Patents by Inventor John Neilan

John Neilan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10772994
    Abstract: A medical device such as a stent (10) or medical balloon (40) is functionalised prior to coating with a bioactive material (54), specifically by acidification or basification of the contact surface or surfaces (50) of the medical device. Functionalisation with subsequent coating of bioactive agent directly onto the functionalised surface provides a significantly more consistent and reliable coating of bioactive agent on a medical device without requiring containment or time release devices.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: September 15, 2020
    Assignee: Cook Medical Technologies LLC
    Inventors: John Neilan, David Murray, James Butler
  • Publication number: 20200170814
    Abstract: A medical device such as a stent or medical balloon is functionalised prior to coating with a bioactive material, specifically by carboxylic acidification of the contact surface or surfaces of the medical device. The preferred process involves washing a stent or other medical device in a washing solution which may be sodium hydroxide, soaking in a carboxylic acid solution, rinsing in water to remove excess carboxylic acid, allowing to dry before applying a bioactive agent layer. It has been found that washing after functionalisation removes excess carboxylic acid and enhances the retention of bioactive agent on the contact surface or surfaces of the medical device leading to a more uniform and consistent layer of bioactive agent.
    Type: Application
    Filed: November 29, 2018
    Publication date: June 4, 2020
    Inventors: John Neilan, David Murray, James Butler
  • Publication number: 20200138610
    Abstract: A stent may include a tubular stent body having a lumen extending therethrough. The stent may further include an anchor portion attached to an end of the tubular stent body, where the lumen continues through the anchor portion, and where the anchor portion includes at least one opening configured to facilitate tissue ingrowth. The anchor portion may be detachable from the tubular stent body while the stent is in a deployed state.
    Type: Application
    Filed: July 17, 2019
    Publication date: May 7, 2020
    Applicant: Cook Medical Technologies LLC
    Inventors: Gerard Treacy, John Neilan
  • Patent number: 10604548
    Abstract: This application is directed generally to minicircle DNA vectors for the vaccination of foot-and-mouth disease (FMD). The transgene expression cassette in the minicircle DNA vector includes: a eukaryotic translation initiation nucleotide sequence, a mutant nucleotide sequence that encodes a foot-and-mouth disease virus (FMDV) capsid polyprotein precursor that contains at least one mutation to eliminate a restriction enzyme recognition site, a nucleotide sequence that encodes a protease that cleaves the MEW capsid polyprotein precursor into plurality of FMDV capsid proteins and a translational regulatory element to regulate the expression of the protease. The minicircle DNA vectors can be transfected directly into the cell of a mammalian host. When transfected into the mammalian host cell, virus-like particles can be produced intrinsically to stimulate the mammalian host's immune system to develop adaptive immunity toward foot-and-mouth disease.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: March 31, 2020
    Assignee: The Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventors: Michael Puckette, Max Rasmussen, John Neilan
  • Publication number: 20200016299
    Abstract: A medical device such as a stent (10) or medical balloon (40) is at least partially coated with a saturated carboxylic acid layer in order to enhance biocompatibility, reduce thrombogenesis and increase endothelialisation. The coating is preferably of citric acid in non-crosslinked form and preferably non-porous so as to mask the underlying structure of the medical device. The acid coating forms an outer surface of at least a part of the medical device, that is has no other layer or material overlying it, save for in some embodiments a partial coating of a bioactive material.
    Type: Application
    Filed: July 12, 2019
    Publication date: January 16, 2020
    Inventors: John Neilan, David Murray, James Butler
  • Publication number: 20200016298
    Abstract: A medical device such as a stent (10) or medical balloon (40) is at least partially coated with a carboxylic acid layer in order to enhance biocompatibility, reduce thrombogenesis and increase endothelialisation. The coating is preferably of citric acid in non-crosslinked form and preferably non-porous so as to mask the underlying structure of the medical device. The acid coating forms an outer surface of at least a part of the medical device, that is has no other layer or material overlying it, save for in some embodiments a partial coating of a bioactive material.
    Type: Application
    Filed: July 12, 2018
    Publication date: January 16, 2020
    Inventors: John Neilan, David Murray, James Butler
  • Patent number: 10513542
    Abstract: This application is directed generally to minicircle DNA vectors for the vaccination of foot-and-mouth disease (FMD). The transgene expression cassette in the minicircle DNA vector includes: a eukaryotic translation initiation nucleotide sequence, a mutant nucleotide sequence that encodes a foot-and-mouth disease virus (FMDV) capsid polyprotein precursor that contains at least one mutation to eliminate a restriction enzyme recognition site, a nucleotide sequence that encodes a protease that cleaves the FMDV capsid polyprotein precursor into a plurality of FMDV capsid proteins and a translational regulatory element to regulate the expression of the protease. The minicircle DNA vectors can be transfected directly into the cell of a mammalian host. When transfected into the mammalian host cell, virus-like particles can be produced intrinsically to stimulate the mammalian host's immune system to develop adaptive immunity toward foot-and-mouth disease.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: December 24, 2019
    Assignee: The Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventors: Michael Puckette, Max Rasmussen, John Neilan
  • Publication number: 20190365363
    Abstract: The present disclosure relates generally to systems and kits for the retrieval of samples from a biopsy needle and to methods of using such devices. In one embodiment, components of the system are supplied in the form of a kit contained in packaging that is utilized during the retrieval of the sample.
    Type: Application
    Filed: May 22, 2019
    Publication date: December 5, 2019
    Applicant: COOK MEDICAL TECHNOLOGIES LLC
    Inventors: Rory O'Callaghan, Michael S. Clancy, John Neilan, Patrick Dennis
  • Publication number: 20190359964
    Abstract: The disclosure is directed to an isolated polynucleotide encoding a modified picornavirus 3C protease, wherein the modified picornavirus 3C protease includes an altered secondary structure and one or more amino acid substitution(s) located at one or more amino acid position(s) corresponding to positions 16-25, 99-100 and 115-130 of a wild-type Fool-and-Mouth Disease Virus (FMDV) 3C protease, wherein the isolated polynucleotide encoding the modified picornavirus 3C protease, when transformed into and co-expressed in a host cell, enhances transgene expression of a P1 precursor polypeptide in comparison to an amount of P1 precursor polypeptide transgene expression exhibited in a host cell transformed and co-expressed with a control picornavirus 3C protease, wherein the one or more corresponding amino acid position(s) is/are identified by an alignment of the modified picornavirus 3C protease with the one or more of the wild type FMDV 3C protease(s).
    Type: Application
    Filed: May 22, 2018
    Publication date: November 28, 2019
    Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Securit
    Inventors: Michael Puckette, John Neilan
  • Patent number: 10369030
    Abstract: A stent and method for treating an end of a pre-woven stent is provided. The method includes providing a pre-woven stent including a plurality of sharp ends. A pair of wire portions that extend in opposite helical directions around the stent are bent and woven into the stent to define a pair of overlapping crown portions. When the wires are woven into the stent a double weave portion of the stent is defined. The wires can be cut to define tail portions that are removed from the stent, leaving a single crown portion. The sharp ends can be alternatively treated by curving the ends to define rounded looped ends.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: August 6, 2019
    Assignee: Cook Medical Technologies LLC
    Inventors: Gerard Thomas Treacy, Don Frawley, John Neilan
  • Publication number: 20190175221
    Abstract: A single-wire stylet may be constructed as an elongate single-wire, memory-metal alloy body with a generally cylindrical body profile, extending distally from a proximal end terminus, where embodiments include a polymeric distal tip member fixedly attached directly at a distal end of the single-wire body. At least one lengthwise portion of the single-wire body is at least partially in martensitic phase at operating temperatures at and below about 37° C. Where present, the polymeric distal tip member has a generally cylindrical body profile circumferentially bounded by an outer circumference substantially equal to or greater than that of the metal body. The polymeric distal tip member may be overmolded upon a distal-end tip length of an elongate single-wire, memory-metal alloy stylet body, where the distal end and/or discrete intermediate distal-portion length(s) that include martensitic-phase alloy and any polymeric member have greater flexibility than a proximal-most length of the alloy stylet body.
    Type: Application
    Filed: February 14, 2019
    Publication date: June 13, 2019
    Applicant: Cook Medical Technologies LLC
    Inventors: Fionán Keady, John Neilan, James Butler, Shay Joseph Lavelle
  • Publication number: 20190161854
    Abstract: A method of modifying a surface of a medical device for implantation or disposition inside a patient is described. The medical device comprises a structure having at least one surface. The method includes the steps of: placing the medical device into a plasma chamber substantially free from contaminants and substantially sealing the plasma chamber from the atmosphere; removing at least an outermost layer of any oxide layer from the at least one surface of the structure by a plasma oxide-removal process, whilst maintaining the plasma chamber under seal from the atmosphere; and subsequently forming a new oxide layer at the least one surface of the structure by introducing at least one gas into the plasma chamber, whilst maintaining the plasma chamber under seal from the atmosphere. A medical device including a bulk material and an oxide layer disposed over at least one surface of the medical device. The oxide layer is substantially pure and free from contaminants.
    Type: Application
    Filed: November 27, 2018
    Publication date: May 30, 2019
    Inventors: John Neilan, David Murray, James Butler
  • Publication number: 20190159879
    Abstract: A prosthesis and a method of manufacturing the prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough. The prosthesis also includes a valve operably connected to the body. The valve has a proximal portion, a distal portion and a lumen extending through the valve, where the valve lumen is connected to the body lumen. The valve is configured to be closed in the absence of an antegrade pressure and a retrograde pressure, the retrograde pressure being greater than the antegrade pressure. The valve includes a material portion operably connected to the valve, the material portion providing increased stiffness to the valve relative to the valve alone, wherein the material portion is configured to facilitate self-reversion of the valve to the closed configuration.
    Type: Application
    Filed: February 1, 2019
    Publication date: May 30, 2019
    Applicant: Cook Medical Technologies LLC
    Inventors: Alison Liddy, Michael Ryan, Gerard Treacy, Ger Houlihan, Shay Lavelle, John Neilan
  • Patent number: 10247661
    Abstract: The present invention generally relates to methods for determining the presence and distribution of a polarization active material present in a coating. In one embodiment, the coating is present on an implantable device, for example an implantable stent.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: April 2, 2019
    Assignee: COOK MEDICAL TECHNOLOGIES LLC
    Inventors: John Neilan, Syed A. M. Tofail, Rabah Mouras, Christophe Silien, Aladin Mani, David Murray
  • Patent number: 10231819
    Abstract: A prosthesis and a method of manufacturing the prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough. The prosthesis also includes a valve operably connected to the body. The valve has a proximal portion, a distal portion and a lumen extending through the valve, where the valve lumen is connected to the body lumen. The valve is configured to be closed in the absence of an antegrade pressure and a retrograde pressure, the retrograde pressure being greater than the antegrade pressure. The valve includes a material portion operably connected to the valve, the material portion providing increased stiffness to the valve relative to the valve alone, wherein the material portion is configured to facilitate self-reversion of the valve to the closed configuration.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: March 19, 2019
    Assignee: Cook Medical Technologies LLC
    Inventors: Alison Liddy, Michael Ryan, Gerard Treacy, Ger Houlihan, Shay Lavelle, John Neilan
  • Patent number: 10226279
    Abstract: A single-wire stylet may be constructed as an elongate single-wire, memory-metal alloy body with a generally cylindrical body profile, extending distally from a proximal end terminus, where embodiments include a polymeric distal tip member fixedly attached directly at a distal end of the single-wire body. At least one lengthwise portion of the single-wire body is at least partially in martensitic phase at operating temperatures at and below about 37° C. Where present, the polymeric distal tip member has a generally cylindrical body profile circumferentially bounded by an outer circumference substantially equal to or greater than that of the metal body. The polymeric distal tip member may be overmolded upon a distal-end tip length of an elongate single-wire, memory-metal alloy stylet body, where the distal end and/or discrete intermediate distal-portion length(s) that include martensitic-phase alloy and any polymeric member have greater flexibility than a proximal-most length of the alloy stylet body.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: March 12, 2019
    Assignee: Cook Medical Technologies LLC
    Inventors: Fionán Keady, John Neilan, James Butler, Shay Joseph Lavelle
  • Publication number: 20190022285
    Abstract: A medical device such as a stent (10) or medical balloon (40) is functionalised prior to coating with a bioactive material (54), specifically by acidification or basification the contact surface or surfaces (50) of the medical device. Functionalisation with subsequent coating of bioactive agent directly onto the functionalised surface provides a significantly more consistent and reliable coating of bioactive agent on a medical device without requiring containment or time release devices.
    Type: Application
    Filed: July 18, 2017
    Publication date: January 24, 2019
    Inventors: John Neilan, David Murray, James Butler
  • Publication number: 20180271682
    Abstract: A stent and method for treating an end of a pre-woven stent is provided. The method includes providing a pre-woven stent including a plurality of sharp ends. A pair of wire portions that extend in opposite helical directions around the stent are bent and woven into the stent to define a pair of overlapping crown portions. When the wires are woven into the stent a double weave portion of the stent is defined. The wires can be cut to define tail portions that are removed from the stent, leaving a single crown portion. The sharp ends can be alternatively treated by curving the ends to define rounded looped ends.
    Type: Application
    Filed: May 30, 2018
    Publication date: September 27, 2018
    Inventors: Gerard Thomas Treacy, Don Frawley, John Neilan
  • Publication number: 20180244728
    Abstract: This application is directed generally to minicircle DNA vectors for the vaccination of foot-and-mouth disease (FMD). The transgene expression cassette in the minicircle DNA vector includes: a eukaryotic translation initiation nucleotide sequence, a mutant nucleotide sequence that encodes a foot-and-mouth disease virus (FMDV) capsid polyprotein precursor that contains at least one mutation to eliminate a restriction enzyme recognition site, a nucleotide sequence that encodes a protease that cleaves the FMDV capsid polyprotein precursor into a plurality of FMDV capsid proteins and a translational regulatory element to regulate the expression of the protease. The minicircle DNA vectors can be transfected directly into the cell of a mammalian host. When transfected into the mammalian host cell, virus-like particles can be produced intrinsically to stimulate the mammalian host's immune system to develop adaptive immunity toward foot-and-mouth disease.
    Type: Application
    Filed: April 19, 2018
    Publication date: August 30, 2018
    Applicant: The Government of the United States of America, as Represented by the Secretary, Department of
    Inventors: Michael Puckette, Max Rasmussen, John Neilan
  • Publication number: 20180236143
    Abstract: There is disclosed a method of improving the reliability of coating an implantable medical device, such as a stent, with bioactive material in the absence of a carrier material such as a matrix or polymer layer. The method involves cleaning volatile components from the exposed surfaces of the medical device, removing carbon deposits and then applying a uniform carbon layer in a controlled environment. The deliberately applied carbon layer masks impurities of the underlying native oxide layer and leads to more uniform bioactive material coating not only a over the surfaces of a single medical device but also from device to device within a batch and between batches of devices. This improves production as well as optimising the amount and release of drug on the medical device without the need for a carrier material.
    Type: Application
    Filed: February 20, 2018
    Publication date: August 23, 2018
    Inventors: John Neilan, David Murray, James Butler