Abstract: The invention encompasses an antibody that binds to and substantially inhibits the activity of at least one poxvirus complement inhibitor. Additionally, the application encompasses methods of detecting a poxvirus complement inhibitor and methods of decreasing the activity of a poxvirus complement inhibitor.

Abstract: Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which affect the complement inhibitory activities of these proteins, substituting, rearranging or adding SCRs (short consensus repeats) or SCR regions to the proteins, deleting amino acid sequences, and combinations thereof.

Abstract: Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which affect the complement inhibitory activities of these proteins, substituting, rearranging or adding SCRs (short consensus repeats) or SCR regions to the proteins, deleting amino acid sequences, and combinations thereof.

Abstract: Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which effect the binding of these proteins, identified as amino acids 35, 64-65, 92-94 (C4b) and the sequence S-T-K-P-(P-I-C)-Q (C3b) in the CR1 protein can be transferred to corresponding regions of CR1 or of additional members of the RCA family. Analogs can also be designed by substituting amino acids which affect the binding of these proteins into homologous regions of noncorresponding SCRs of CR1 or other family members.

Abstract: Human membrane cofactor protein, a protein involved in regulation of complement activity, has been purified to homogeneity. The gene encoding this protein has been retrieved and permits deduction of the entire amino acid sequence and the recombinant production of this material. Pharmaceutical compositions in which MCP is the active ingredient for use in treating antoimmune diseases are also disclosed.

Abstract: Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which effect the binding of these proteins, identified as amino acids 35, 64-65, 92-94 (C4b) and the sequence S-T-K-P-(P-I-C)-Q (amino acids at positions 54-61 of SEQ ID NO. 13) (C3b) in the CR1 protein can be transferred to corresponding regions of CR1 or of additional members of the RCA family. Analogs can also be designed by substituting amino acids which affect the binding of these proteins into homologous regions of noncorresponding SCRs of CR1 or other family members.

Abstract: Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which effect the binding of these proteins, identified as amino acids 35, 64-65, 92-94 (C4b) and the sequence S-T-K-P-(P-I-C)-Q (C3b) in the CR1 protein can be transferred to corresponding regions of CR1 or of additional members of the RCA family. Analogs can also be designed by substituting amino acids which affect the binding of these proteins into homologous regions of noncorresponding SCRs of CR1 or other family members.

Abstract: Human membrane cofactor protein, a protein involved in regulation of complement activity, has been purified to homogeneity. The gene encoding this protein has been retrieved and permits deduction of the entire amino acid sequence and the recombinant production of this material. Pharmaceutical compositions in which MCP is the active ingredient for use in treating antoimmune diseases are also disclosed.

Abstract: Human membrane cofactor protein (MCP), a protein involved in regulation of complement activity, has been purified to homogeneity. The cDNAs encoding six isoforms of this protein have been retrieved and permit deduction of the complete amino acid sequences and the recombinant production of proteins with this activity. Pharmaceutical compositions in which MCP is the active ingredient for use in treating autoimmune diseases, antibody preparations for diagnosis, and DNA probes are also disclosed.

Abstract: Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which effect the binding of these proteins, identified as amino acids 35, 64-65, 92-94 (C4b) and the sequence S-T-K-P-(P-I-C)-Q (SEQ ID NO:1) (C3b) in the CR1 protein can be transferred to corresponding regions of CR1 or of additional members of the RCA family. Analogs can also be designed by substituting amino acids which affect the binding of these proteins into homologous regions of noncorresponding SCRs of CR1 or other family members.

Abstract: Human membrane cofactor protein, a protein involved in regulation of complement activity, has been purified to homogeneity. The gene encoding this protein has been retrieved and permits deduction of the entire amino acid sequence and the recombinant production of this material. Pharmaceutical compositions in which MCP is the active ingredient for use in treating autoimmune diseases are also disclosed.