Patents by Inventor John P. Cooke

John P. Cooke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6117872
    Abstract: NO precursors are administered at elevated levels in addition to the diet of the individual to enhance exercise performance. Particularly, L-arginine and L-lysine by enhancing endothelial NO production can provide for greater aerobic capacity and improved exercise performance.
    Type: Grant
    Filed: June 23, 1998
    Date of Patent: September 12, 2000
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Andrew J. Maxwell, John P. Cooke
  • Patent number: 6063432
    Abstract: Health bars are provided having high dosages of at least one of the amino acids L-arginine and L-lysine in conjunction with fruit solids and paste, protein and carbohydrates. A number of different fruit sources may be used, grapes finding particular use, and soy being a useful source of proteins. The bars are made by preparing a syrup at an elevated temperature, adding a fruit paste and cooling, followed by the addition of minor ingredients and mixing, the amino acids and a portion of the protein and mixing, followed by the remaining ingredients and formation as a bar.
    Type: Grant
    Filed: May 19, 1998
    Date of Patent: May 16, 2000
    Assignee: Cooke Pharma
    Inventors: Andrew J. Maxwell, John P. Cooke, Thomas Martin Radke
  • Patent number: 5945452
    Abstract: Atherogenesis and restenosis are treated by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. Alternatively, or in combination, other compounds may be administered which provide for short term enhancement of nitric oxide, either directly or by physiological processes. In addition, cells may be genetically engineered to provide a component in the synthetic pathway to nitric oxide, so as to drive the process to enhance nitric oxide concentration, particularly in conjunction with the administration of a nitric oxide precursor.
    Type: Grant
    Filed: February 7, 1997
    Date of Patent: August 31, 1999
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: John P. Cooke, Victor J. Dzau, Gary H. Gibbons
  • Patent number: 5891459
    Abstract: Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds, namely L-arginine, L-lysine, physiologically acceptable salts thereof, and polypeptide precursors thereof, which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. In or in combination, other compounds, such as B.sub.6, folate, B.sub.12, or an antioxidant, which provide for short term enhancement of nitric oxide, either directly or by physiological processes may be employed.
    Type: Grant
    Filed: November 9, 1995
    Date of Patent: April 6, 1999
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: John P. Cooke, Victor J. Dzau, Gary H. Gibbons
  • Patent number: 5861168
    Abstract: Vessels suffering vascular injury from angioplasty are treated with L-arginine intramurally. The incidents associated with restenosis are substantially reduced providing for a reduced incidence of restenosis as a result of the injury.
    Type: Grant
    Filed: December 16, 1996
    Date of Patent: January 19, 1999
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: John P. Cooke, Sverin Schwarzacher, Tai T. Lim, Alan C. Yeung
  • Patent number: 5852058
    Abstract: Vessels suffering vascular injury from angioplasty are treated with L-arginine intramurally. The incidents associated with restenosis are substantially reduced providing for a reduced incidence of restenosis as a result of the injury.
    Type: Grant
    Filed: August 12, 1996
    Date of Patent: December 22, 1998
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: John P. Cooke, Sverin Schwarzacher, Tai T. Lim, Alan C. Yeung
  • Patent number: 5428070
    Abstract: Atherogenesis and restenosis are treated by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide in the host. Alternatively, or in combination, other compounds may be administered which provide for short term enhancement of nitric oxide, either directly or by physiological processes. In addition, cells may be genetically engineered to provide a component in the synthetic pathway to nitric oxide, so as drive the process to enhance nitric oxide concentration, particularly in conjunction with the administration of a nitric oxide precursor.
    Type: Grant
    Filed: June 11, 1993
    Date of Patent: June 27, 1995
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: John P. Cooke, Victor J. Dzau, Gary H. Gibbons
  • Patent number: 4210252
    Abstract: An angleworm storage box comprised of a pair of rigid, integrally formed rectangular frame members which are right angled in cross-section and are connected by a set of corner struts, also right angled in cross-section, and having latch members extending outwardly from their ends which are thrust through apertures defined by elastic materials in the corner portions of the two frames, the frames and struts being molded of rigid plastic material and the portions adjacent the aperture-defining portions being relieved to cause the aperture-defining portions to be more elastic in order to permit the relatively large end portions of the latch elements to pass therethrough and thereafter latch thereagainst to create a rigid, simple and inexpensive box framework. Foot members carried at each corner of the bottom frame are so designed as to nest with the cover member for the box. Simple, unique but highly effective latch means is carried entirely by the cover for the box.
    Type: Grant
    Filed: August 28, 1978
    Date of Patent: July 1, 1980
    Assignee: Inventors Products, Inc.
    Inventors: John P. Cooke, Walter Rohrbach