Abstract: The present disclosure provides recombinant adeno-associated virus (AAV) virions with altered capsid protein, where the recombinant AAV (rAAV) virions exhibit greater ability to cross barriers between intravitreal fluid and retinal cells, and thus greater infectivity of a retinal cell compared to wild-type AAV, and where the rAAV virions comprise a heterologous nucleic acid. The present disclosure provides methods of delivering a gene product to a retinal cell in an individual.

Abstract: An electric motor is provided including a stator, a rotor, a motor spindle coupled to the rotor and extending along a center axis, a first end cap formed on a first side of the stator, a second end cap formed on a second side of the stator and secured to the first end cap to form a first compartment around the stator and the rotor, an electro-magnetic brake module disposed on a side of the second end cap opposite the stator and engaged with the motor spindle, and a motor cover mounted on the second end cap to form a second compartment around the electro-magnetic brake module. The first end cap, the second end cap, and the motor cover form a substantially watertight seal around the stator, the rotor, and the position sensor assembly.

Abstract: An electric power apparatus includes a main planar body having a circular opening that supports a brushless direct-current (BLDC) motor. The motor includes a stator, a rotor, a motor spindle extending through the circular opening, a first end cap formed on a first side of the stator and mounted on the main planar body; and a second end cap formed on a second side of the stator and secured to the first end cap to form a substantially watertight seal around the stator and the rotor. A ratio of a maximum power output of the motor when powered by at least one battery pack to a height of the motor as measured from an upper surface of the main planar body to a top surface of the motor is greater than or equal to approximately 34 watts/mm.

Abstract: Methods and apparatus for isolating a heat exchanger core from external ducting coupled to the heat exchanger manifolds. A flexible metal bellows of the externally pressurized type is utilized at each juncture between the inlet and outlet air ducts and the associated integral core manifolds. Similar arrangements are provided at the opposite side of the heat exchanger core where blind ducts are incorporated for balancing of the compression load forces and for access to the manifolds for inspection and maintenance.

Abstract: Air at substantially ambient pressure is cooled in a heat exchanger and introduced into an enclosure for cooling. The air is withdrawn from the enclosure and a portion of the air is expanded through a turbine for additional cooling and passed through the heat exchanger for the removal of heat therefrom. The air is then compressed to substantially ambient pressure and expelled. Additional cooling of the expanded air from the turbine may be obtained by evaporating a fluid therein. The fluid may be water condensed in, and withdrawn from, the heat exchanger.