Patents by Inventor John Ortaldo

John Ortaldo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel form of interleukin-15, Fc-IL-15, and methods of use
    Publication number: 20060257361
    Abstract: The present invention relates to Fc-IL-15 hybrids, which may or may not include peptide linkers between the IL-15 and the Fc portion, for methods of treatment of tumors and viral infections. The IL-15 hybrids can be Fc-IL-15 or IL-15-Fc hybrids. The Fc-IL-15 hybrids include variants, including the IL-15 and Fc variants. The hybrids preferably (but not necessarily) include peptide linkers between the IL-15 and the Fc portion. These linkers are preferably composed of a T cell inert sequence, or any non-immunogenic sequence.
    Type: Application
    Filed: April 12, 2006
    Publication date: November 16, 2006
    Applicant: Government of the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: Morihiro Watanabe, Hiroshi Yazawa, John Ortaldo, Robert Wiltrout
  • Enhanced intercellular interaction by associational antibody molecules
    Patent number: 5693322
    Abstract: A method to enhance intercellular association between two or more cells through the linking of attachment molecules on the cellular surfaces of the cells is described. Appropriate attachment molecules include antibodies having an IgG.sub.3 isotype that can cross-associate with antibodies on other cells to bring the cells into proximity with one another. An enhanced method to kill tumor cells with effector cells is also provided.
    Type: Grant
    Filed: March 11, 1993
    Date of Patent: December 2, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Stephen P. Creekmore, Toby T. Hecht, John Ortaldo