Abstract: According to the disclosure, a cartridge for detecting a target analyte mounted on a target analyte detection device, comprising: a base, a plurality of chambers provided on the base and comprising a sample chamber, and a plurality of channels provided on the base and comprising a sample channel connected to the sample chamber. The sample chamber comprises an injection hole provided on the base and comprising an inlet into which the sample is introduced, a sample delivery passage connecting the injection hole, and a sample filter provided on between the outlet of the sample delivery passage and the sample channel. The sample delivery passage comprises an asymmetric cross-sectional shape.

Abstract: According to the disclosure, a cartridge for detecting a target analyte, comprising: a base, a sample chamber, a first mixing chamber accommodating a magnetic bead, a second mixing chamber accommodating a dry reagent, a shuttle chamber for dissolving the dry reagent of the second mixing chamber, and a detection chamber for detecting the target analyte. The shuttle chamber is configured to dissolve the dry reagent in a sample solution provided from the first mixing chamber. The fluid in the second mixing chamber is moved to the shuttle chamber by positive pressure provided from the first pneumatic port, or the fluid in the shuttle chamber is moved to the second mixing chamber by negative pressure provided from the first pneumatic port.

Abstract: An electrochemical deposition fountain reactor for processing spinning semiconductor wafers can include a perforated ionic membrane near the wafer surface through which electrolyte flows. This allows high velocity electrolyte jets to impinge the wafer surface at low bulk flow rates, which reduces the boundary layer at the wafer surface and allows for better replenishment of ions at the wafer surface.

Abstract: An electrochemical deposition fountain reactor for processing spinning semiconductor wafers can include a perforated ionic membrane near the wafer surface through which electrolyte flows. This allows high velocity electrolyte jets to impinge the wafer surface at low bulk flow rates, which reduces the boundary layer at the wafer surface and allows for better replenishment of ions at the wafer surface.

Abstract: According to the disclosure, a cartridge for detecting a target analyte, comprising: a base, a sample chamber, a first mixing chamber accommodating a magnetic bead, a liquid storage chamber storing a liquid, a detection chamber for detecting the target analyte, a plurality of liquid transport channels for transporting fluid of the liquid storage chamber to the first mixing chamber, and a mixing channel connected to the first mixing chamber. The first mixing chamber comprises an opening formed in a first surface of the base, a concave surface provided recessed from the first surface of the base, and a side wall connecting the concave surface and the first surface of the base. At least one of the liquid transport channels is connected to the concave surface of the first mixing chamber.

Abstract: According to the disclosure, a cartridge for detecting a target analyte, comprising: a base comprising a first surface, a second surface opposite to the first surface, and side surfaces connecting between the first surface and the second surface; a chamber recessed from the first surface of the base; and an inflow channel recessed from the first surface of the base and connected to upper portion of the chamber. The chamber comprises an accommodation room for accommodating liquid, an inlet port connected the inflow channel, a guide groove for guiding liquid introduced from the inlet port downward to the accommodation room, and a barrier structure for preventing back flow of liquid from the guide groove toward the inlet port.

Abstract: An apparatus configured to detect small particles of a substance suspended in a matrix using ultrasound, may include: a container device configured to receive a sample in an inner volume, including: a first ultrasonic transducer mechanically coupled to or disposed on a first exterior portion of the container device and oriented toward the inner volume, the first ultrasonic transducer may include: a first ultrasonic transmitter; and a first ultrasonic receiver; optionally a first receiver amplifier coupled to the first receiver; optionally the first transmitter amplifier coupled to the first transmitter amplifier; and either: a) a software defined radio (SDR), or b) a signal generator and an oscilloscope, where SDR or signal generator and oscilloscope are electronically coupled to the first ultrasonic transmitter and electronically coupled to the first ultrasonic receiver amplifier; and the electronic controller coupled to the SDR or the signal generator and the oscilloscope.

Abstract: A combination therapy including one or more compounds of formula (I): wherein R represents hydrogen, halo, cyano, C1-4 haloalkyl, C1-4 haloalkoxy, or SO2NR5R6, R1a and R1b independently represent hydrogen or halo; R2 represents hydrogen, halo, cyano, C1-4 alkyl, C1-4 alkoxy, or C1-4 haloalkoxy; R3 represents halo, cyano, C1-4 alkyl, or C1-4 hydroxyalkyl; R4 represents hydrogen or C1-4 alkyl; X represents CH or N; Y represents N or CH which carbon atom may optionally be substituted by R, R1a or R1b; R5 and R6 independently represent hydrogen or C1-4 alkyl; or a pharmaceutically acceptable salt thereof; and a second or further active ingredient.

Abstract: The present specification provides an electric battery monitoring system. The system has particular application in electric vehicles where there it is desired to balance energy consumption to preserve vehicle range while also periodically monitoring for unsafe conditions that could lead to a thermal event.

Abstract: In an example, a method includes depositing an organic polymer layer on one or more material layers. The method also includes thermally curing the organic polymer layer. The method includes depositing a hard mask on the organic polymer layer and depositing a photoresist layer on the hard mask. The method also includes patterning the photoresist layer to expose at least a portion of the hard mask. The method includes etching the exposed portion of the hard mask to expose at least a portion of the organic polymer layer. The method also includes etching the exposed portion of the organic polymer layer to expose at least a portion of the one or more material layers.

Abstract: A method of suturing a trocar path incision in a tissue of a patient with an obturator includes inserting the obturator through the tissue such that a shaft of the obturator extends through a tissue opening about the trocar path incision and a distal tip of the obturator is positioned within a cavity of the patient. The method also includes directing the suture via a suturing feature with the obturator inserted through the tissue in order to direct the suture relative to the tissue. Furthermore, the method includes closing the tissue opening about the trocar path incision with the suture.

Abstract: A compact utility loader incorporating a boom of adjustable length. The boom may include one or more lift arm assemblies, with each lift arm assembly including a first lift arm that telescopically receives a second lift arm. Each lift arm assembly also includes a telescoping actuator adapted to telescopically extend and retract its second lift arm relative to its first lift arm. A load-sensing system may be provided and adapted to limit lift arm assembly extension based at least in part upon a tool load applied at a tool supported by the boom.

Abstract: Systems and methods for selecting a treatment regimen for a particular patient are provided. The treatment regimen is selected using a first data store including a first plurality of patient records for a first plurality of patients, and a second data store including efficacy rates of a plurality of treatment regimens against a plurality of infections and infection-causing pathogens. The system, or a user of the system, identifies a first infection of the particular patient and a first treatment regimen to be prescribed to treat the first infection. A second plurality of patient records is generated by identifying, in the first plurality of patient records of the first data store, patient records associated with diagnosis or treatment of the first infection. The second plurality of patient records are appended with efficacy rates for the first infection from the second data store.

Abstract: Described herein are example methods and systems for neuro-behavioral relationships in dimensional geometric bedding (N-BRIDGE), which includes a comprehensive, data-driven analytic framework for mapping the multi-dimensional relationships between neural and behavioral features in humans N-BRIDGE allows mapping of variations along newly-defined data-driven behavioral dimensions that capture the geometry of behavioral/symptom variation to variation in specific neural features.

Abstract: A circuit configured to transmit frequency multiplexed signals from a superconducting domain to a higher temperature domain. The circuit comprising a multiplexed signal output and a plurality of superconducting oscillator circuits each configured to output a different carrier frequency, each superconducting oscillator circuit comprising an oscillator output connected to the multiplexed signal output. Each superconducting oscillator circuit comprising a converter stage configured to convert an input of a superconducting logic signal to a Single Flux Quantum (SFQ) bit value, a splitter stage electrically connected to an output of the converter stage, the splitter stage configured to change between a first current state and a second current state based at least in part on the SFQ bit value, and an oscillator stage magnetically coupled to an output of the splitter stage and electrically coupled to the oscillator output.

Abstract: A circuit configured to transmit frequency multiplexed signals from a superconducting domain to a higher temperature domain. The circuit comprising a multiplexed signal output and a plurality of superconducting oscillator circuits each configured to output a different carrier frequency, each superconducting oscillator circuit comprising an oscillator output connected to the multiplexed signal output. Each superconducting oscillator circuit comprising a converter stage configured to convert an input of a superconducting logic signal to a Single Flux Quantum (SFQ) bit value, a splitter stage electrically connected to an output of the converter stage, the splitter stage configured to change between a first current state and a second current state based at least in part on the SFQ bit value, and an oscillator stage magnetically coupled to an output of the splitter stage and electrically coupled to the oscillator output.

Abstract: A method for attaching a prepared sample to a carrier in a focused ion beam chamber. The method includes reducing a temperature within the chamber to substantially below room temperature followed by moving the prepared sample adjacent to a substrate carrier surface. The temperature can be lowered sufficiently to establish a cryogenic condition in the chamber. Attachment of the prepared sample to the substrate carrier is done by controlling the focused ion beam to raster a target area of the surface in the absence of a gas deposition precursor, to sputter material onto the base of the sample and the substrate carrier surface, thereby binding the prepared sample to the substrate carrier.

Abstract: Systems and methods for selecting a treatment regimen for a particular patient are provided. The treatment regimen is selected using a first data store including a first plurality of patient records for a first plurality of patients, and a second data store including efficacy rates of a plurality of treatment regimens against a plurality of infections and infection-causing pathogens. The system, or a user of the system, identifies a first infection of the particular patient and a first treatment regimen to be prescribed to treat the first infection. A second plurality of patient records is generated by identifying, in the first plurality of patient records of the first data store, patient records associated with diagnosis or treatment of the first infection. The second plurality of patient records are appended with efficacy rates for the first infection from the second data store.