Patents by Inventor John O. Link

John O. Link has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for the treatment of HIV
    Patent number: 10370358
    Abstract: The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: August 6, 2019
    Assignee: Gilead Sciences, Inc.
    Inventors: Steven S. Bondy, Carina E. Cannizzaro, Chien-Hung Chou, Randall L. Halcomb, Yunfeng Eric Hu, John O. Link, Qi Liu, Scott D. Schroeder, Winston C. Tse, Jennifer R. Zhang
  • Antiviral compounds
    Patent number: 10344019
    Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: July 9, 2019
    Assignee: Gilead Pharmasset LLC
    Inventors: Elizabeth M. Bacon, Jeromy J. Cottell, Ashley Anne Katana, Darryl Kato, Evan S. Krygowski, John O. Link, James G. Taylor, Chinh Tran, Teresa Alejandra Trejo Martin, Zheng-Yu Yang, Sheila M. Zipfel
  • Pyrrolo[1,2-b]pyridazine derivatives
    Patent number: 10336762
    Abstract: Provided is a compound of Formula (I) wherein the variable groups are defined herein.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: July 2, 2019
    Assignee: Gilead Sciences, Inc.
    Inventors: Elizabeth M. Bacon, Gediminas Brizgys, Elbert Chin, Chienhung Chou, Jeromy J. Cottell, John O. Link, James G. Taylor, Winston C. Tse, Nathan E. Wright, Zheng-Yu Yang, Jennifer R. Zhang, Sheila M. Zipfel
  • Inhibitors of hepatitis C virus
    Patent number: 10335409
    Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: July 2, 2019
    Assignee: Gilead Pharmasset LLC
    Inventors: Kyla Bjornson, Eda Canales, Jeromy J. Cottell, Kapil K. Karki, Ashley A. Katana, Darryl Kato, Tetsuya Kobayashi, John O. Link, Ruben Martinez, Barton W. Phillips, Hyung-jung Pyun, Michael Sangi, Adam J. Schrier, Dustin Siegel, James G. Taylor, Chinh V. Tran, Teresa A. Trejo Martin, Randall W. Vivian, Zheng-Yu Yang, Jeff Zablocki, Sheila Zipfel
  • COT modulators and methods of use thereof
    Patent number: 10316017
    Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: June 11, 2019
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Elizabeth M. Bacon, Gayatri Balan, Chien-Hung Chou, Christopher T. Clark, Jeromy J. Cottell, Musong Kim, Thorsten A. Kirschberg, John O. Link, Gary Phillips, Scott D. Schroeder, Neil H. Squires, Kirk L. Stevens, James G. Taylor, William J. Watkins, Nathan E. Wright, Sheila M. Zipfel
  • HIV inhibitor compounds
    Patent number: 10294234
    Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: May 21, 2019
    Assignee: Gilead Sciences, Inc.
    Inventors: Elizabeth M. Bacon, Elbert Chin, Jeromy J. Cottell, Ashley Anne Katana, Darryl Kato, John O. Link, Nathan Shapiro, Teresa Alejandra Trejo Martin, Zheng-Yu Yang
  • Therapeutic compounds
    Patent number: 10202353
    Abstract: Compounds of Formula I, or salts thereof, are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, intermediates useful for preparing compounds of Formula I and therapeutic, methods for treating a Retroviridae viral infection, in particular infection caused by the HIV virus.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: February 12, 2019
    Assignee: Gilead Sciences, Inc.
    Inventors: Steven S. Bondy, Chien-Hung Chou, John O. Link, Winston C. Tse
  • COT MODULATORS AND METHODS OF USE THEREOF
    Publication number: 20190016705
    Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
    Type: Application
    Filed: July 25, 2018
    Publication date: January 17, 2019
    Inventors: Gayatri Balan, Chienhung Chou, Musong Kim, Thorsten A. Kirschberg, John O. Link, Gary Phillips, Roland D. Saito, Neil H. Squires, James G. Taylor, William J. Watkins, Nathan E. Wright
  • INHIBITORS OF HEPATITIS C VIRUS
    Publication number: 20190008858
    Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
    Type: Application
    Filed: June 11, 2018
    Publication date: January 10, 2019
    Inventors: Kyla Bjornson, Eda Canales, Jeromy J. Cottell, Kapil K. Karki, Ashley A. Katana, Darryl Kato, Tetsuya Kobayashi, John O. Link, Ruben Martinez, Barton W. Phillips, Hyung-jung Pyun, Michael Sangi, Adam J. Schrier, Dustin Siegel, James G. Taylor, Chinh V. Tran, Teresa A. Trejo Martin, Randall W. Vivian, Zheng-Yu Yang, Jeff Zablocki, Sheila Zipfel
  • THERAPEUTIC COMPOUNDS
    Publication number: 20180370950
    Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.
    Type: Application
    Filed: June 25, 2018
    Publication date: December 27, 2018
    Inventors: Michael Graupe, Steven J. Henry, John O. Link, Charles William Rowe, Roland D. Saito, Scott D. Schroeder, Dimitrios Stefanidis, Winston C. Tse, Jennifer R. Zhang
  • Compounds for the treatment of hepatitis B virus infection
    Patent number: 10100052
    Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: October 16, 2018
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Evangelos Aktoudianakis, Eda Canales, Elbert Chin, Kevin S. Currie, Ashley Anne Katana, Darryl Kato, John O. Link, Samuel E. Metobo, Roland D. Saito, Zheng-Yu Yang
  • THERAPEUTIC COMPOUNDS
    Publication number: 20180273508
    Abstract: Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
    Type: Application
    Filed: March 2, 2018
    Publication date: September 27, 2018
    Inventors: Gediminas Brizgys, Eda Canales, Chien-Hung Chou, Michael Graupe, Randall L. Halcomb, Yunfeng Eric Hu, Scott E. Lazerwith, John O. Link, Qi Liu, Yafan Lu, Roland D. Saito, Scott D. Schroeder, John R. Somoza, Winston C. Tse, Jennifer R. Zhang
  • HIV INHIBITOR COMPOUNDS
    Publication number: 20180258097
    Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
    Type: Application
    Filed: February 5, 2018
    Publication date: September 13, 2018
    Inventors: Elizabeth M. Bacon, Elbert Chin, Jeromy J. Cottell, Ashley Anne Katana, Darryl Kato, John O. Link, Nathan Shapiro, Teresa Alejandra Trejo Martin, Zheng-Yu Yang
  • Therapeutic compounds
    Patent number: 10071985
    Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: September 11, 2018
    Assignee: Gilead Sciences, Inc.
    Inventors: Michael Graupe, Steven J. Henry, John O. Link, Charles William Rowe, Roland D. Saito, Scott D. Schroeder, Dimitrios Stefanidis, Winston C. Tse, Jennifer R. Zhang
  • COMPOUNDS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION
    Publication number: 20180251460
    Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.
    Type: Application
    Filed: January 31, 2018
    Publication date: September 6, 2018
    Inventors: Evangelos Aktoudianakis, Eda Canales, Kevin S. Currie, Darryl Kato, Jiayao Li, John O. Link, Samuel E. Metobo, Roland D. Saito, Scott D. Schroeder, Nathan Shapiro, Winston C. Tse, Qiaoyin Wu
  • ANTIVIRAL COMPOUNDS
    Publication number: 20180244684
    Abstract: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: January 22, 2018
    Publication date: August 30, 2018
    Inventors: JOHN O. LINK, Jeromy J. Cottell, Teresa Alejandra Trejo Martin, Elizabeth M. Bacon
  • ANTIVIRAL COMPOUNDS
    Publication number: 20180244683
    Abstract: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: October 4, 2017
    Publication date: August 30, 2018
    Inventors: Elizabeth M. Bacon, Jeromy J. Cottell, Ashley Anne Katana, Darryl Kato, Evan S. Krygowski, John O. Link, James G. Taylor, Chinh Viet Tran, Teresa Alejandra Trejo Martin, Zheng-Yu Yang, Sheila M. Zipfel
  • Cot modulators and methods of use thereof
    Patent number: 10059695
    Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: August 28, 2018
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Gayatri Balan, Chien-Hung Chou, Musong Kim, Thorsten A. Kirschberg, John O. Link, Gary Phillips, Roland D. Saito, Neil H. Squires, James G. Taylor, William J. Watkins, Nathan E. Wright
  • COT MODULATORS AND METHODS OF USE THEREOF
    Publication number: 20180237455
    Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
    Type: Application
    Filed: February 7, 2018
    Publication date: August 23, 2018
    Inventors: Elizabeth M. Bacon, Gayatri Balan, Chien-Hung Chou, Christopher T. Clark, Jeromy J. Cottell, Musong Kim, Thorsten A. Kirschberg, John O. Link, Gary Phillips, Scott D. Schroeder, Neil H. Squires, Kirk L. Stevens, James G. Taylor, William J. Watkins, Nathan E. Wright, Sheila M. Zipfel
  • PYRROLO[1,2-b]PYRIDAZINE DERIVATIVES
    Publication number: 20180230157
    Abstract: Provided is a compound of Formula (I) wherein the variable groups are defined herein.
    Type: Application
    Filed: February 15, 2018
    Publication date: August 16, 2018
    Inventors: Elizabeth M. Bacon, Gediminas Brizgys, Elbert Chin, Cheinhung Chou, Jeromy J. Cottell, John O. Link, James G. Taylor, winston C. Tse, Nathan E. Wright, Zheng-Yu Yang, Jennifer R. Zhang, Sheila M. Zipfel