Patents by Inventor John P. Clayton

John P. Clayton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4534968
    Abstract: A synergistic combination is produced which comprises a synergistically effective amount of clavulanic acid or a pharmaceutically acceptable salt thereof and an antibacterially effective amount of a compound of the formula (II): ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.1 is hydrogen, hydroxyl or acetoxyl, R.sup.2 is methyl and R.sup.3 is CO.R.sup.4 wherein R.sup.4 is phenyl, isobutyl, furyl, thienyl or NHCH.sub.3 or R.sup.2 is joined to R.sup.3 so that NR.sup.2 R.sup.3 is an imidazolin-2-on-1-yl.
    Type: Grant
    Filed: June 26, 1980
    Date of Patent: August 13, 1985
    Assignee: Beecham Group Limited
    Inventor: John P. Clayton
  • Patent number: 4465689
    Abstract: Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
    Type: Grant
    Filed: January 25, 1979
    Date of Patent: August 14, 1984
    Assignee: Beecham Group Limited
    Inventors: Kong Luk, John P. Clayton, Norman H. Rogers
  • Patent number: 4385060
    Abstract: 6.beta.-[2-(2'-methylphenoxycarbonyl)-2-thien-3'-ylacetamido] penicillanic acid of formula (II): ##STR1## and pharmaceutically acceptable salts and in vivo hydrolyzable esters thereof, are active against Gram-positive and Gram-negative bacteria which makes them useful as therapeutic and prophylactic agents against bacterial infections in animals, including man and poultry. A process for the preparation and pharamceutical compositions comprising the penicillin, are also described.
    Type: Grant
    Filed: September 22, 1980
    Date of Patent: May 24, 1983
    Assignee: Beecham Group Limited
    Inventors: John P. Clayton, Martin Cole
  • Patent number: 4318856
    Abstract: Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
    Type: Grant
    Filed: January 14, 1980
    Date of Patent: March 9, 1982
    Assignee: Beecham Group Limited
    Inventors: Kong Luk, John P. Clayton, Norman H. Rogers
  • Patent number: 4289779
    Abstract: Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
    Type: Grant
    Filed: June 11, 1979
    Date of Patent: September 15, 1981
    Assignee: Beecham Group Limited
    Inventors: Kong Luk, John P. Clayton, Norman H. Rogers
  • Patent number: 4283412
    Abstract: Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
    Type: Grant
    Filed: June 11, 1979
    Date of Patent: August 11, 1981
    Assignee: Beecham Group Limited
    Inventors: Kong Luk, John P. Clayton, Norman H. Rogers
  • Patent number: 4283411
    Abstract: Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
    Type: Grant
    Filed: June 11, 1979
    Date of Patent: August 11, 1981
    Assignee: Beecham Group Limited
    Inventors: Kong Luk, John P. Clayton, Norman H. Rogers
  • Patent number: 4267316
    Abstract: Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
    Type: Grant
    Filed: June 14, 1979
    Date of Patent: May 12, 1981
    Assignee: Beecham Group Limited
    Inventors: Kong Luk, John P. Clayton, Norman H. Rogers
  • Patent number: 4260746
    Abstract: 7.alpha.-Methoxy-7.beta.-acylamino cephalosporins are prepared from 7.beta.-acylamino cephalosporins through formation of a ketenimine by the action of an acid halide, formation of an addition reaction adduct of this ketenimine, treatment of the adduct with a methoxide to form a 7.alpha.-methoxy ketenimine and hydrolysis of the latter ketenimine.
    Type: Grant
    Filed: October 15, 1979
    Date of Patent: April 7, 1981
    Assignee: Beecham Group Limited
    Inventors: Andrew W. Taylor, George Burton, John P. Clayton
  • Patent number: 4256762
    Abstract: Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
    Type: Grant
    Filed: May 21, 1979
    Date of Patent: March 17, 1981
    Assignee: Beecham Group Limited
    Inventors: Kong Luk, John P. Clayton, Norman H. Rogers
  • Patent number: 4256879
    Abstract: Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
    Type: Grant
    Filed: June 11, 1979
    Date of Patent: March 17, 1981
    Assignee: Beecham Group Limited
    Inventors: Kong Luk, John P. Clayton, Norman H. Rogers
  • Patent number: 4237161
    Abstract: Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
    Type: Grant
    Filed: August 7, 1978
    Date of Patent: December 2, 1980
    Assignee: Beecham Group Limited
    Inventors: Kong Luk, John P. Clayton, Norman H. Rogers
  • Patent number: 4235784
    Abstract: Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
    Type: Grant
    Filed: January 27, 1978
    Date of Patent: November 25, 1980
    Assignee: Beecham Group Limited
    Inventors: Kong Luk, John P. Clayton, Norman H. Rogers
  • Patent number: 4217448
    Abstract: Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
    Type: Grant
    Filed: June 18, 1979
    Date of Patent: August 12, 1980
    Assignee: Beecham Group Limited
    Inventors: Kong Luk, John P. Clayton, Norman H. Rogers
  • Patent number: 4217447
    Abstract: Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
    Type: Grant
    Filed: June 14, 1979
    Date of Patent: August 12, 1980
    Assignee: Beecham Group Limited
    Inventors: Kong Luk, John P. Clayton, Norman H. Rogers
  • Patent number: 4216223
    Abstract: A thiol acid and esters thereof of formula (II): ##STR1## wherein R is hydrogen, a salt forming ion or a pharmaceutically acceptable ester-forming radical, have antibacterial and antimycoplasmal activity and are therefore useful in the treatment of human and veterinary bacterial and mycoplasmal infections.
    Type: Grant
    Filed: November 22, 1978
    Date of Patent: August 5, 1980
    Assignee: Beecham Group Limited
    Inventors: John P. Clayton, Norman H. Rogers, Steven Coulton
  • Patent number: 4206224
    Abstract: Pseudomonic acid of formula (I): ##STR1## is effective against H. influenzae, N. gonorrhoeae, and Mycoplasma sp organisms and is therefore of value in the treatment of respiratory, venereal and mycoplasma-induced diseases.
    Type: Grant
    Filed: July 14, 1978
    Date of Patent: June 3, 1980
    Assignee: Beecham Group Limited
    Inventor: John P. Clayton
  • Patent number: 4202973
    Abstract: 7.alpha.-Methoxy-7.beta.-acylamino cephalosporins are prepared from 7.beta.-acylamino cephalosporins through formation of a ketenimine by the action of an acid halide, formation of an addition reaction adduct of this ketenimine, treatment of the adduct with a methoxide to form a 7.alpha.-methoxy ketenimine and hydrolysis of the latter ketenimine.
    Type: Grant
    Filed: June 27, 1977
    Date of Patent: May 13, 1980
    Assignee: Beecham Group Limited
    Inventors: Andrew W. Taylor, George Burton, John P. Clayton
  • Patent number: 4196214
    Abstract: Pseudomonic acid of formula (I): ##STR1## is effective against H. influenzae, N. gonorrhoeae, and Mycoplasma sp organisms and is therefore of value in the treatment of respiratory, venereal and mycoplasma-induced diseases.
    Type: Grant
    Filed: October 17, 1977
    Date of Patent: April 1, 1980
    Assignee: Beecham Group Limited
    Inventor: John P. Clayton
  • Patent number: 4185014
    Abstract: A class of ketenimine intermediates are prepared from 6-acrylaminopenicillins having an .alpha.-carboxy substituent in the side-chain, and are useful in the preparation of 6.alpha.-methoxy-.alpha.-carboxy penicillins.
    Type: Grant
    Filed: June 7, 1978
    Date of Patent: January 22, 1980
    Assignee: Beecham Group Limited
    Inventors: Andrew W. Taylor, George Burton, John P. Clayton