Patents by Inventor John Mykytiuk

John Mykytiuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Salt form
    Patent number: 11964972
    Abstract: Ditosylate salts of N2-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine, and crystalline forms thereof; processes for the preparation of the new salt forms; and their use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: April 23, 2024
    Assignee: CRT Pioneer Fund LP
    Inventors: Julian S. Northen, John Mykytiuk, Gillian Moore
  • Salt form
    Patent number: 11945814
    Abstract: Diphosphate salts of N2-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine, and crystalline forms thereof, processes for the preparation of the new salt forms; and their use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: April 2, 2024
    Assignee: CRT Pioneer Fund LP
    Inventors: Julian S. Northen, John Mykytiuk, Gillian Moore
  • CRYSTALLINE FORMS OF A TYK2 INHIBITOR
    Publication number: 20230159473
    Abstract: The invention provides crystalline forms of a compound having the formula (1): along with methods of making the crystalline forms and pharmaceutical formulations comprising the crystalline forms.
    Type: Application
    Filed: April 6, 2021
    Publication date: May 25, 2023
    Inventors: John Charles READER, Jamie Conor MARSHALL, John MYKYTIUK, Julian Scott NORTHEN
  • POLYMORPHS OF TRIAZOLE ANTIFUNGAL COMPOUND PC945
    Publication number: 20230028714
    Abstract: The invention relates to crystalline polymorphic manifestations of a compound of formula (I) and related aspects.
    Type: Application
    Filed: December 4, 2020
    Publication date: January 26, 2023
    Applicant: Pulmocide Limited
    Inventors: Christopher John WALLIS, Gerald STEELE, Suzanne BUTTAR, Osama SULEIMAN, Julian NORTHEN, John MYKYTIUK, Jamie MARSHALL
  • Salt of a pyrimido[6,1-A]isoquinolin-4-one compound
    Patent number: 11491155
    Abstract: The present invention relates to a pharmaceutically acceptable acid addition salt of: (i) 9,10-dimethoxy-2-(2,4,6-tri-methylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (RPL554); and (ii) ethane-1,2-disulfonic acid, ethanesulfonic acid, methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, hydrochloric acid, hydrobromic acid, phosphoric acid or sulfuric acid.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: November 8, 2022
    Assignee: VERONA PHARMA PLC
    Inventors: Peter Lionel Spargo, Edward James French, Julian Scott Northen, John Mykytiuk
  • CRYSTALLINE FORMS OF PYRIMIDINO DIAZEPINE DERIVATIVE
    Publication number: 20220281880
    Abstract: The present invention relates to new crystalline forms of a pyrimido-diazepine derivative which exhibits excellent anti-tumour activity. The invention also relates to a pharmaceutical composition containing said crystalline forms as an active ingredient, and use thereof in the prevention or treatment of disease. The invention further relates to a process for preparing the crystalline forms.
    Type: Application
    Filed: August 14, 2020
    Publication date: September 8, 2022
    Inventors: Benjamin SKEAD, Julian NORTHEN, Chris ATHERTON, John MYKYTIUK
  • SALT FORM
    Publication number: 20210214350
    Abstract: Ditosylate salts of N2-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine, and crystalline forms thereof; processes for the preparation of the new salt forms; and their use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer.
    Type: Application
    Filed: June 6, 2019
    Publication date: July 15, 2021
    Inventors: Julian S. Northen, John Mykytiuk, Gillian Moore
  • SALT FORM
    Publication number: 20210214351
    Abstract: Diphosphate salts of N2-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine, and crystalline forms thereof; processes for the preparation of the new salt forms; and their use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer.
    Type: Application
    Filed: June 6, 2019
    Publication date: July 15, 2021
    Inventors: Julian S. Northen, John Mykytiuk, Gillian Moore
  • SALT OF A PYRIMIDO[6,1-A]ISOQUINOLIN-4-ONE COMPOUND
    Publication number: 20200016158
    Abstract: The present invention relates to a pharmaceutically acceptable acid addition salt of: (i) 9,10-dimethoxy-2-(2,4,6-tri-methylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (RPL554); and (ii) ethane-1,2-disulfonic acid, ethanesulfonic acid, methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, hydrochloric acid, hydrobromic acid, phosphoric acid or sulfuric acid.
    Type: Application
    Filed: September 24, 2019
    Publication date: January 16, 2020
    Inventors: Peter Lionel Spargo, Edward James French, Julian Scott Northen, John Mykytiuk
  • Salt of a pyrimido[6,1-A]isoquinolin-4-one compound
    Patent number: 10463665
    Abstract: The present invention relates to a pharmaceutically acceptable acid addition salt of: (i) 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (RPL554); and (ii) ethane-1,2-disulfonic acid, ethanesulfonic acid, methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, hydrochloric acid, hydrobromic acid, phosphoric acid or sulfuric acid.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: November 5, 2019
    Assignee: VERONA PHARMA PLC
    Inventors: Peter Lionel Spargo, Edward James French, Julian Scott Northen, John Mykytiuk
  • SALT OF A PYRIMIDO[6,1-A]ISOQUINOLIN-4-ONE COMPOUND
    Publication number: 20180021337
    Abstract: The present invention relates to a pharmaceutically acceptable acid addition salt of: (i) 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (RPL554); and (ii) ethane-1,2-disulfonic acid, ethanesulfonic acid, methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, hydrochloric acid, hydrobromic acid, phosphoric acid or sulfuric acid.
    Type: Application
    Filed: February 10, 2016
    Publication date: January 25, 2018
    Inventors: Peter Lionel Spargo, Edward James French, Julian Scott Northen, John Mykytiuk
  • Polymorphs of N-[(R)-1-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-(4-ethoxy-phenyl)-ethyl]-benzamide hydrochloride
    Patent number: 9512065
    Abstract: The invention provides new polymorphs of N—[(R)-1-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-(4-ethoxy-phenyl)-ethyl]-benzamide hydrochloride, pharmaceutical compositions containing them and their use in therapy.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: December 6, 2016
    Assignee: Kalvista Pharmaceuticals Limited
    Inventors: Julian Scott Northen, John Mykytiuk
  • POLYMORPHS OF N-[(R)-1-[(S)-1-(4-AMINOMETHYL-BENZYLCARBAMOYL)-2-PHENYL-ETHYLCARBAMOYL]-2-(4-ETHOXY-PHENYL)-ETHYL]-BENZAMIDE HYDROCHLORIDE
    Publication number: 20150191421
    Abstract: The invention provides new polymorphs of N—[(R)-1-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-(4-ethoxy-phenyl)-ethyl]-benzamide hydrochloride, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: July 5, 2013
    Publication date: July 9, 2015
    Inventors: Julian Scott Northen, John Mykytiuk
  • ORGANIC COMPOUNDS
    Publication number: 20090318714
    Abstract: The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula VI, or a salt thereof, wherein R1, R2, R3 and R? are as defined in the specification, and processes of manufacturing this compound including intermediates.
    Type: Application
    Filed: November 6, 2006
    Publication date: December 24, 2009
    Inventors: John Mykytiuk, Ludovic Bonnet, Stephen Gorsuch, Osamu Ichihara, Richard Mears, Christine Richardson