Patents by Inventor John Nguyen
John Nguyen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240131269Abstract: Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes a cartridge including a piston slidably disposed within an interior for delivering medicament within the interior through an outlet, and a driver including a plunger coupled to the piston, a source of pressurized fluid, and an actuator member for opening a flow path at least partially between the source and the plunger to advance the plunger and piston to deliver medicament from the interior. One or more sensors are operatively coupled to the plunger to measure displacement of the plunger, a processor is coupled to the sensor(s) for analyzing sensor signals to measure volume of medicament delivered from the interior, and an output device, e.g., one or more LEDs or speakers, provide outputs related to the volume of medicament delivered.Type: ApplicationFiled: August 27, 2023Publication date: April 25, 2024Inventors: John C. Huculak, Jack R. Auld, Hien Nguyen, Tammo Heeren, Matthew McCawley, Eric Anderfaas, John C. Dunne, JR.
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Patent number: 11964989Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.Type: GrantFiled: July 20, 2022Date of Patent: April 23, 2024Assignees: Mirati Therapeutics, Inc., Array BioPharma Inc.Inventors: Xiaolun Wang, Aaron Craig Burns, James Gail Christensen, John Michael Ketcham, John David Lawson, Matthew Arnold Marx, Christopher Ronald Smith, Shelley Allen, James F. Blake, Mark Joseph Chicarelli, Joshua Ryan Dahlke, Donghua Dai, Jay Bradford Fell, John Peter Fischer, Macedonio J. Mejia, Brad Newhouse, Phong Nguyen, Jacob Matthew O'Leary, Spencer Pajk, Martha E. Rodriguez, Pavel Savechenkov, Tony P. Tang, Guy P.A. Vigers, Qian Zhao, Dean Russell Kahn, John Gaudino, Michael Christopher Hilton
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Publication number: 20240122773Abstract: A system for managing female incontinence includes a body of biocompatible material configured to fit between the labia minora and the vestibule floor, the body having a surface configured to occlude the urethral meatus, a first adhesive layer disposed on at least a first portion of the surface and configured to provide a sealing engagement between the body and the urethral meatus, and a second adhesive layer disposed over the first adhesive layer and configured to provide a sealing engagement between the body and the urethral meatus, wherein the second adhesive layer is removable from the first adhesive layer.Type: ApplicationFiled: May 12, 2023Publication date: April 18, 2024Inventors: John Nguyen, John M. Taylor, Thomas J. Berryman
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Publication number: 20240122536Abstract: A method for using saliva to measure at least one substance or physiological parameter of a human or animal subject may involve inserting a first end of a sensor into a handheld saliva testing device. The method may also involve receiving saliva from the subject on a second end of the sensor, moving the saliva from the second end of the sensor to the first end, and processing the saliva with the handheld saliva testing device to provide initial saliva data related to the at least one substance or physiological parameter of the subject. In some embodiments, the sensor remains inserted in the handheld device while the subject deposits saliva on the opposite, free end of the sensor.Type: ApplicationFiled: May 24, 2023Publication date: April 18, 2024Inventors: Efstratios Skafidas, Chathurika Darshani Abeyrathne, Gursharan Chana, Duc Hau Huynh, Trevor John Kilpatrick, Alan D. Luther, Michael Luther, Phuong Duc Nguyen, Thanh Cong Nguyen
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Publication number: 20240108212Abstract: The eye imaging system for producing images with reduced speckle artifacts may comprise a laser diode for providing a beam of radiation to the eye; a detector for collecting light returning from the eye and generating output signals in response thereto, the detector having a sensor integration time; a driver circuit for applying a modulated drive signal to the laser diode, the modulated drive signal inducing a spectral broadening of the beam of radiation during the sensor integration time. The laser diode may be a single-mode laser designed to operate at a fixed current and wavelength. The drive signal may be modulated by shaping a drive current pulse. The drive signal may be modulated by imposing an RF modulation on a drive current pulse. The drive signal may be further modulated by shaping a drive current pulse.Type: ApplicationFiled: September 21, 2023Publication date: April 4, 2024Applicant: Carl Zeiss Meditec, Inc.Inventors: Conor Leahy, An-Dien Nguyen, Robert Sprowl, Jochen Straub, John Walker
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Publication number: 20240109611Abstract: Air deflector device for a vehicle, including: an air deflector portion configured to deflect an air flow occurring due to a movement of the vehicle, whereby the air deflector portion is further configured to be moved between a closed position and an opened position, whereby the air flow occurring due to a movement of the vehicle is pushing the air deflector portion from its opened position in its closed position; a locking mechanism configured to be moved between an unlocked position and a locked position; and/or a mounting mechanism including a force element configured to apply a force pushing the air deflector portion from its opened position in its closed position; and an actuation mechanism configured to push the air deflector portion from its closed position in its opened position.Type: ApplicationFiled: August 29, 2023Publication date: April 4, 2024Inventors: Anders Bengtsson, Tobias Johansson, John Bresner, Utpal Sharma, Leo Nguyen
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Patent number: 11944834Abstract: An external controller assembly for a medical device implanted in a patient includes an external controller and an external driveline assembly. The external controller includes an external controller display viewable by the patient. The external driveline assembly includes an external driveline cable and an external driveline distal connector. The external driveline cable is connected to the external driveline distal connector and the external controller. The external driveline cable accommodates positioning of the external driveline distal connector, by the patient, for simultaneous viewing of the external driveline distal connector and the external controller display by the patient. The external driveline distal connector is adapted to be connected to the distal driveline proximal connector by the patient. The external driveline distal connector is adapted to be disconnected from the distal driveline proximal connector by the patient.Type: GrantFiled: June 10, 2022Date of Patent: April 2, 2024Assignee: TC1 LLCInventors: John Nguyen, Fabian Franco, Mark Di Paola, Carine Hoarau, Nathan Harold, Michael Morado
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Publication number: 20240099892Abstract: An apparatus includes a shaft, an expandable dilator, and at least one ventilation pathway. The shaft defines a longitudinal axis and includes a distal and proximal ends with at least one shaft lumen. The expandable dilator includes body with its own proximal and distal ends. The body is configured to transition between a contracted state and an expanded state. The body is configured to dilate a Eustachian tube of a patient in the expanded state. The at least one ventilation pathway is configured to provide ventilation from the distal end of the body to the proximal end of the body when the body is in the expanded state. In some examples, the ventilation pathway includes a set of transversely oriented vent openings formed through the shaft. In some other examples, the ventilation pathway includes a space defined between one or more radially outwardly protruding features of the expandable dilator.Type: ApplicationFiled: October 27, 2023Publication date: March 28, 2024Inventors: Peter F. Campbell, Daniel T. Harfe, Hung V. Ha, Ketan P. Muni, Andy Nguyen, Sivette Lam, John Y. Chang, Eric Goldfarb
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Patent number: 11940227Abstract: A cooling system includes a heat exchanger having one or more rows of multiple flat tubes, louvered fins disposed between pairs of flat tubes, and special header tube connections to form a counter flow heat exchanger. Heat exchangers having multiple rows may be placed near or close to the server racks and may be in fluid communication with an outdoor heat exchanger having one or more rows. A single-phase fluid is pumped through a fluid circuit or loop, which includes the heat exchangers at the server racks and the outdoor heat exchanger. The single-phase fluid circuit including the heat exchangers at the IT racks may alternatively be in thermal communication with a water circuit that includes an outdoor fluid cooler. The flat tubes can be formed tubes with one or more channels, or extruded tubes with multiple channels. The heat exchangers include header tubes/connections, which facilitate easy fabrication and connection between rows and inlet/outlet, and lower the pressure drop.Type: GrantFiled: July 1, 2022Date of Patent: March 26, 2024Assignee: INERTECH IP LLCInventors: Ming Zhang, Ken Nguyen, Doron Shapiro, John Costakis
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Publication number: 20240092746Abstract: Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.Type: ApplicationFiled: February 13, 2023Publication date: March 21, 2024Inventors: Julio Cesar MEDINA, Alok NERURKAR, Corinne SADLOWSKI, Frederick SEIDL, Heng CHENG, Jason DUQUETTE, John LEE, Martin HOLAN, Pingyu DING, Xiaodong WANG, Tien WIDJAJA, Thomas NGUYEN, Ulhas BHATT, Yihong LI, Zhi-liang WEI
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Publication number: 20240089325Abstract: A technique is provided for determining a loss risk assessment score for a vehicle trip. The technique includes, at a vehicle, a computing device receiving first information indicative of operation of the vehicle. The technique also includes, at the vehicle, the computing device receiving second information indicative of an environment at a particular location and time. The computing device correlates the first information and the second information to generate a data set. The technique also includes determining a score for the vehicle trip based at least in part upon the generated data set.Type: ApplicationFiled: November 14, 2023Publication date: March 14, 2024Inventors: Krishna Nemmani, Zebediah Robert Black, Corey Casmedes, Hoang Dang, Yuncheng Gao, Tyler Hargreaves, John Steven Kirtzic, Zongzhe Li, Einar Longva, Victor Mao, Trac Nguyen, Sivarama Kirshna Panguluri, Dalton Sherer, Edward Yang
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Publication number: 20240079089Abstract: Systems and methods for prediction of the treatment outcome for immune therapy are presented in which omics data of a patient tumor sample are used. Most typically, the omics data are processed to identify mutational signatures (especially APOBEC/POLE signatures), immune checkpoint expression, and MSI status as leading indicators to predict the treatment outcome for immune therapy. Such prediction advantageously integrates various parameters that would otherwise, when individually considered, skew prediction outcome.Type: ApplicationFiled: November 10, 2023Publication date: March 7, 2024Inventors: Andrew Nguyen, John Zachary Sanborn, Shahrooz Rabizadeh
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Publication number: 20240078339Abstract: Communications where one or more of the participants are at least partially anonymized. For example, various embodiments allow for the hiding of facial features, the distortion of voice characteristics, or both, while still allowing substantive communication.Type: ApplicationFiled: September 1, 2023Publication date: March 7, 2024Inventors: Ronald Steven Suskind, John Nguyen
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Publication number: 20240079108Abstract: Disclosed herein are methods of identifying homologous recombination deficiency (HRD) in omics data, comprising generating a mutational spectrum from omics data; and using the mutational spectrum in a trained model to identify HRD. Further disclosed herein are methods of treating a tumor that has HRD score indicating significant HRD events, comprising: obtaining omics data from a tumor sample and generating a mutational spectrum from omics data; using the mutational spectrum in a trained model to identify HRD in the omics data from the tumor sample; identifying the cancer as likely responsive to treatment with a PARP inhibitor upon determination of HRD; and administering a PARP inhibitor treatment for the tumor upon determination of a high HRD score.Type: ApplicationFiled: October 6, 2020Publication date: March 7, 2024Inventors: Andrew Nguyen, John Zachary Sanborn, Lucy De Jong, Stephen Charles Benz
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Patent number: 11898546Abstract: A tubing assembly is provided that can comprise a plurality of tubes or lumens that can be disposed within a head of a peristaltic pump. The tubing assembly can provide a flow rate or volume capacity that is generally equal to or greater than that achieved with a comparable prior art tube while operating at higher pressures than that possible using the prior art tube. Further, in accordance with some embodiments, the tubing assembly can achieve a longer working life than a comparable prior art tube, and the load on the pump motor can be reduced such that the pump life is increased and/or a larger pump motor is not required to achieve such advantageous results.Type: GrantFiled: January 12, 2023Date of Patent: February 13, 2024Assignee: Blue-White Industries, Ltd.Inventors: Robert Gledhill, III, John Nguyen, Steven Lee Smith
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Publication number: 20240041485Abstract: Methods and apparatus for evaluating and manipulating objects in a body, for example emboli in a body lumen are described, and in some examples methods and apparatus use adaptable tips on catheters, for example aspiration catheters, for manipulating and/or removing such emboli.Type: ApplicationFiled: October 12, 2023Publication date: February 8, 2024Applicant: Q'APEL MEDICAL, INC.Inventors: TREVOR HORI, JEFFERY KROLIK, EDSEL SAN DIEGO, JOHN NGUYEN
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Patent number: 11891989Abstract: A diaphragm pump assembly can include a pump drive chamber, a first pump diaphragm chamber, and a second pump diaphragm chamber. The assembly can include a pump motor configured to rotate a motor shaft extending into the pump drive chamber. The assembly can include a cam connected to the motor shaft and configured to rotate in response to rotation of the motor shaft. The assembly can include a drive yoke having a yoke frame and a yoke pocket having a first wall and a second wall parallel and opposite the first wall. First and second pistons can connect to the drive yoke and to first and second diaphragms, respectively. The diameter of the cam can be less than and within 5% the width of yoke pocket and the yoke can be configured to move the pistons along a straight line.Type: GrantFiled: November 11, 2021Date of Patent: February 6, 2024Assignee: Blue-White Industries, Ltd.Inventors: Robert E. Gledhill, III, John Nguyen
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Publication number: 20230358222Abstract: A tubing assembly is provided that can comprise a plurality of tubes or lumens that can be disposed within a head of a peristaltic pump. The tubing assembly can provide a flow rate or volume capacity that is generally equal to or greater than that achieved with a comparable prior art tube while operating at higher pressures than that possible using the prior art tube. Further, in accordance with some embodiments, the tubing assembly can achieve a longer working life than a comparable prior art tube, and the load on the pump motor can be reduced such that the pump life is increased and/or a larger pump motor is not required to achieve such advantageous results.Type: ApplicationFiled: January 12, 2023Publication date: November 9, 2023Inventors: Robert Gledhill, III, John Nguyen, Steven Lee Smith
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Patent number: 11768092Abstract: A flow rate assembly can include a housing having a measurement channel extending along the housing axis and through a portion of the housing between the first and second ends of the housing, an outer cup portion positioned at least partly within the housing, and a transducer positioned within the outer cup portion and sealed from fluid flow past the outer cup portion, the transducer having a width perpendicular to the housing axis and greater than the width of the measurement channel, the transducer configured to generate an ultrasonic signal and to direct the ultrasonic signal through the measurement channel.Type: GrantFiled: October 18, 2021Date of Patent: September 26, 2023Assignee: Blue-White Industries, Ltd.Inventors: Robert Gledhill, III, John Nguyen, Patrick M. Murphy, William M. McDowell
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Patent number: 11684521Abstract: A system for managing female incontinence includes a body of biocompatible material configured to fit between the labia minora and the vestibule floor, the body having a surface configured to occlude the urethral meatus, a first adhesive layer disposed on at least a first portion of the surface and configured to provide a sealing engagement between the body and the urethral meatus, and a second adhesive layer disposed over the first adhesive layer and configured to provide a sealing engagement between the body and the urethral meatus, wherein the second adhesive layer is removable from the first adhesive layer.Type: GrantFiled: March 13, 2018Date of Patent: June 27, 2023Assignee: Soft Health Technologies, LLCInventors: John Nguyen, John M. Taylor, Thomas J. Berryman