Abstract: The present invention relates to methods and strategies for extracting nitrosylated and/or nitrated derivatives and analogs from Myrciaria dubia fruit and for synthesizing the same. The ascorbic acid derivatives and analogs have the chemical structure of: where R1 is ?O, —ONO, —ONO2, or —NH2; R2 is —OH, —ONO, —ONO2, or —NH2; R3 is —OH, —ONO, —ONO2. The extraction method comprises freeze-drying the Myrciaria dubia fruit, mixing the freeze-dried powder with a solvent and separating and drying the supernatant. The synthetic method comprises derivatizing an ascorbic acid via nitrosylation and/or nitration in a buffered ascorbic acid solution, reducing zero or more nitro groups to an amine group, and purifying the ascorbic acid analog.

Abstract: The present invention relates to methods and strategies for extracting nitrosylated and/or nitrated derivatives and analogs from Myriciaria dubia fruit and for synthesizing the same. The ascorbic acid derivatives and analogs have the chemical structure of: where R1 is ?O, —ONO, —ONO2, or —NH2; R2 is —OH, —ONO, —ONO2, or —NH2; R3 is —OH, —ONO, —ONO2. The extraction method comprises freeze-drying the Myriciaria dubia fruit, mixing the freeze-dried powder with a solvent and separating and drying the supernatant. The synthetic method comprises derivatizing an ascorbic acid via nitrosylation and/or nitration in a buffered ascorbic acid solution, reducing zero or more nitro groups to an amine group, and purifying the ascorbic acid analog.

Abstract: The present invention relates to methods and strategies for extracting nitrosylated and/or nitrated derivatives and analogs from Myriciaria dubia fruit and for synthesizing the same. The ascorbic acid derivatives and analogs have the chemical structure of: where R1 is ?O, —ONO, —ONO2, or —NH2; R2 is —OH, —ONO, —ONO2, or —NH2; R3 is —OH, —ONO, —ONO2. The extraction method comprises freeze-drying the Myriciaria dubia fruit, mixing the freeze-dried powder with a solvent and separating and drying the supernatant. The synthetic method comprises derivatizing an ascorbic acid via nitrosylation and/or nitration in a buffered ascorbic acid solution, reducing zero or more nitro groups to an amine group, and purifying the ascorbic acid analog.

Abstract: The present invention relates to methods and strategies for extracting nitrosylated and/or nitrated derivatives and analogs from Myriciaria dubia fruit and for synthesizing the same. The ascorbic acid derivatives and analogs have the chemical structure of: where R1 is ?O, —ONO, —ONO2, or —NH2; R2 is —OH, —ONO, —ONO2, or —NH2; R3 is —OH, —ONO, —ONO2. The extraction method comprises freeze-drying the Myriciaria dubia fruit, mixing the freeze-dried powder with a solvent and separating and drying the supernatant. The synthetic method comprises derivatizing an ascorbic acid via nitrosylation and/or nitration in a buffered ascorbic acid solution, reducing zero or more nitro groups to an amine group, and purifying the ascorbic acid analog.

Abstract: Compositions for the treatment of neurodegenerative diseases are disclosed. Methods of treating and monitoring progression of a neurodegenerative disease are disclosed. According to the present invention, a selective CB2 receptor modulator may be administered to a mammal for the treatment of a neurodegenerative disease.

Abstract: Compositions for the treatment of neurodegenerative diseases are disclosed. Methods of treating and monitoring progression of a neurodegenerative disease are disclosed. According to the present invention, a selective CB2 receptor modulator may be administered to a mammal for the treatment of a neurodegenerative disease.

Abstract: The present invention provides a method of treating amyotrophic lateral sclerosis and other neurologic diseases by administering a compound of the formula where R is selected from the group consisting of (C6H4)CO2H, (C6H4)CO2CH3, (C6H4)(3,5-OH)2, (C6H4)CH2OH, (C6H4)OCH3, (C6H4)PO3H, (C6H4)SO3H, (C6H4)(3-NO2-4-OH), (C6H4)NO2, (C6H4)OPO3H, (C6H4)OSO3H, (C6H4)CH2CO2H, (C6H4)NH2, and (C6H4)CONH2. Also provided is a method for preserving donor organs using a solution comprising the instant compounds.

Abstract: The present invention provides a method of treating amyotrophic lateral sclerosis and other neurologic diseases by administering bathocuproine or a related analog. Also provided are pharmaceutical compositions of bathocuproine.