Patents by Inventor John P. Bannantine

John P. Bannantine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11981750
    Abstract: The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map) S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.
    Type: Grant
    Filed: October 7, 2022
    Date of Patent: May 14, 2024
    Assignees: INSTITUT PASTEUR, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE L'ALIMENTATION ET L'ENVIRONNEMENT, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
    Inventors: John P. Bannantine, Gilles Etienne, Sylvie Bay, Franck Biet
  • Publication number: 20230320354
    Abstract: The invention relates to new tunicamycin structures comprising N-acyl groups metabolically integrated into the terminus of the TUN via the Streptomyces branched chain fatty acid pathways and variants thereof, and methods of preparing such new tunicamycin structures. The invention further relates to antibacterial compositions comprising such new tunicamycin structures, and methods for using such antibacterial compositions for killing Gram-positive bacteria.
    Type: Application
    Filed: April 12, 2022
    Publication date: October 12, 2023
    Inventors: Neil P. Price, Michael A. Jackson, Trina M. Hartman, John P. Bannantine
  • Publication number: 20230046953
    Abstract: The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map)S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.
    Type: Application
    Filed: October 7, 2022
    Publication date: February 16, 2023
    Inventors: John P. BANNANTINE, Gilles ETIENNE, Sylvie BAY, Franck BIET
  • Patent number: 11498942
    Abstract: The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map) S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: November 15, 2022
    Assignees: INSTITUT PASTEUR, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
    Inventors: John P. Bannantine, Gilles Etienne, Sylvie Bay, Franck Biet
  • Publication number: 20200348300
    Abstract: The present invention provides novel Mycobacterium avium subspecies paratuberculsis (MAP) derived antigens which may be used to diagnose and thereafter effectively treat animals that have been infected with MAP, Further provided are methods of determining whether an animal is infected with MAP, and methods of diagnosing and treating Johne's disease. The invention also relates to a kit for the implementation of the methods.
    Type: Application
    Filed: January 18, 2019
    Publication date: November 5, 2020
    Inventors: Vivek Kapur, Lingling Li, Joseph J. Campo, Yrjo T. Grohn, Bettina Wagner, John P. Bannantine, Judith R. Stabel
  • Publication number: 20200024307
    Abstract: The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map) S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.
    Type: Application
    Filed: December 20, 2017
    Publication date: January 23, 2020
    Inventors: John P. BANNANTINE, Gilles ETIENNE, Sylvie BAY, Franck BIET
  • Patent number: 9175049
    Abstract: Compositions of immunogenic proteins of Mycobacterium avium subspecies paratuberculosis (MAP) are effective for stimulating a protective immune response in animals against MAP. Combinations of MAP1087 with two or more of MAP1204, MAP1272c and MAP2077c are effective for stimulating a protective immune response in animals against MAP and can be administered as vaccines against paratuberculosis (Johne's disease). Induction of the immune response significantly reduces or eliminates colonization of the animal by MAP, and consequently reduces or eliminates the symptoms of clinical disease in animals infected with MAP and reduces or eliminates fecal shedding of MAP. Vaccination with the compositions provides protection against clinical disease and reduces transmission of MAP infection within a herd.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: November 3, 2015
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Judith R. Stabel, John P. Bannantine
  • Patent number: 9145456
    Abstract: Hybridoma cell lines which produce and secrete monoclonal antibodies which selectively bind to Mycobacterium avium subspecies paratuberculosis have been produced. Cells of M. avium subspecies paratuberculosis in biological samples may be detected and quantified by contacting the sample with the antibodies to form a M. avium subspecies paratuberculosis/antibody immunocomplex when M. avium subspecies paratuberculosis is present, which immunocomplex may then be detected. The monoclonal antibodies also may be incorporated into kits for the detection and quantification of M. avium subspecies paratuberculosis.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: September 29, 2015
    Assignee: The United States of America, as represented by The Secretary of Agriculture
    Inventor: John P. Bannantine
  • Publication number: 20140112949
    Abstract: Compositions of immunogenic proteins of Mycobacterium avium subspecies paratuberculosis (MAP) are effective for stimulating a protective immune response in animals against MAP. Combinations of MAP1087 with two or more of MAP1204, MAP1272c and MAP2077c are effective for stimulating a protective immune response in animals against MAP and can be administered as vaccines against paratuberculosis (Johne's disease). Induction of the immune response significantly reduces or eliminates colonization of the animal by MAP, and consequently reduces or eliminates the symptoms of clinical disease in animals infected with MAP and reduces or eliminates fecal shedding of MAP. Vaccination with the compositions provides protection against clinical disease and reduces transmission of MAP infection within a herd.
    Type: Application
    Filed: September 26, 2013
    Publication date: April 24, 2014
    Inventors: Judith R. Stabel, John P. Bannantine
  • Patent number: 8658386
    Abstract: Hybridoma cell lines which produce and secrete monoclonal antibodies which selectively bind to Mycobacterium avium subspecies paratuberculosis have been produced. Cells of M. avium subspecies paratuberculosis in biological samples may be detected and quantified by contacting the sample with the antibodies to form a M. avium subspecies paratuberculosis/antibody immunocomplex when M. avium subspecies paratuberculosis is present, which immunocomplex may then be detected. The monoclonal antibodies also may be incorporated into kits for the detection and quantification of M. avium subspecies paratuberculosis.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: February 25, 2014
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventor: John P. Bannantine
  • Patent number: 7867704
    Abstract: The present invention provides nucleic acid molecules unique to M. paratuberculosis. The invention also provides the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules of the invention, and antibodies having specific binding affinity for the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules. The invention further provides for methods of detecting M. paratuberculosis in a sample using nucleic acid molecules, polypeptides, and antibodies of the invention. The invention additionally provides methods of preventing a M. paratuberculosis infection in an animal.
    Type: Grant
    Filed: September 3, 2004
    Date of Patent: January 11, 2011
    Assignees: Regents of the University of Minnesota, The United States of America as represented by the Secretary of Agriculture
    Inventors: Vivek Kapur, John P. Bannantine, Ling-Ling Li, Qing Zhang, Alongkorn Amonsin
  • Patent number: 7851170
    Abstract: Hybridoma cell lines which produce and secrete monoclonal antibodies which selectively bind to Mycobacterium avium subspecies paratuberculosis have been produced. Cells of M. avium subspecies paratuberculosis in biological samples may be detected and quantified by contacting the sample with the antibodies to form a M. avium subspecies paratuberculosis/antibody immunocomplex when M. avium subspecies paratuberculosis is present, which immunocomplex may then be detected. The monoclonal antibodies also may be incorporated into kits for the detection and quantification of M. avium subspecies paratuberculosis.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: December 14, 2010
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventor: John P. Bannantine
  • Patent number: 7604953
    Abstract: A process of detection of the causative agent of Johne's disease (Mycobacterium avium subsp. paratuberculosis) (MAP) by detecting shedding of surface protein of MAP. A preferred way is use of surface enhanced Raman Spectroscopy. The system of detecting MAP shedding of protein provides early detection and diagnosis, and therefore allows early treatment for Johne's disease in ruminant animals.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: October 20, 2009
    Assignees: Iowa State University Research Foundation, Inc., The United States of America as represented by the Department of Agriculture/Cooperative State Research Education and Extension Service (USDA/CSREES)
    Inventors: Marc D. Porter, Betsy Jean Yakes, Robert J. Lipert, John P. Bannantine
  • Publication number: 20090017480
    Abstract: A process of detection of the causative agent of Johne's disease (Mycobacterium avium subsp. paratuberculosis) (MAP) by detecting shedding of surface protein of MAP. A preferred way is use of surface enhanced Raman Spectroscopy. The system of detecting MAP shedding of protein provides early detection and diagnosis, and therefore allows early treatment for Johne's disease in ruminant animals.
    Type: Application
    Filed: May 30, 2008
    Publication date: January 15, 2009
    Inventors: MARC D. PORTER, BETSY JEAN YAKES, ROBERT J. LIPERT, JOHN P. BANNANTINE
  • Patent number: 7074559
    Abstract: The present invention provides nucleic acid molecules unique to M. paratuberculosis. The invention also provides the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules of the invention, and antibodies having specific binding affinity for the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules. The invention further provides for methods of detecting M. paratuberculosis in a sample using nucleic acid molecules, polypeptides, and antibodies of the invention. The invention additionally provides methods of preventing a M. paratuberculosis infection in an animal.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: July 11, 2006
    Assignees: Refents of the University of Minnesota, The Unites States of America as represented by the Secretary of Agriculture
    Inventors: Vivek Kapur, John P. Bannantine, Ling-Ling Li, Qing Zhang, Alongkorn Amonsin
  • Patent number: 6746676
    Abstract: Certain Chlamydia proteins have been found to be infection-specific and to be associated primarily with the vegetative Reticulate Body form of Chlamydia rather than with the refractile Elementary Body form of Chlamydia. The invention includes a vaccine directed against the Reticulate Body form of Chlamydia comprising one or more infection-specific proteins, or fraction thereof; a method of using such a vaccine; a method of production of such a vaccine; a method for detection of infection-specific antibodies in a biological specimen; a method for detection of infection-specific antigens in a biological specimen and a method of using therapeutic agents specifically directed against infection-specific peptides, or the genes that code for such peptides, to treat chlamydial infection. The invention also includes the IncB, and IncC proteins of C. psittaci, and nucleotides encoding these proteins, ant the TroA, TroB and p242 proteins of C. trachomatis, and the nucleotides that encode polypeptides.
    Type: Grant
    Filed: October 16, 2000
    Date of Patent: June 8, 2004
    Assignee: State of Oregon Acting by and Through the State Board of Higher Education on Behalf of Oregon State University
    Inventors: Daniel D. Rockey, John P. Bannantine
  • Publication number: 20030175725
    Abstract: The present invention provides nucleic acid molecules unique to M. paratuberculosis. The invention also provides the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules of the invention, and antibodies having specific binding affinity for the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules. The invention further provides for methods of detecting M. paratuberculosis in a sample using nucleic acid molecules, polypeptides, and antibodies of the invention. The invention additionally provides methods of preventing a M. paratuberculosis infection in an animal.
    Type: Application
    Filed: April 30, 2002
    Publication date: September 18, 2003
    Inventors: Vivek Kapur, John P. Bannantine