Abstract: A method of equalising an audio signal derived from a microphone, the method comprising: receiving the audio signal; applying an order-statistic filter to the audio signal in the frequency domain to generate a statistically filtered audio signal; equalising the received audio signal based on the statistically filtered audio signal to generate an equalised audio signal.

Abstract: One exemplary embodiment is directed to a system comprising a switch used in a network and a central function configured to receive physical layer information related to the network. The physical layer information includes information associating media access control (MAC) addresses of devices on the network with ports of the switch. The switch is configured to use information about a spanning tree determined by the central function to configure the switch to carry out a switching function performed by the switch. The central function is configured to use at least some physical layer information about patching equipment in the network and end devices in the network in associating MAC addresses of devices on the network with the ports of the switch. Other embodiments are disclosed.

Abstract: One exemplary embodiment is directed to an end node comprising a programmable processor configured to execute software and an ETHERNET network interface communicatively coupled to the programmable processor. The network interface is configured to couple the end node to a network. The ETHERNET network interface comprises a media access control device, an ETHERNET physical layer device, and a port to connect a cable to the network interface. The physical layer device comprises an integrated storage-device interface to communicate with a storage device associated with a connector attached to an end of the cable when connected to the network interface via the port. The software is configured to use the integrated storage-device interface to read information stored in the storage device and to communicate the read information over the network.

Abstract: The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.

Abstract: One exemplary embodiment is directed to an end node that includes functionality to read information stored on or in a segment of physical communication media that is attached to the end node and to communicate the read information over a network (for example, to an aggregation point). Another exemplary embodiment is directed a wall outlet that includes functionality to read information stored on or in a segment of physical communication media connected to it and communicate at least a portion of the information read from the segment of physical communication media to an aggregation point. Another exemplary embodiment is directed a wall outlet that includes a switch and functionality to read information stored on or in a segment of physical communication media connected to it and to communicate at least a portion of the information read from the segment of physical communication media to an aggregation point.

Abstract: A universal cable bracket that enables one or more cables to be secured to a telecommunications chassis accommodates cables of various sizes and styles. The cable bracket is configured to be mounted in one of multiple orientations relative to the chassis. One or more fasteners can be inserted through apertures in the bracket and a chassis mounting surface to secure the bracket into the desired orientation. Cables or fanout arrangements can be secured to a platform of the bracket via cable ties or other windings.

Abstract: The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.

Abstract: One exemplary embodiment is directed to a system comprising a switch used in a network and a central function configured to receive physical layer information related to the network. The physical layer information includes information associating media access control (MAC) addresses of devices on the network with ports of the switch. The switch is configured to use information about a spanning tree determined by the central function to configure the switch to carry out a switching function performed by the switch. The central function is configured to use at least some physical layer information about patching equipment in the network and end devices in the network in associating MAC addresses of devices on the network with the ports of the switch. Other embodiments are disclosed.

Abstract: One exemplary embodiment is directed to a network management system that uses physical layer information in performing a network management function. Another exemplary embodiment is directed to a method of tracking channel compliance using physical layer information.

Abstract: The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.

Abstract: An exemplary system includes a plurality of connector assemblies. Each of the connector assemblies includes a plurality of ports. Each of the connector assemblies is configured to read information stored on or in physical communication media that is connected to the ports of the respective connector assembly. An aggregation point is communicatively coupled to the plurality of connector assemblies. The aggregation point is configured to automatically discover the connector assemblies and cause each of the connector assemblies to send to the aggregation point at least some of the information read from the physical communication media that is connected to its ports. The aggregation point is configured to store at least some of the information sent by the connector assemblies to the aggregation point. The aggregation point can also be configured to provide at least some of the information it stores to at least one other device via the network.

Abstract: One exemplary embodiment is directed to an inter-networking device that performs at least one inter-networking function using physical layer information about the network of which the device is a part. Another exemplary embodiment is directed to capturing physical layer information about physical communication media that is attached to an inter-networking device. Another exemplary embodiment is directed to a technique for generating a spanning tree and/or forwarding database information for a plurality of switches in a network at a central location. The spanning tree and/or forwarding database information is generated at the central location using information including physical layer information about devices and physical communication media in the network. Another exemplary embodiment is directed to an ETHERNET physical layer device having integrated support for capturing physical layer information about the physical communication media connected to the ETHERNET physical layer device.

Abstract: A universal cable bracket that enables one or more cables to be secured to a telecommunications chassis accommodates cables of various sizes and styles. The cable bracket is configured to be mounted in one of multiple orientations relative to the chassis. One or more fasteners can be inserted through apertures in the bracket and a chassis mounting surface to secure the bracket into the desired orientation. Cables or fanout arrangements can be secured to a platform of the bracket via cable ties or other windings.

Abstract: An exemplary optical distribution frame includes a frame structure defining multiple positions into which multiple chassis can be inserted and a frame controller unit attached to the frame structure. The frame structure includes a frame controller and a switch communicatively coupled to the frame controller, wherein the switch includes a multiple ports. The frame structure including multiple cables, each cable being attached to a respective one of the ports of the switch and routed and attached to the optical distribution frame so that each cable can be attached to a chassis inserted into a predetermined one of the positions in the optical distribution frame, wherein the frame controller is configured to communicate port mapping information to a management entity that is communicatively coupled to the frame controller for use by the management entity in associating location information with a chassis inserted into the optical distribution frame.

Abstract: One exemplary embodiment is directed to a network management system that uses physical layer information in performing a network management function. Another exemplary embodiment is directed to a method of tracking channel compliance using physical layer information.

Abstract: One exemplary embodiment is directed to a network management system that uses physical layer information in performing a network management function. Another exemplary embodiment is directed to a method of tracking channel compliance using physical layer information.

Abstract: One exemplary embodiment is directed to an inter-networking device that performs at least one inter-networking function using physical layer information about the network of which the device is a part. Another exemplary embodiment is directed to capturing physical layer information about physical communication media that is attached to an inter-networking device. Another exemplary embodiment is directed to a technique for generating a spanning tree and/or forwarding database information for a plurality of switches in a network at a central location. The spanning tree and/or forwarding database information is generated at the central location using information including physical layer information about devices and physical communication media in the network. Another exemplary embodiment is directed to an ETHERNET physical layer device having integrated support for capturing physical layer information about the physical communication media connected to the ETHERNET physical layer device.

Abstract: The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, X, R1, R2, R3, R4, R5 and R6, are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

Abstract: One exemplary embodiment is directed to an inter-networking device that performs at least one inter-networking function using physical layer information about the network of which the device is a part. Another exemplary embodiment is directed to capturing physical layer information about physical communication media that is attached to an inter-networking device. Another exemplary embodiment is directed to a technique for generating a spanning tree and/or forwarding database information for a plurality of switches in a network at a central location. The spanning tree and/or forwarding database information is generated at the central location using information including physical layer information about devices and physical communication media in the network. Another exemplary embodiment is directed to an ETHERNET physical layer device having integrated support for capturing physical layer information about the physical communication media connected to the ETHERNET physical layer device.

Abstract: An exemplary optical distribution frame includes a frame structure defining multiple positions into which multiple chassis can be inserted and a frame controller unit attached to the frame structure. The frame structure includes a frame controller and a switch communicatively coupled to the frame controller, wherein the switch includes a multiple ports. The frame structure including multiple cables, each cable being attached to a respective one of the ports of the switch and routed and attached to the optical distribution frame so that each cable can be attached to a chassis inserted into a predetermined one of the positions in the optical distribution frame, wherein the frame controller is configured to communicate port mapping information to a management entity that is communicatively coupled to the frame controller for use by the management entity in associating location information with a chassis inserted into the optical distribution frame.