Abstract: Methods and devices for moisturizing hyperpolarized noble gas and associated hyperpolarized noble gas products which are formulated for inhalation or ventilation delivery include adding moisture content to (dry) hyperpolarized gas.

Abstract: A circuit for determining a polarization of a gas. The circuit includes a polarimetry circuit having an NMR coil that is configured to excite a polarized gas and that is responsive to an electromagnetic signal generated by the excited, polarized gas. The polarimetry circuit has a reproducible polarization measurement variability of less than about 2% when the NMR coil is exposed to a temperature in a range of about 0° C. to about 200° C.

Abstract: A system for determining polarization of a gas comprises a container that contains the polarized gas. An oscillator circuit comprises an Nuclear Magnetic Resonance (NMR) coil that is positioned adjacent to the container. A pulse generator circuit is configured to generate an electrical pulse that may be transmitted to an optical cell through the NMR coil to excite the polarized gas responsive to a control processor. A Q-reduction circuit that is independent of the pulse generator circuit is configured to reduce oscillations in the oscillator circuit from the transmitted electrical pulse responsive to the control processor. A receive circuit is responsive to an electrical signal that is induced in the oscillator circuit due to the electromagnetic excitation of the polarized gas. The control processor is configured to determine the polarization of the gas based on the output signal of the receive circuit.

Abstract: A system for determining polarization of a gas comprises a container that contains the polarized gas. An oscillator circuit comprises an Nuclear Magnetic Resonance (NMR) coil that is positioned adjacent to the container. A pulse generator circuit is configured to generate an electrical pulse that may be transmitted to an optical cell through the NMR coil to excite the polarized gas responsive to a control processor. A Q-reduction circuit that is independent of the pulse generator circuit is configured to reduce oscillations in the oscillator circuit from the transmitted electrical pulse responsive to the control processor. A receive circuit is responsive to an electrical signal that is induced in the oscillator circuit due to the electromagnetic excitation of the polarized gas. The control processor is configured to determine the polarization of the gas based on the output signal of the receive circuit.

Abstract: Methods, systems, assemblies, computer program products and devices produce hyperpolarized gas by: (a) providing a plurality of cells (30), each having a respective quantity of target gas held therein; (b) polarizing the target gas in and/or from the cells in a desired order to provide separate batches of polarized gas; and (c) repolarizing the previously polarized target gas held in least one of the cells when the polarization level falls below a predetermined value.

Abstract: A system for determining polarization of a gas comprises a container that contains the polarized gas. An oscillator circuit comprises an NMR coil that is positioned adjacent to the container. A pulse generator circuit is configured to generate an electrical pulse that may be transmitted to the optical cell through the NMR coil to excite the polarized gas responsive to a control processor. A Q-reduction circuit that is independent of the pulse generator circuit is configured to reduce oscillations in the oscillator circuit from the transmitted electrical pulse responsive to the control processor. A receive circuit is responsive to an electrical signal that is induced in the oscillator circuit due to the electromagnetic excitation of the polarized gas. The control processor is configured to determine the polarization of the gas based on the output signal of the receive circuit.

Abstract: A system for determining polarization of a gas comprises a container that contains the polarized gas. An oscillator circuit comprises an NMR coil that is positioned adjacent to the container. A pulse generator circuit is configured to generate an electrical pulse that may be transmitted to the optical cell through the NMR coil to excite the polarized gas responsive to a control processor. A Q-reduction circuit that is independent of the pulse generator circuit is configured to reduce oscillations in the oscillator circuit from the transmitted electrical pulse responsive to the control processor. A receive circuit is responsive to an electrical signal that is induced in the oscillator circuit due to the electromagnetic excitation of the polarized gas. The control processor is configured to determine the polarization of the gas based on the output signal of the receive circuit.

Abstract: A pumping system for hyperpolarized gases employs a reversible fluid flow against a deflectable gas transport bladder. Inflation and deflation of the gas transport bladder is operably associated with valves for directing the flow of the hyperpolarized gas. A second gas transport bladder may be operably associated with additional valving so as to provide more continuous hyperpolarized gas flow. The first and second gas transport bladders may be arranged in-line with a reversible pumping mechanism.

Abstract: A system for determining polarization of a gas comprises a container that contains the polarized gas. An oscillator circuit comprises an NMR coil that is positioned adjacent to the container. A pulse generator circuit is configured to generate an electrical pulse that may be transmitted to the optical cell through the NMR coil to excite the polarized gas responsive to a control processor. A Q-reduction circuit that is independent of the pulse generator circuit is configured to reduce oscillations in the oscillator circuit from the transmitted electrical pulse responsive to the control processor. A receive circuit is responsive to an electrical signal that is induced in the oscillator circuit due to the electromagnetic excitation of the polarized gas. The control processor is configured to determine the polarization of the gas based on the output signal of the receive circuit.

Abstract: Methods of dispensing meted quantities of hyperpolarized gas to form a hyperpolarized gas mixture include pre-filling a gas syringe with a quantity of non-polarized gas, then introducing the hyperpolarized gas therein while the non-polarized gas is held therein, and expelling both the hyperpolarized gas and non-polarized gas from the syringe. Methods of inhibiting the presence of oxygen in gas flow paths and extraction systems are also described.

Abstract: Methods and devices for moisturizing hyperpolarized noble gas and associated hyperpolarized noble gas products which are formulated for inhalation or ventilation delivery include adding moisture content to (dry) hyperpolarized gas.

Abstract: Methods of dispensing meted quantities of hyperpolarized gas to form a hyperpolarized gas mixture include pre-filling a gas syringe with a quantity of non-polarized gas, then introducing the hyperpolarized gas therein while the non-polarized gas is held therein, and expelling both the hyperpolarized gas and non-polarized gas from the syringe. Methods of inhibiting the presence of oxygen in gas flow paths and extraction systems are also described.