Abstract: A tethering and restraint safety harness for transporting a large equine or bovine animal in their natural upright position in a trailer is disclosed. Adjustable front and rear girt straps encircle the front and rear parts of the animal immediately behind its front legs and just in front of its hind legs and an adjustable body strap extends around the lateral sides, breast and buttocks of the animal. Front and rear pairs of tether straps connect the harness to eye bolts on an overhead support structure of the trailer to maintain the animal in a natural standing position. The harness substantially reduces the likelihood of the animal tripping or falling and from being, tossed around in the trailer and injuring himself in the event of abrupt stops, sudden swerves, or a collision.