Abstract: A generator module for a vehicle includes a housing with a first conical surface, a rotor assembly with a second conical surface, aligned with the first conical surface, and a spring arranged to push the second conical surface into contact with the first conical surface. In an example embodiment, the first conical surface or the second conical surface includes a plastic surface or a friction paper surface. In an example embodiment, the rotor assembly is axially displaceable within the housing to compress the spring and move the second conical surface away from the first conical surface.

Abstract: A method and system for dispersing stored energy in an energy storage system to delay or arrest propagation of thermal runaway and thermally-induced cascading failures. The system includes a plurality of battery sub-assemblies and DC-DC converters connected to a shared DC bus through which energy may be exchanged. The system may be interfaced to an AC power grid or DC power system through an additional power converter. The method of dispersing stored energy uses this system to charge and discharge sub-assemblies such that the system is less susceptible to propagation of thermal runaway. The method determines, based on awareness of current system state, battery types, and electrical and thermal structure, the sequence of charging and discharging actions to best inhibit thermal runaway while preserving the system's ability to perform subsequent energy redistribution.

Abstract: This invention generally relates to the field of somatic gene therapy. The invention provides a nucleic acid construct comprising a transgene encoding a therapeutic protein, a tetracycline-responsive aptazyme sequence, and inverted terminal repeats (ITRs). The nucleic acid construct can be transferred to a subject in need thereof in the form of a viral vector, in particular an adeno-associated virus (AAV) vector. The Tet-responsive aptazyme sequence allows for a tightly controlled expression of the transgene in the subject, thereby avoiding toxic side effects. The nucleic acid construct and the viral vectors comprising same are particularly useful in the treatment of proliferative diseases like cancer.

Abstract: Ingestible devices capable of delivering a dispensable substance, such as, for example, a therapeutic agent, as well as related components, systems and methods, are disclosed. A removably attachable storage reservoir configured to be used with an ingestible device and capable of storing dispensable substance, such as, for example, a therapeutic agent, as well as related components, systems and methods, are also disclosed.

Abstract: A method for recycling powdered paint waste is provided in which, the powdered paint waste is being treated with the aid of a reactant in such a way that its adhesion to surfaces and especially to metal surfaces is reduced or eliminated. The treatment of the powdered paint waste allows the powdered paint waste to be additionally processed under the influence of heat and to use it as a starting material in various recycling processes or in other processes.

Abstract: Systems and methods are provided for a supply knowledge portal. The supply knowledge portal provides a new metric dashboard that delivers real-time information on the status and health of the hospital supply chain. The new dashboard is driven by the transactional data generated from system point of use devices and allows end users to view data at various levels starting at the facility level and moving down to filter for specific areas, devices and, at the lowest level, items.

Abstract: A method for rendering material surfaces inert is provided. Exemplary surfaces include ceramic, metal or plastic surfaces. The method is accomplished with functionalized perfluorinated compounds for the formation of hyperhydrophobic structures on the surfaces to create inert surfaces. The inert surfaces produced or can be produced in this way have an extremely low surface energy, are resistant to deposits of substances or cells and have a very low coefficient of friction. Practical uses of the inert surfaces are also provided.

Abstract: This disclosure details overmolded vehicle sheet metal structures that included integrated attachments for achieving part integration. An exemplary sheet metal structure includes a sheet metal panel, a reinforcing structure molded on the sheet metal panel, and an integrally molded attachment structure formed within the reinforcing structure. In some embodiments, the integrally molded attachment structure may include a nut, a bracket, or both. An additional vehicle component may be attached to the sheet metal panel via the integrally molded attachment structure. The sheet metal structure may be formed in a single shot injection molding process.

Abstract: This disclosure details overmolded vehicle sheet metal structures that included integrated attachments for achieving part integration. An exemplary sheet metal structure includes a sheet metal panel, a reinforcing structure molded on the sheet metal panel, and an integrally molded attachment structure formed within the reinforcing structure. In some embodiments, the integrally molded attachment structure may include a nut, a bracket, or both. An additional vehicle component may be attached to the sheet metal panel via the integrally molded attachment structure. The sheet metal structure may be formed in a single shot injection molding process.

Abstract: A method for recycling powdered paint waste is provided in which, the powdered paint waste is being treated with the aid of a reactant in such a way that its adhesion to surfaces and especially to metal surfaces is reduced or eliminated. The treatment of the powdered paint waste allows the powdered paint waste to be additionally processed under the influence of heat and to use it as a starting material in various recycling processes or in other processes.

Abstract: An apparatus and method are provided for transporting cargo over a cargo bed. The apparatus includes a first rail, having a first key and a second key, and a first track member including (a) a first keyway having a first end and a second end, (b) a second keyway axially aligned with the first end and (c) a third keyway axially aligned with the second end.

Abstract: An accessory support for a vehicle cargo area includes a guide assembly adapted to provide vertical and lateral adjustability and at least one support member slidably carried by the guide assembly. The guide assembly includes a first pair of guide rails each including one or more vehicle z-axis oriented guide channels and a second pair of guide rails each including one or more vehicle y-axis oriented guide channels.

Abstract: The present invention is directed to combinations of a ?-lactamase inhibitor with sulbactam and, optionally, imipenem/cilastatin. The combinations are useful for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant pathogens. More particularly, the invention relates to a combination of ?-lactamase inhibitor compound 1: or a pharmaceutically acceptable salt thereof, with sulbactam, or a pharmaceutically acceptable salt thereof, and, optionally, imipenem/cilastatin, or a pharmaceutically acceptable salt thereof.

Abstract: A VTOL aircraft has a substantially delta-shaped lifting body fuselage with airfoils disposed along all three sides. In vertical flight mode the airfoils act as exhaust diverters. A flow of exhaust gas flows from a centrally located vertical flight gas diffuser over the top surface of the lifting body and then is directed downward by the airfoils to provide vertical lift. In vertical flight mode, the entirety of the exhaust from the engine is diverted to the vertical flight gas diffuser by means of a transition duct that diverts the flow of gas through a 90° upward bend into the vertical flight gas diffuser. In horizontal flight mode the transition duct is fully retracted to permits the entirety of the engine thrust to be directed rearward to propel the aircraft in a horizontal flight mode.

Abstract: Systems and methods are provided for a supply knowledge portal. The supply knowledge portal provides a new metric dashboard that delivers real-time information on the status and health of the hospital supply chain. The new dashboard is driven by the transactional data generated from system point of use devices and allows end users to view data at various levels starting at the facility level and moving down to filter for specific areas, devices and, at the lowest level, items.

Abstract: The present invention is directed to combinations of a ?-lactamase inhibitor with sulbactam and, optionally, imipenem/cilastatin. The combinations are useful for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant pathogens. More particularly, the invention relates to a combination of ?-lactamase inhibitor compound 1: or a pharmaceutically acceptable salt thereof, with sulbactam, or a pharmaceutically acceptable salt thereof, and, optionally, imipenem/cilastatin, or a pharmaceutically acceptable salt thereof.

Abstract: An accessory support for a vehicle cargo area includes a guide assembly adapted to provide vertical and lateral adjustability and at least one support member slidably carried by the guide assembly. The guide assembly includes a first pair of guide rails each including one or more vehicle z-axis oriented guide channels and a second pair of guide rails each including one or more vehicle y-axis oriented guide channels.

Abstract: A vehicle body assembly may include a header, a roof rail, and a gusset component. The header may define a lateral axis extending across a vehicle body. The roof rail may define a longitudinal axis extending fore/aft along the vehicle body. The gusset component is for securing the header and roof rail to one another and includes an edge extending diagonally between the header and the roof rail to reinforce a vehicle body corner joint. The edge may extend diagonally from the header to the roof rail at an angle between thirty and sixty degrees relative to the lateral axis and the longitudinal axis. The edge may define an edge axis oriented at substantially forty-five degrees relative to the lateral axis.

Abstract: The present invention is directed to combinations of a ?-lactamase inhibitor with sulbactam and, optionally, imipenem/cilastatin. The combinations are useful for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant pathogens. More particularly, the invention relates to a combination of ?-lactamase inhibitor compound 1: or a pharmaceutically acceptable salt thereof, with sulbactam, or a pharmaceutically acceptable salt thereof, and, optionally, imipenem/cilastatin, or a pharmaceutically acceptable salt thereof.

Abstract: An apparatus and method are provided for transporting cargo over a cargo bed. The apparatus includes a first rail, having a first key and a second key, and a first track member including (a) a first keyway having a first end and a second end, (b) a second keyway axially aligned with the first end and (c) a third keyway axially aligned with the second end.