Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

Abstract: Described herein are methods and computer systems for classification of CD8 T-cell topology using a patient response-based linear cutoff model. A plurality of histology images of tissue samples in a plurality of patients are received by a computer system. An image analysis of the plurality of histology images is performed to obtain a CD8+ T-cell abundance in the tumor parenchyma and stroma in each of the plurality of histology images. Real inflammation scores and tumor infiltration scores are determined based on a polar coordinate transformation of the CD8+ T-cell abundance in the tumor parenchyma and stroma. Based on the real inflammation scores and tumor infiltration scores, a feature space is generated, and linear boundaries or linear cutoffs between a plurality of classifications in the feature space are identified based on the real inflammation scores, the tumor infiltration scores, and patient response data.

Abstract: A carton blank is used in a form, fill and seal machine on which a closure is directly molded onto the carton. The molding portion of the machine includes a tool set having first and second tool elements in which the first tool element has an aligning member extending therefrom in a direction transverse to a direction of loading the carton between the first and second tool elements. The aligning element has a predetermined shape having diverging surfaces. The carton blank includes a rear wall panel, a first side wall panel, a front wall panel and a second side wall panel. Each panel is separated from its adjacent panels by a vertical score line. A closure panel is adjacent the front wall panel, has an opening therein and is configured for having a closure molded thereon. The closure panel is partitioned from the front wall panel by a first horizontal score line. The closure panel has a closure panel fin panel extending from a side opposite the front wall panel.

Abstract: A method and system for computer aided design (CAD) is disclosed for designing geometric objects. The present invention interpolates and/or blends between such geometric objects sufficiently fast so that real time deformation of such objects occurs while deformation data is being input. Thus, a user designing with the present invention obtains immediate feedback to input modifications without separately entering a command for performing such deformations. The present invention utilizes novel computational techniques for blending between geometric objects, wherein weighted sums of points on the geometric objects are used in deriving a new blended geometric object. The present invention is particularly useful for designing the shape of surfaces. Thus, the present invention is applicable to various design domains such as the design of, e.g., bottles, vehicles, and watercraft.

Abstract: A method and system for computer aided design (CAD) is disclosed for designing geometric objects. The present invention interpolates and/or blends between such geometric objects sufficiently fast so that real time deformation of such objects occurs while deformation data is being input. Thus, a user designing with the present invention obtains immediate feedback to input modifications without separately entering a command for performing such deformations. The present invention utilizes novel computational techniques for blending between geometric objects, wherein weighted sums of points on the geometric objects are used in deriving a new blended geometric object. The present invention is particularly useful for designing the shape of surfaces. Thus, the present invention is applicable to various design domains such as the design of, e.g., bottles, vehicles, and watercraft.

Abstract: A form, fill and seal packaging machine is configured to mold a closure directly onto a carton. The machine includes a carton erection station to receive and erect a carton and a direct injection molding station. The molding station has an internal mold tool for receipt of the carton, and an external mold tool set. The internal tool and external tool set are configured to receive and secure a portion of the carton therebetween and define a mold cavity with the portion of the carton disposed therein. The external mold tool set defines an opening for receiving a polymer injection system to inject polymer into the mold cavity. A closure is directly molded in place on the carton, with the polymer encapsulating the inner peripheral edge of the carton opening that is disposed within the mold cavity. The packaging machine also includes a filling station for filling the carton and a sealing station for forming a seal on the carton.

Abstract: A method and system for computer aided design (CAD) is disclosed for designing geometric objects. The present invention interpolates and/or blends between such geometric objects sufficiently fast so that real time deformation of such objects occurs while deformation data is being input. Thus, a user designing with the present invention obtains immediate feedback to input modifications without separately entering a command for performing such deformations. The present invention utilizes novel computational techniques for blending between geometric objects, wherein weighted sums of points on the geometric objects are used in deriving a new blended geometric object. The present invention is particularly useful for designing the shape of surfaces. Thus, the present invention is applicable to various design domains such as the design of, e.g., bottles, vehicles, and watercraft.

Abstract: A method and system for computer aided design (CAD) is disclosed for designing geometric objects. The present invention interpolates and/or blends between such geometric objects sufficiently fast so that real time deformation of such objects occurs while deformation data is being input. Thus, a user designing with the present invention obtains immediate feedback to input modifications without separately entering a command for performing such deformations. The present invention utilizes novel computational techniques for blending between geometric objects, wherein weighted sums of points on the geometric objects are used in deriving a new blended geometric object. The present invention is particularly useful for designing the shape of surfaces. Thus, the present invention is applicable to various design domains such as the design of, e.g., bottles, vehicles, and watercraft.

Abstract: A transfer unit is configured for use with a form, fill and seal packaging machine. The transfer unit receives a partially erected carton from a first station in a tubular form, conveys the carton to a second station, and conveys the carton from the second station to a third station. The transfer unit includes a hub defining a longitudinal hub axis and configured for rotational movement about the hub axis. A plurality of car pairs are mounted to the hub for longitudinal movement along the hub. Each of the car pairs includes first and second cars, each of which has first and second mandrels mounted thereto. The mandrels are configured to receive a partially erected carton. Each mandrel has a mandrel axis and is rotational about its respective axis. The mandrel axes are perpendicular and tangential to the hub axis.

Abstract: A transfer unit is configured for use with a form, fill and seal packaging machine. The transfer unit receives a partially erected carton from a first station in a tubular form, conveys the carton to a second station, and conveys the carton from the second station to a third station. The transfer unit includes a hub defining a longitudinal hub axis and configured for rotational movement about the hub axis. A plurality of car pairs are mounted to the hub for longitudinal movement along the hub. Each of the car pairs includes first and second cars, each of which has first and second mandrels mounted thereto. The mandrels are configured to receive a partially erected carton. Each mandrel has a mandrel axis and is rotational about its respective axis. The mandrel axes are perpendicular and tangential to the hub axis.

Abstract: A transfer unit is configured for use with a form, fill and seal packaging machine. The transfer unit receives a partially erected carton from a first station in a tubular form, conveys the carton to a second station, and conveys the carton from the second station to a third station. The transfer unit includes a hub defining a longitudinal hub axis and configured for rotational movement about the hub axis. A plurality of car pairs are mounted to the hub for longitudinal movement along the hub. Each of the car pairs includes first and second cars, each of which has first and second mandrels mounted thereto. The mandrels are configured to receive a partially erected carton. Each mandrel has a mandrel axis and is rotational about its respective axis. The mandrel axes are perpendicular and tangential to the hub axis.

Abstract: A light beam encoded with data simultaneously reads out data stored in tracks on an optical disk and produces a reflected beam directed to a detector array. The data stored on the optical disk and the encoded data may be components of vector arrays. As the light beam illuminates the rotating optical disk, the data stored on the disk is multiplied by the encoded data. The products of the multiplication are encoded in the reflected beam. A multiplicity of data is read out in parallel from the optical disk and simultaneously correlated with the encoded data. This comparison or correlation operation is performed on digitally encoded data utilizing convolution, or with analog encoding. The present invention can be utilized in pattern matching.

Abstract: A light beam encoded with data simultaneously reads out data stored in tracks on an optical disk and produces a reflected beam directed to a detector array. The data stored on the optical disk and the encoded data may be components of vector arrays. As the light beam illuminates the rotating optical disk, the data stored on the disk is multiplied by the encoded data. The products of the multiplication are encoded in the reflected beam. A multiplicity of data is read out in parallel from the optical disk and simultaneously correlated with the encoded data. This comparison or correlation operation is performed on digitally encoded data utilizing convolution, or with analog encoding. The present invention can be utilized in pattern matching.

Abstract: A method and system for computer aided design (CAD) is disclosed for designing geometric objects. The present invention interpolates and/or blends between such geometric objects sufficiently fast so that real time deformation of such objects occurs while deformation data is being input. Thus, a user designing with the present invention obtains immediate feedback to input modifications without separately entering a command for performing such deformations. The present invention utilizes novel computational techniques for blending between geometric objects, wherein weighted sums of points on the geometric objects are used in deriving a new blended geometric object. The present invention is particularly useful for designing the shape of surfaces. Thus, the present invention is applicable to various design domains such as the design of, e.g., bottles, vehicles, and watercraft.

Abstract: A light beam encoded with data simultaneously reads out data stored in tracks on an optical disk and produces a reflected beam directed to a detector array. The data stored on the optical disk and the encoded data may be components of vector arrays. As the light beam illuminates the rotating optical disk, the data stored on the disk is multiplied by the encoded data. The products of the multiplication are encoded in the reflected beam. A multiplicity of data is read out in parallel from the optical disk and simultaneously correlated with the encoded data. This comparison or correlation operation is performed on digitally encoded data utilizing convolution, or with analog encoding. The present invention can be utilized in pattern matching.

Abstract: A light beam encoded with data simultaneously reads out data stored in tracks on an optical disk and produces a reflected beam directed to a detector array. The data stored on the optical disk and the encoded data may be components of vector arrays. As the light beam illuminates the rotating optical disk, the data stored on the disk is multiplied by the encoded data. The products of the multiplication are encoded in the reflected beam. A multiplicity of data is read out in parallel from the optical disk and simultaneously correlated with the encoded data. This comparison or correlation operation is performed on digitally encoded data utilizing convolution, or with analog encoding. The present invention can be utilized in pattern matching.

Abstract: A light beam encoded with data simultaneously reads out data stored in tracks on an optical disk and produces a reflected beam directed to a detector array. The data stored on the optical disk and the encoded data may be components of vector arrays. As the light beam illuminates the rotating optical disk, the data stored on the disk is multiplied by the encoded data. The products of the multiplication are encoded in the reflected beam. A multiplicity of data is read out in parallel from the optical disk and simultaneously correlated with the encoded data. This comparison or correlation operation is performed on digitally encoded data utilizing convolution, or with analog encoding. The present invention can be utilized in pattern matching.

Abstract: A light beam encoded with data simultaneously reads out data stored in tracks on an optical disk and produces a reflected beam directed to a detector array. The data stored on the optical disk and the encoded data may be components of vector arrays. As the light beam illuminates the rotating optical disk, the data stored on the disk is multiplied by the encoded data. The products of the multiplication are encoded in the reflected beam. A multiplicity of data is read out in parallel from the optical disk and simultaneously correlated with the encoded data. This comparison or correlation operation is performed on digitally encoded data utilizing convolution, or with analog encoding. The present invention can be utilized in pattern matching.

Abstract: A gas supply system connected to vent a tank of a product filling system is set forth. The gas supply system comprises a high pressure/low pressure gas supply having a common outlet. The high pressure/low pressure gas supply is operable in a first mode of operation in which high pressure gas is supplied at the common outlet and a second mode of operation in which low pressure gas is supplied at the common outlet. A sterile filter having an inlet and an outlet is also provided. A steam supply system is disposed in-line between the common outlet of the high pressure/low pressure gas supply and the sterile filter. A tank valve system is provided having an inlet in fluid communication with the outlet of the sterile filter. The tank valve system also has first and second outlets and is operable in a first mode of operation in which the inlet is placed in fluid communication with the first outlet and a second mode of operation in which the inlet is placed in fluid communication with the second outlet.

Abstract: A carton filling machine comprising a compartmentalized clean air system for providing a downward unidirectional flow of clean air into a chamber that substantially encloses one of the machine stations is provided. Preferably, the machine station is a filling station. Even more preferably the clean air system encloses both the fill pipe of the filling station and a top folding portion of a top sealing station of the machine. The top folding portion of the top sealing station ensures that the carton exits the chamber in a closed state whereby the carton is maintained in a very hygienic state after it has been filled in a very hygienic atmosphere. The air flow is advantageously divided into plural streams, one of which is directed about the fill pipe to further ensure sterile filling conditions.