Patents by Inventor John O'Bryan

John O'Bryan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods targeting the nucleotide free state of RAS to block oncogenic signaling and transformation
    Patent number: 12565537
    Abstract: The invention provides compositions and methods for binding Ras in a nucleotide free state (apo RAS) and inhibiting Ras signaling. In one embodiment, the invention provides monobodies that specifically bind apo RAS and methods of use. Thus, in diseases and conditions where a reduction of Ras signaling is beneficial, such inhibitory compositions act as therapeutics.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: March 3, 2026
    Assignees: MUSC Foundation for Research Development, New York University, The United States Government as Represented by the Department of Veterans Affairs
    Inventors: John O'Bryan, Shohei Koide, Akiko Koide
  • COMPOSITIONS AND METHODS TARGETING THE NUCLEOTIDE FREE STATE OF RAS TO BLOCK ONCOGENIC SIGNALING AND TRANSFORMATION
    Publication number: 20220324998
    Abstract: The invention provides compositions and methods for binding Ras in a nucleotide free state (apo RAS) and inhibiting Ras signaling. In one embodiment, the invention provides monobodies that specifically bind apo RAS and methods of use. Thus, in diseases and conditions where a reduction of Ras signaling is beneficial, such inhibitory compositions act as therapeutics.
    Type: Application
    Filed: June 18, 2020
    Publication date: October 13, 2022
    Inventors: John O'Bryan, Shohei Koide, Akiko Koide
  • Shc proteins
    Patent number: 6077686
    Abstract: A Shc protein which is characterized as follows: (a) containing a C-terminal Src homology 2 (SH2) domain, a central proline-rich region (CH1), and an N-terminal phosphotyrosine binding (PTB) domain; (b) it is predominantly expressed in the adult brain; (c) it binds through its SH2 domain to proteins containing the consensus sequence pTyr-(hydrophobic/Glu)-(hydrophobic/Met/Tyr/Ile)-(Ile/Leu/Met/Phe/Tyr); and (d) it associates through its PTB domain with proteins containing the consensus sequence Asn-Pro-X-pTyr where X is any amino acid; nucleic acids encoding the protein; and uses of the protein. The Shc proteins mediate signaling from tyrosine kinases in the nervous system.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: June 20, 2000
    Assignees: Mount Sinai Hospital Corporation, University of North Carolina at Chapel Hill
    Inventors: Channing Der, John O'Bryan, Anthony Pawson