Abstract: A device and method of delivering a medical tool which may be a memory resector, cutter, probe, or the like, generally flat surface including a memory blade compacted in a small diameter state which expands in a relaxed memory state is disclosed. Said delivery may include using a hollow sheath to pre-compact or preload a memory blade into a compact position, transferring said compacted memory blade into a cannula, and deploying said memory blade from the distal end of said cannula whereby the memory blade returns to its normal expanded memory state.

Abstract: A cannulated torque-limiting device with one or more lumen therein which may mate with an additional operational tool. An A-O tip engagement for receiving and securing tips and tools for varying applications and needs is also disclosed.

Abstract: A torque-limiting device may include a shaft extending axially through upper and lower shanks and a spring to connect to a nut. The upper and lower shanks may be under a force from the spring and further configured to selectively engage within a predetermined torque limit and disengage at above the predetermined torque limit. Accordingly, the shaft may receive torque up to the predetermined limit as provided by a user operating a handle of the torque-limiting device. The torque-limiting device may be disposable, reusable, economical, and have high torque capabilities. The shaft may include a lumen extending there through, and through which a variety of devices and materials may be delivered to a workpiece.

Abstract: A torque-limiting device may include a shaft extending axially through upper and lower shanks and a spring to connect to a nut. The upper and lower shanks may be under a force from the spring and further configured to selectively engage within a predetermined torque limit and disengage at above the predetermined torque limit. Accordingly, the shaft may receive torque up to the predetermined limit as provided by a user operating a handle of the torque-limiting device. The torque-limiting device may be disposable, reusable, economical, and have high torque capabilities.

Abstract: Systems, methods, and computer program products for accessing e-learning courses from an online resource are disclosed. Graphical user interfaces (GUIs) allow students to enroll in online courses or collections of other media (e.g., video files, presentations). The courses can include in-session and self-paced courses. The courses can be delivered over a network to any number and types of student operated devices. An e-learning application running on the student-operated device provides various user interface elements that allow the student to browse, select, enroll and interact with online courses. In some implementations, the GUIs provide a display object (e.g., a virtual spiral-bound notebook) that includes tabs that can be selected by the student to navigate pages of an online course to access information, materials, posts and notes.

Abstract: This disclosure describes systems, methods, and computer program products for authoring content for e-learning courses, such as network-enabled (e.g., Web-based) education courses. Graphical user interfaces (GUIs) provide an instructor with user interface elements to manage online course content. Using the GUIs, the instructor can create in-session and self-paced courses that can be delivered over a network to any number of student operated client devices. The instructor is provided a suite of editing tools that can be used to create and edit pages of content for a course, including adding links and multimedia, information pages, posts and course materials. The GUI can include a side bar that can display descriptors that can be used by the instructor to navigate pages of the course.

Abstract: According to aspects of one or more exemplary implementations, disclosed is a flanged ribbed nut, or FRN, having a head above an extended flange formed integral to said head, and a neck integral to and extending from said flange opposite said head, and a threading guide in fluid communication with said head, flange and neck, and having at least two interfering ribs formed therein.

Abstract: A torque-limiting driver has a handle, a body, a torque-limiting assembly and a work-piece engaging tip. The torque-limiting assembly includes an upper and lower shank that have a plurality of teeth circumferentially spaced. The teeth have a vertical face, an inclined face, and a flat peak. There is a spring for applying pressure across the upper and lower shank with multiple washers interposed between the lower shaft and spring. In some instances, there is a round square drive with arched catches having preselected radii to assure operation over certain cycles at selected torque and to reduced nose cone damage and breakage at a predetermined inch pounds of torque.

Abstract: A torque-limiting driver has a handle, a body, a torque-limiting assembly and a work-piece engaging tip. The torque-limiting assembly includes an upper and lower shank that have a plurality of teeth circumferentially spaced. The teeth have a vertical face, an inclined face and a flat peak. The inclined face is defined by a radius of curvature that transitions to the flat peak. There is a spring for applying pressure across the upper and lower shank. The teeth engage for relative rotation when the handle is turned and disengage when a predetermined value of torque is exceeded.

Abstract: A torque-limiting driver has a handle, a body, a torque-limiting assembly and a work-piece engaging tip. The torque-limiting assembly includes an upper and lower shank that have a plurality of teeth circumferentially spaced. The teeth have a vertical face, an inclined face and a flat peak. The inclined face is defined by a radius of curvature that transitions to the flat peak. There is a spring for applying pressure across the upper and lower shank. The teeth engage for relative rotation when the handle is turned and disengage when a predetermined value of torque is exceeded.

Abstract: A torque-limiting driver has a handle, a body, a torque-limiting assembly and a work-piece engaging tip. The torque-limiting assembly includes an upper and lower shank that have a plurality of teeth circumferentially spaced. The teeth have a vertical face, and inclined face and a flat peak. The inclined face is defined by a radius of curvature that transitions to the flat peak. There is a spring for applying pressure across the upper and lower shank. The teeth engage for relative rotation when the handle is turned and disengage when a predetermined value of torque is exceeded.

Abstract: The instant invention teaches the inhibition of SHIP expression, or function, for the increased efficacy of autologous stem cell transplants. In another embodiment, interference with SHIP function can be used to temporarily expand and mobilize the hematopoietic stem cell compartment to assist with leukapheresis, to promote hematopoietic recovery after myeloablation treatments, to deplete target stem cell clones (such a leukemic clones and other tumor stem cell types), and to deplete, or damage, the repopulating ability of the endogenous hematopoietic stem cell pool in order to allow transplanted hematopoietic stem cells to better home and engraft and to promote in vivo expansion and mobilization of other organ-specific stem cell populations (e.g., mesenchymal, mammary).

Abstract: A torque-limiting driver has a handle, a body, a torque-limiting assembly and a work-piece engaging tip. The torque-limiting assembly includes an upper and lower shank that have a plurality of teeth circumferentially spaced. The teeth have a vertical face, and inclined face and a flat peak. The inclined face is defined by a radius of curvature that transitions to the flat peak. There is a spring for applying pressure across the upper and lower shank. The teeth engage for relative rotation when the handle is turned and disengage when a predetermined value of torque is exceeded.

Abstract: SH2 containing inositol 5?-phosphate (SHIP) modulates the activation of immune cells after recruitment to the membrane by Shc and the cytoplasmic tails of receptors. A novel SHIP isoform of approximately 104 kd expressed in primitive stem cell populations (s-SHIP) is described. It was found that s-SHIP is expressed in totipotent embryonic stem cells to the exclusion of the 145-kd SHIP isoform expressed in differentiated hematopoietic cells. s-SHIP is also expressed in primitive hematopoietic stem cells, but not in lineage-committed hematopoietic cells. In embryoic stem cells, s-SHIP partners with the adapter protein Grb2 without tyrosine phosphorylation and is present constitutively at the cell membrane. It is postulated that s-SHIP modulates the activation threshold of primitive stem cell populations.

Abstract: The instant invention teaches the inhibition of SHIP expression, or function, for the increased efficacy of autologous stem cell transplants. In another embodiment, interference with SHIP function can be used to temporarily expand and mobilize the hematopoietic stem cell compartment to assist with leukapheresis, to promote hematopoietic recovery after myeloablation treatments, to deplete target stem cell clones (such a leukemic clones and other tumor stem cell types), and to deplete, or damage, the repopulating ability of the endogenous hematopoietic stem cell pool in order to allow transplanted hematopoietic stem cells to better home and engraft and to promote in vivo expansion and mobilization of other organ-specific stem cell populations (e.g., mesenchymal, mammary).