Patents by Inventor John O. Trent

John O. Trent has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PFKB3 inhibitor for the treatment of a proliferative cancer
    Patent number: 8088385
    Abstract: A methods and compounds for inhibiting 6-phosphofructo-2-kinase /fructose-2,6-bisphosphatase 3 (PFKFB3) are described. Also described are methods of inhibiting cell proliferation, treating cancer, and screening compounds to determine their ability to inhibit PFKFB3.
    Type: Grant
    Filed: June 18, 2008
    Date of Patent: January 3, 2012
    Assignee: University of Louisville Research Foundation Inc.
    Inventors: Jason Chesney, John O. Trent, Sucheta Telang, Brian Clem, Jason Meier
  • Small-Molecule Choline Kinase Inhibitors as Anti-Cancer Therapeutics
    Publication number: 20110257211
    Abstract: Small molecule choline kinase inhibitors having the following formula: are provided herein. Also provided herein are pharmaceutical compositions containing Formula I compounds, together with methods of treating cancer, methods of inhibiting choline kinase enzymatic activity, and methods of treating tumors by administering an effective amount of a Formula I compound.
    Type: Application
    Filed: December 22, 2010
    Publication date: October 20, 2011
    Applicants: ADVANCED CANCER THERAPEUTICS, LLC, UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Pooran Chand, Jason A. Chesney, Brian F. Clem, Gilles H. Tapolsky, Sucheta Telang, John O. Trent
  • Method for the diagnosis and prognosis of malignant diseases
    Patent number: 8029784
    Abstract: Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin.
    Type: Grant
    Filed: March 4, 2008
    Date of Patent: October 4, 2011
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Paula J. Bates, Donald M. Miller, John O. Trent, Xiaohua Xu
  • Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
    Publication number: 20110178161
    Abstract: Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic; hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 21, 2011
    Applicant: Antisoma Research Limited
    Inventors: John O. Trent, Paula J. Bates, Donald M. Miller
  • Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
    Patent number: 7960540
    Abstract: Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: June 14, 2011
    Assignee: Advanced Cancer Therapeutics, LLC
    Inventors: John O. Trent, Paula J. Bates, Donald M. Miller
  • MACROPHAGE MIGRATION INHIBITORY FACTOR ANTAGONISTS AND METHODS OF USING SAME
    Publication number: 20110009412
    Abstract: Methods of inhibiting one or more biological activities of Macrophage migration inhibitory factor (MIF) polypeptides are provided using an MIF inhibitory compound. The methods include therapeutic methods for treating cancers and inflammatory diseases.
    Type: Application
    Filed: May 24, 2007
    Publication date: January 13, 2011
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Robert A. Mitchell, John O. Trent, Jason B. Meier
  • Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
    Publication number: 20090326047
    Abstract: The present invention provides a method for inhibiting the proliferation of malignant and/or hyperplastic cells in a subject by administering to the subject a therapeutically effective amount of a guanosine rich oligonucleotide. The present invention also provides oligonucleotides which are capable of being specifically bound to a specific cellular protein which is nucleolin and/or nucleolin in nature, which is implicated in the proliferation of cells, specifically malignant and/or hyperplastic cells, and a method for their selection.
    Type: Application
    Filed: October 29, 2004
    Publication date: December 31, 2009
    Inventors: Donald M. Miller, Paula J. Bates, John O. Trent
  • Method for the diagnosis and prognosis of malignant diseases
    Patent number: 7541150
    Abstract: Methods for the diagnosis of cancer by determining the neoplastic status of a cell by probing the cell plasma membrane for the presence of nucleolin are provided, as are kits to carry out such tests.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: June 2, 2009
    Assignee: University of Louisville Research Foundation, Inc
    Inventors: Donald M. Miller, Paula J. Bates, John O. Trent, Xiaohua Xu
  • FAMILY OF PFKFB3 INHIBITORS WITH ANTI-NEOPLASTIC ACTIVITIES
    Publication number: 20090074884
    Abstract: A methods and compounds for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) are described. Also described are methods of inhibiting cell proliferation, treating cancer, and screening compounds to determine their ability to inhibit PFKFB3.
    Type: Application
    Filed: June 18, 2008
    Publication date: March 19, 2009
    Inventors: Jason Chesney, John O. Trent, Sucheta Telang, Brian Clem, Jason Meier
  • METHOD FOR THE DIAGNOSIS AND PROGNOSIS OF MALIGNANT DISEASES
    Publication number: 20090017009
    Abstract: Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin.
    Type: Application
    Filed: March 4, 2008
    Publication date: January 15, 2009
    Inventors: Paula J. Bates, Donald M. Miller, John O. Trent, Xiaohua Xu
  • Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
    Publication number: 20080318889
    Abstract: Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.
    Type: Application
    Filed: October 31, 2007
    Publication date: December 25, 2008
    Applicant: Antisoma Research Limited
    Inventors: John O. Trent, Paula J. Bates, Donald M. Miller
  • Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
    Publication number: 20080318890
    Abstract: Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.
    Type: Application
    Filed: October 31, 2007
    Publication date: December 25, 2008
    Applicant: Antisoma Research Limited
    Inventors: John O. Trent, Paula J. Bates, Donald M. Miller
  • Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
    Publication number: 20080318887
    Abstract: Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.
    Type: Application
    Filed: October 31, 2007
    Publication date: December 25, 2008
    Applicant: Antisoma Research Limited
    Inventors: John O. Trent, Paula J. Bates, Donald M. Miller
  • Antiproliferative activity of g-rich oligonucleotides and method of using same to bind to nucleolin
    Publication number: 20080318888
    Abstract: Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.
    Type: Application
    Filed: October 31, 2007
    Publication date: December 25, 2008
    Applicant: Antisoma Research Limited
    Inventors: John O. Trent, Paula J. Bates, Donald M. Miller
  • Method for the diagnosis and prognosis of malignant diseases
    Patent number: 7357928
    Abstract: Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: April 15, 2008
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Paula J. Bates, Donald M. Miller, John O. Trent, Xiaohua Xu
  • Antiproliferative activity of g-rich oligonucleotides and method of using same to bind to nucleolin
    Patent number: 7314926
    Abstract: The present invention provides a method for inhibiting the proliferation of malignant and/or hyperplastic cells in a subject by administering to the subject a therapeutically effective amount of a guanosine rich oligonucleotide. The present invention also provides oligonucleotides which are capable of being specifically bound to a specific cellular protein which is nucleolin and/or nucleolin-like in nature, which is implicated in the proliferation of cells, specifically malignant and/or hyperplastic cells, and a method for their selection.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: January 1, 2008
    Assignee: Antisoma Research Limited
    Inventors: Donald M. Miller, Paula J. Bates, John O. Trent
  • Method for the diagnosis and prognosis of malignant diseases
    Publication number: 20030194754
    Abstract: Methods for the diagnosis of cancer by determining the neoplastic status of a cell by probing the cell plasma membrane for the presence of nucleolin are provided, as are kits to carry out such tests.
    Type: Application
    Filed: April 8, 2002
    Publication date: October 16, 2003
    Inventors: Donald M. Miller, Paula J. Bates, John O. Trent, Xiaohua Xu