the airfoils act as exhaust diverters. A flow of exhaust gas flows from a centrally located vertical flight gas diffuser over the top surface of the lifting body and then is directed downward by the airfoils to provide vertical lift. In vertical flight mode, the entirety of the exhaust from the engine is diverted to the vertical flight gas diffuser by means of a transition duct that diverts the flow of gas through a 90° upward bend into the vertical flight gas diffuser. In horizontal flight mode the transition duct is fully retracted to permits the entirety of the engine thrust to be directed rearward to propel the aircraft in a horizontal flight mode.

Abstract: Systems and methods are provided for a supply knowledge portal. The supply knowledge portal provides a new metric dashboard that delivers real-time information on the status and health of the hospital supply chain. The new dashboard is driven by the transactional data generated from system point of use devices and allows end users to view data at various levels starting at the facility level and moving down to filter for specific areas, devices and, at the lowest level, items.

Abstract: The present invention is directed to combinations of a ?-lactamase inhibitor with sulbactam and, optionally, imipenem/cilastatin. The combinations are useful for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant pathogens. More particularly, the invention relates to a combination of ?-lactamase inhibitor compound 1: or a pharmaceutically acceptable salt thereof, with sulbactam, or a pharmaceutically acceptable salt thereof, and, optionally, imipenem/cilastatin, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention is directed to combinations of a ?-lactamase inhibitor with sulbactam and, optionally, imipenem/cilastatin. The combinations are useful for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant pathogens. More particularly, the invention relates to a combination of ?-lactamase inhibitor compound 1: or a pharmaceutically acceptable salt thereof, with sulbactam, or a pharmaceutically acceptable salt thereof, and, optionally, imipenem/cilastatin, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention is directed to combinations of a ?-lactamase inhibitor with sulbactam and, optionally, imipenem/cilastatin. The combinations are useful for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant pathogens. More particularly, the invention relates to a combination of ?-lactamase inhibitor compound 1: or a pharmaceutically acceptable salt thereof, with sulbactam, or a pharmaceutically acceptable salt thereof, and, optionally, imipenem/cilastatin, or a pharmaceutically acceptable salt thereof.

Abstract: A method and system is disclosed for operating a fantasy sports league independent of actual game-based time keeping or actual game-based segmenting such as innings, quarters, periods, halves, etc. The method includes storing, in a computer database, statistical performance data for a set of real-world athletes, time-stamping each statistic or player performance metric at a time the statistic or player performance metric was monitored, defining qualifying statistics and player performance metrics for accrual into a fantasy sports point system based upon the time-stamp associated with the statistic and player performance metric, and scoring the fantasy league based upon a user defined time range.

Abstract: A cleaning device having a handle, the handle having a cleaning pad assembly capable of pivoting between a cleaning position and a rinsing position. The handle of the cleaning device may further comprise a conduit for directing the flow of a liquid from a liquid input to a liquid output, the liquid output being capable of direction either though the cleaning pad to wet the cleaning pad or at a surface to rinse a surface. The cleaning device may further comprise a valve, the valve being operable to control the flow of water through the handle.

Abstract: An improved showerhead provides a fluid diverter valve that allows quick connection and disconnection of a hand held sprayer used for cleaning shower stalls and bathrooms. The diverter valve includes a valve housing having a water inlet, a first water outlet and a second water outlet. A valve runner moves between a first position wherein the valve runner seats to permit fluid communication between the inlet and the first outlet and a second position wherein the valve runner seats to permit fluid communication between the inlet and the second outlet. The valve runner is moved from the first position to the second position substantially by gravity.

Abstract: A cleaning device having a handle, the handle having a cleaning pad assembly capable of pivoting between a cleaning position and a rinsing position. The handle of the cleaning device may further comprise a conduit for directing the flow of a liquid from a liquid input to a liquid output, the liquid output being capable of direction either though the cleaning pad to wet the cleaning pad or at a surface to rinse a surface. The cleaning device may further comprise a valve, the valve being operable to control the flow of water through the handle.

Abstract: Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention and treatment of Type 1 diabetes mellitus. The chimeric fusion proteins of the invention are useful in predicting risk of onset of Type 1 diabetes, determining prognosis of Type 1 diabetes patients early in disease progression, and in evaluating patients for suitability as recipients of transplants of pancreatic cells or tissues. The administration of the proteins of the invention in accordance with the immunomodulatory methods of the invention results in beneficial effects on disease development and severity in patients suffering from or predicted to be at risk of developing Type 1 diabetes, as well as on the outcome of transplants of pancreatic cells or tissues in Type 1 diabetes patients.

Abstract: Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention and treatment of Type 1 diabetes mellitus. The chimeric fusion proteins of the invention are useful in predicting risk of onset of Type I diabetes, determining prognosis of Type 1 diabetes patients early in disease progression, and in evaluating patients for suitability as recipients of transplants of pancreatic cells or tissues. The administration of the proteins of the invention in accordance with the immunomodulatory methods of the invention results in beneficial effects on disease development and severity in patients suffering from or predicted to be at risk of developing Type 1 diabetes, as well as on the outcome of transplants of pancreatic cells or tissues in Type I diabetes patients.

Abstract: A system is provided for sensing blood glucose data of a patient. The system includes a sensor, user interface, and an optional auxiliary device. If the connection between the sensor and user interface is by a wire, the sensor remains powered when the wire is disconnected. The communication between the sensor and the user interface may be wireless. The auxiliary device can be a patient monitor or other display or signal device, which displays information about the blood glucose data collected by the sensor. The sensor is connected to sensor electronics, which include a sensor power supply, a voltage regulator, and optionally a memory and processor.

Abstract: A spray nozzle (10) has a nozzle body (20) with an inlet (24) and an outlet (26). The inlet (24) is attachable to a hose (2). The outlet (26) is configured to receive a chemically-containing cartridge (70). A forwardly-disposed trigger (30) is finger-actuated and operates the valve (52) of a first valve assembly (50) to control water flow through the nozzle (10). An inlet conduit (56) connects the first valve assembly (50) to a second valve assembly (60). The second valve assembly (60) is thumb-actuated by a toggle (40) to pass water through the nozzle (10) as clean water supplied to the nozzle (10) via the hose (2) or through the nozzle (10) as chemical-added water that is created by a venturi-induced assembly (80) contained within the cartridge (70).

Abstract: A system is provided for sensing blood glucose data of a patient. The system includes a sensor, user interface, and an optional auxiliary device. If the connection between the sensor and user interface is by a wire, the sensor remains powered when the wire is disconnected. The communication between the sensor and the user interface may be wireless. The auxiliary device can be a patient monitor or other display or signal device, which displays information about the blood glucose data collected by the sensor. The sensor is connected to sensor electronics, which include a sensor power supply, a voltage regulator, and optionally a memory and processor.

Abstract: An improved showerhead provides a fluid diverter valve that allows quick connection and disconnection of a hand held sprayer used for cleaning shower stalls and bathrooms. The diverter valve includes a valve housing having a water inlet, a first water outlet and a second water outlet. A valve runner moves between a first position wherein the valve runner seats to permit fluid communication between the inlet and the first outlet and a second position wherein the valve runner seats to permit fluid communication between the inlet and the second outlet. The valve runner is moved from the first position to the second position substantially by gravity.

Abstract: An external infusion device for delivering insulin from a reservoir into a body of a user includes the capability to deliver time-shifted basal insulin. The external infusion device includes at least one drive mechanism operatively couplable to the reservoir to deliver insulin into the body of the user, at least one processor to control the external infusion device, at least one power supply, at least one display device operatively coupled to the processor to provide visual information to the user, at least one input device operatively coupled to the processor to allow the user to command the processor, and a housing. Time-shifting of basal insulin occurs when a portion of basal insulin is added to a bolus, to a current basal rate, or to a bolus and a current basal rate.

Abstract: The present invention provides for a sleeve that screws into the same opening in a faucet that a typical aerator screws into. This sleeve replaces the aerator and includes a smaller aerator that is inserted within the sleeve. In this fashion, water aeration can still occur when aeration is desired. However, when a hose attachment is inserted into the sleeve, one of the hose attachment moves up and into the sleeve.

Abstract: An infusion system is for infusing a fluid into the body of a patient. The infusion system includes at least one sensor for monitoring blood glucose concentration of the patient and an infusion device for delivering fluid to the patient. The sensor produces at least one sensor signal input. The infusion device uses the at least one sensor signal input and a derivative predicted algorithm to determine future blood glucose levels. The infusion device delivers fluid to the patient when future blood glucose levels are in a patient's target range. The infusion device is capable of suspending and resuming fluid delivery based on future blood glucose levels and a patient's low shutoff threshold. The infusion device suspends fluid delivery when future blood glucose levels falls below the low shutoff threshold. The infusion device resumes fluid delivery when a future blood glucose level is above the low shutoff threshold.