Patents by Inventor John N. Feder

John N. Feder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotides encoding a novel testis-specific tubulin tyrosine-ligase-like protein, BGS42
    Patent number: 7115402
    Abstract: The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: July 9, 2003
    Date of Patent: October 3, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: John N. Feder, Shujian Wu, Thomas C. Nelson
  • Polynucleotide encoding a novel human G-protein coupled receptor variant of HM74, HGPRBMY74
    Patent number: 7094572
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY74 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY74 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: August 22, 2006
    Assignee: Bristol-Myers Squibb
    Inventors: Chandra S. Ramanathan, John N. Feder
  • Plasmids comprising nucleic acids from the hereditary hemochromatosis gene
    Patent number: 7078513
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: July 18, 2006
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • Hereditary hemochromatosis gene
    Patent number: 7067255
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: June 27, 2006
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • Polynucleotides encoding a novel glycine receptor alpha subunit expressed in the gastrointestinal tract, HGRA4, and splice variant thereof
    Patent number: 7056737
    Abstract: The present invention provides novel polynucleotides encoding HGRA4 polypeptides, fragments and homologues thereof. The present invention also provides novel polynucleotides encoding a HGRA4 splice variant, HGRA4sv. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGRA4 and HGRA4sv polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: June 6, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: John N. Feder, Liana Lee, Jian Chen, Nathan O. Siemers, Han Chang
  • Polynucleotides encoding a novel human G-protein coupled receptor splice variant HGPRBMY29sv1
    Patent number: 7049096
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: May 23, 2006
    Assignee: Bristol-Meyers Squibb Company
    Inventors: John N. Feder, Chandra S. Ramanathan, Gabriel A. Mintier, David Bol, Donald R. Hawken
  • Polynucleotides encoding novel human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1
    Patent number: 6949363
    Abstract: The present invention provides novel polynucleotides encoding HLRRBM1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRBM1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly immune diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: September 27, 2005
    Assignee: Brilstol-Myers Squibb
    Inventors: John N. Feder, Chandra S. Ramanathan, Gabriel A. Mintier
  • Peptides and peptide analogues designed from HFE protein and their uses in the treatment of iron overload diseases
    Patent number: 6924265
    Abstract: The present invention relates to peptides and peptide analogues designed from HFE protein. In particular, it relates to peptides and peptide analogues designed from an alpha-1 region of HFE protein which lowers the binding affinity of transferrin receptor for transferrin. Such compounds mimic HFE protein function, and reduce iron uptake and/or accumulation by a cell.
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: August 2, 2005
    Assignees: Bio-Rad Laboratories, Inc., California Institute of Technology
    Inventors: John N. Feder, Randall C. Schatzman, Pamela J. Bjorkman, Melanie Bennett, Jose Lebron
  • Human leucine-rich repeat containing protein expressed predominately in small intestine, HLRRSI1
    Patent number: 6858407
    Abstract: The present invention provides novel polynucleotides encoding HLRRSI1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRSI1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly gastrointestinal diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: February 22, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: John N. Feder, Chandra S. Ramanathan, Gabriel A. Mintier
  • Methods and compositions for diagnosis and treatment of iron misregulation diseases
    Patent number: 6849399
    Abstract: Methods and compositions are provided for the diagnosis and treatment of iron misregulation diseases, including HFE polypeptides, agonists, and antagonists, and transferrin receptor agonists and antagonists.
    Type: Grant
    Filed: August 27, 1997
    Date of Patent: February 1, 2005
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: John N. Feder, Randall C. Schatzman, Zenta Tsuchihashi
  • Novel human leucine-rich repeat containing protein expressed predominately in small intestine, HLRRSI1
    Publication number: 20040265890
    Abstract: The present invention provides novel polynucleotides encoding HLRRSI1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRSI1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly gastrointestinal diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: July 1, 2004
    Publication date: December 30, 2004
    Inventors: John N. Feder, Chandra S. Ramanathan, Gabriel A. Mintier
  • Novel G-protein coupled receptor (GPCR) variants and methods of use thereof
    Publication number: 20040253668
    Abstract: The present invention describes human G-protein coupled receptors (GPCRs) and their encoding polynucleotides. Also described are expression vectors, host cells, antisense molecules, and antibodies associated with the GPCR polynucleotides and/or polypeptides of this invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders or diseases associated with abnormal biological activity of GPCR are described, as are methods for screening for modulators, e.g., agonists or antagonists, of GPCR activity and/or function.
    Type: Application
    Filed: January 22, 2003
    Publication date: December 16, 2004
    Inventors: Chandra S. Ramanathan, Shuba Gopal, Gabriel Mintier, John N. Feder
  • Polynucleotide encoding a novel human P2X7 splice variant, HBMYP2X7v
    Publication number: 20040229262
    Abstract: The present invention provides novel polynucleotides encoding HBMYP2X7v polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HBMYP2X7v polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: April 2, 2004
    Publication date: November 18, 2004
    Inventors: Diana L. Franco, Chandra S. Ramanathan, Martin A. Lewis, John N. Feder
  • Polynucleotides encoding novel variants of the TRP channel family member, LTRPC3
    Publication number: 20040229315
    Abstract: The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: May 10, 2004
    Publication date: November 18, 2004
    Inventors: Ning Lee, Jian Chen, John N. Feder, Shujian Wu, Michael A. Blanar, David K. Bol, Paul C. Levesque, Lucy Sun
  • Polynucleotide encoding a novel acyl coenzyme a, monoacylglycerol acyltransferase-3 (MGAT3), and uses thereof
    Publication number: 20040223959
    Abstract: The present invention provides novel polynucleotides encoding MGAT3 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MGAT3 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as obesity. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: January 21, 2004
    Publication date: November 11, 2004
    Inventors: John N. Feder, Thomas C. Nelson, Jian Chen, Rupalie Meegalla, Michael Ramaker, Dong Cheng
  • Novel human G-protein coupled receptor, HGPRBMY8, expressed highly in brain
    Publication number: 20040214317
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, and diseases or disorders related to the brain are illustrated.
    Type: Application
    Filed: November 13, 2003
    Publication date: October 28, 2004
    Inventors: Peter Battaglino, John N. Feder, Gabriel Mintier, Thomas C. Nelson, Chandra S. Ramanathan, Ryan Westphal, Angela M. Cacace, Lauren E. Barber, Donald R. Hawken, Michael G. Kornacker
  • Polynucleotides encoding a novel human phosphatase, BMY_HPP13
    Publication number: 20040204576
    Abstract: The present invention provides novel polynucleotides encoding a human phosphatase polypeptide, BMY_HPP13, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptide. The invention further relates to diagnostic and therapeutic methods for applying this novel human phosphatase polypeptide to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: July 2, 2003
    Publication date: October 14, 2004
    Inventors: Donald Jackson, Gary L. Schieven, Stanley R. Krystek, John N. Feder, Thomas C. Nelson, Donna A. Bassolino
  • Polynucleotides encoding a novel testis-specific tubulin tyrosine-ligase-like protein, BGS42
    Publication number: 20040171131
    Abstract: The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: August 7, 2003
    Publication date: September 2, 2004
    Inventors: John N. Feder, Thomas C. Nelson, Shujian Wu, Stanley R. Krystek
  • Polynucleotides and polypeptides associated with the NF-kappaB pathway
    Publication number: 20040171823
    Abstract: The present invention relates to polynucleotide and polypeptide sequences newly identified as associated with the NF-&kgr;B pathway. The identification of such polynucleotides and polypeptides is an important advancement toward discovering and identifying new drug targets for the treatment of NF-&kgr;B pathway-related diseases, disorders, and conditions. The invention further relates to compositions and methods for the treatment of diseases or disorders associated with the NF-&kgr;B signaling pathway using the sequences of the invention.
    Type: Application
    Filed: January 13, 2004
    Publication date: September 2, 2004
    Inventors: Steven G. Nadler, Michael G. Neubauer, John N. Feder, Julie Carman
  • Novel human G-protein coupled receptor, HGPRBMY18, expressed highly in pituitary gland, colon carcinoma, and lung cancer cells
    Publication number: 20040161823
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, endocrine conditions, neurological conditions, and diseases or disorders related to the pituitary gland, colon, breast, lungs, kidney, and prostate are illustrated.
    Type: Application
    Filed: January 30, 2004
    Publication date: August 19, 2004
    Inventors: John N. Feder, Gabriel Mintier, Chandra S. Ramanathan, Donald R. Hawken