Abstract: The invention provides a method of treating a tumor in a human patient comprising (i) identifying a patient as having a LAG-3 positive tumor and (ii) administering to the patient a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor, or an anti-CTLA4 antibody. In some embodiments, the method further comprises identifying the patient as having a LAG-3 positive PD-L1 positive tumor. In some embodiments, the LAG-3 inhibitor is an anti-LAG-3 antibody and the PD-1 pathway inhibitor is an anti-PD-1 antibody. The methods of the invention can improve response rates to treatment with a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, or a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor.

Abstract: A method of and apparatus for the rapid deployment of a fracturing water transferring system, along with the rapid picking up and storage of such system after use. In different embodiments the method in includes the use of a tensioning system to retrieve one or more segments of lay flat hose.

Abstract: A water containment apparatus includes a straight strut arrangement comprising a plurality of straight strut assemblies forming an alternating v-shape and inverted v-shape pattern; and a curved strut arrangement comprising a plurality of corner strut assemblies forming a desired curvature and connecting two straight strut arrangements to form a closed loop water containment system.

Abstract: A method of and apparatus for the rapid deployment of a fracturing water transferring system, along with the rapid picking up and storage of such system after use. In different embodiments the method in includes the use of a tensioning system to retrieve one or more segments of lay flat hose.

Abstract: A remote-controlled lifting and maneuvering device and a process of remotely controlling a trailer maneuvering device by use of a remote control is provided. The remote-controlled lifting and maneuvering device allows a single operator to both raise and lower the tongue of a trailer, and maneuver a trailer without having to apply physical force to the trailer or maneuver a towing vehicle. The lifting mechanism may be achieved using a hydraulic jack component, an electrical jack or other actuating component. The movement and maneuverability of the device may be achieved using a maneuvering system. This combination of a jack component and maneuvering system may be adapted for maneuvering a trailer into position, raising the trailer to an appropriate height, and finally lowering the trailer for affixing to a towing vehicle.

Abstract: A method of and apparatus for the rapid deployment of a fracturing water transferring system, along with the rapid picking up and storage of such system after use. In different embodiments the method in includes the use of a tensioning system to retrieve one or more segments of lay flat hose.

Abstract: A method of and apparatus for the rapid deployment of a fracturing water transferring system, along with the rapid picking up and storage of such system after use. In different embodiments the method in includes the use of a tensioning system to retrieve one or more segments of lay flat hose.

Abstract: A method of and apparatus for the rapid deployment of a fracturing water transferring system, along with the rapid picking up and storage of such system after use. In different embodiments the method in includes the use of a tensioning system to retrieve one or more segments of lay flat hose.

Abstract: A water containment apparatus includes a straight strut arrangement comprising a plurality of straight strut assemblies forming an alternating v-shape and inverted v-shape pattern; and a curved strut arrangement comprising a plurality of corner strut assemblies forming a desired curvature and connecting two straight strut arrangements to form a closed loop water containment system.

Abstract: A method of and apparatus for the rapid deployment of a fracturing water transferring system, along with the rapid picking up and storage of such system after use. In different embodiments the method in includes the use of a tensioning system to retrieve one or more segments of lay flat hose.

Abstract: Methods, systems, and computer program products are provided for rapid deployment and retrieval of a frac water transfer system.

Abstract: A method of and apparatus for the rapid deployment of a fracturing water transferring system, along with the rapid picking up and storage of such system after use. In different embodiments the method in includes the use of a tensioning system to retrieve one or more segments of lay flat hose.

Abstract: A water containment apparatus includes a straight strut arrangement comprising a plurality of straight strut assemblies forming an alternating v-shape and inverted v-shape pattern; and a curved strut arrangement comprising a plurality of corner strut assemblies forming a desired curvature and connecting two straight strut arrangements to form a closed loop water containment system.

Abstract: A method of and apparatus for the rapid deployment of a fracturing water transferring system, along with the rapid picking up and storage of such system after use. In different embodiments the method in includes the use of a tensioning system to retrieve one or more segments of lay flat hose.

Abstract: A method of and apparatus for the rapid deployment of a fracturing water transferring system, along with the rapid picking up and storage of such system after use. In different embodiments the method in includes the use of a tensioning system to retrieve one or more segments of lay flat hose.

Abstract: Methods, systems, and computer program products are provided for rapid deployment and retrieval of a frac water transfer system.

Abstract: A method of and apparatus for the rapid deployment of a fracturing water transferring system, along with the rapid picking up and storage of such system after use. In different embodiments the method in includes the use of a tensioning system to retrieve one or more segments of lay flat hose.

Abstract: Methods, systems, and computer program products are provided for rapid deployment and retrieval of a frac water transfer system.

Abstract: In an embodiment, a photovoltaic system includes multiple photovoltaic modules and a module-to-module bus. Each photovoltaic module defines a first end and a second end opposite the first end. Each photovoltaic module includes multiple photovoltaic cells and multiple converters. Energy generated by each photovoltaic cell has multiple paths through the photovoltaic cells to the second end. The converters are electrically coupled to the photovoltaic cells at the second end such that energy generated by each photovoltaic cell is receivable at any of the converters. The module-to-module bus is electrically coupled to each of the photovoltaic modules. The module-to-module bus has an output. Energy generated by each photovoltaic module is receivable at the output independent of any other of the photovoltaic modules.

Abstract: A method of and apparatus for the rapid deployment of a fracturing water transferring system, along with the rapid picking up and storage of such system after use. In different embodiments the method in includes the use of a tensioning system to retrieve one or more segments of lay flat hose.