Patents by Inventor John N. Feder

John N. Feder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptides and peptide analogues designed from HFE protein and their uses in the treatment of iron overload diseases
    Patent number: 6284732
    Abstract: The present invention relates to peptides and peptide analogues designed from HFE protein. In particular, it relates to peptides and peptide analogues designed from an alpha-1 region of HFE protein which lowers the binding affinity of transferrin receptor for transferrin. Such compounds mimic HFE protein function, and reduce iron uptake and/or accumulation by a cell.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: September 4, 2001
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: John N. Feder, Randall C. Schatzman, Pamela J. Bjorkman, Melanie Bennett, Jose Lebron
  • Method for determining the presence or absence of a hereditary hemochromatosis gene mutation
    Patent number: 6228594
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also relates to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Grant
    Filed: February 14, 2000
    Date of Patent: May 8, 2001
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • Hereditary hemochromatosis gene products
    Patent number: 6140305
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: October 31, 2000
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • Hereditary hemochromatosis gene
    Patent number: 6025130
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also relates to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Grant
    Filed: May 23, 1996
    Date of Patent: February 15, 2000
    Assignee: Mercator Genetics, Inc.
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • Method to diagnose hereditary hemochromatosis
    Patent number: 5753438
    Abstract: New genetic markers for the presence of a mutation in the common hereditary hemochromatosis (HH) gene are disclosed. The multiplicity of markers permits definition of genotypes characteristic of carriers and homozygotes containing this mutation in their genomic DNA.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: May 19, 1998
    Assignee: Mercator Genetics, Inc.
    Inventors: Dennis T. Drayna, John N. Feder, Andreas Gnirke, Bruce E. Kimmel, Winston J. Thomas, Roger K. Wolff
  • Hereditary hemochromatosis diagnostic markers and diagnostic methods
    Patent number: 5712098
    Abstract: A single base-pair polymorphism involving a mutation from Guanine (G), in individuals unaffected by the hereditary hemochromatosis (HH) gene defect, to Adeninc (A), in individuals affected by the HH gene defect is disclosed. The presence or absence of the polymorphic allele is highly predictive of whether an individual is at risk from HH: the polymorphism is present in 82% of affected individuals and only 4% of a random population screen. Methods of diagnosis, markers, and primers are disclosed and claimed in accordance with the present invention.
    Type: Grant
    Filed: April 16, 1996
    Date of Patent: January 27, 1998
    Assignee: Mercator Genetics
    Inventors: Zenta Tsuchihashi, Andreas Gnirke, Winston J. Thomas, Dennis T. Drayna, David Ruddy, Roger K. Wolff, John N. Feder
  • Method to diagnose hereditary hemochromatosis
    Patent number: 5705343
    Abstract: New genetic markers for the presence of a mutation in the common hereditary hemochromatosis (HH) gene are disclosed. The multiplicity of markers permits definition of genotypes characteristic of carriers and homozygotes containing this mutation in their genomic DNA.
    Type: Grant
    Filed: February 9, 1996
    Date of Patent: January 6, 1998
    Assignee: Mercator Genetics, Inc.
    Inventors: Dennis T. Drayna, John N. Feder, Andreas Gnirke, Bruce E. Kimmel, Winston J. Thomas, Roger K. Wolff